Beta glucan: health benefits in obesity and metabolic syndrome

D El Khoury, C Cuda, B L Luhovyy, G H Anderson, D El Khoury, C Cuda, B L Luhovyy, G H Anderson

Abstract

Despite the lack of international agreement regarding the definition and classification of fiber, there is established evidence on the role of dietary fibers in obesity and metabolic syndrome. Beta glucan (β-glucan) is a soluble fiber readily available from oat and barley grains that has been gaining interest due to its multiple functional and bioactive properties. Its beneficial role in insulin resistance, dyslipidemia, hypertension, and obesity is being continuously documented. The fermentability of β-glucans and their ability to form highly viscous solutions in the human gut may constitute the basis of their health benefits. Consequently, the applicability of β-glucan as a food ingredient is being widely considered with the dual purposes of increasing the fiber content of food products and enhancing their health properties. Therefore, this paper explores the role of β-glucans in the prevention and treatment of characteristics of the metabolic syndrome, their underlying mechanisms of action, and their potential in food applications.

References

    1. World Health Organization: Obesity and overweight: Fact Sheet, .
    1. Fujioka K. Management of obesity as a chronic disease: nonpharmacologic, pharmacologic, and surgical options. Obesity Research. 2002;10(2)
    1. Torpy JM, Lynm C, Glass RM. JAMA patient page. The metabolic syndrome. Journal of the American Medical Association. 2006;295(7):p. 850.
    1. Vrolix R, Mensink RP. Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome. The American Journal of Clinical Nutrition. 2010;92(2):366–374.
    1. Esposito K, Marfella R, Ciotola M, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. Journal of the American Medical Association. 2004;292(12):1440–1446.
    1. McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PWF, Jacques PF. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the framingham offspring cohort. Diabetes Care. 2004;27(2):538–546.
    1. Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F. Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 2005;28(12):2823–2831.
    1. Esmaillzadeh A, Mirmiran P, Azizi F. Whole-grain consumption and the metabolic syndrome: a favorable association in Tehranian adults. European Journal of Clinical Nutrition. 2005;59(3):353–362.
    1. Freire RD, Cardoso MA, Gimeno SGA, Ferreira SRG. Dietary fat is associated with metabolic syndrome in Japanese Brazilians. Diabetes Care. 2005;28(7):1779–1785.
    1. Laaksonen DE, Toppinen LK, Juntunen KS, et al. Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome. American Journal of Clinical Nutrition. 2005;82(6):1218–1227.
    1. Sahyoun NR, Jacques PF, Zhang XL, Juan W, McKeown NM. Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. American Journal of Clinical Nutrition. 2006;83(1):124–131.
    1. Charalampopoulos D, Wang R, Pandiella SS, Webb C. Application of cereals and cereal components in functional foods: a review. International Journal of Food Microbiology. 2002;79(1-2):131–141.
    1. Demirbas A. β-Glucan and mineral nutrient contents of cereals grown in Turkey. Food Chemistry. 2005;90(4):773–777.
    1. Holtekjølen AK, Uhlen AK, Bråthen E, Sahlstrøm S, Knutsen SH. Contents of starch and non-starch polysaccharides in barley varieties of different origin. Food Chemistry. 2006;94(3):348–358.
    1. Stuart IM, Loi L, Fincher GB. Immunological comparison of (1-3,1-4)-beta-glucan endohydrolases in germinating cereals. Journal of Cereal Science. 1987;6(1):45–52.
    1. Bacic A, Fincher GB, Stone BA. Chemistry, Biochemistry, and Biology of (1-3)-[beta]-Glucans and Related Polysaccharides. 1st edition. Amsterdam, The Netherlands: Academic Press; 2009.
    1. Teas J. The dietary intake of Laminaria, a brown seaweed, and breast cancer prevention. Nutrition and Cancer. 1983;4(3):217–222.
    1. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Critical Reviews in Immunology. 1999;19(1):65–96.
    1. Statistics Canada: National supply and disposition of grains in Canada, 2005-2006 to 2010-2011—Barley, .
    1. Statistics Canada: National supply and disposition of grains in Canada, 2005-2006 to 2010-2011—Oats, .
    1. FAOSTAT: food and agricultural commodities production. Countries by commodity, .
    1. Lazaridou A, Biliaderis CG. Molecular aspects of cereal β-glucan functionality: physical properties, technological applications and physiological effects. Journal of Cereal Science. 2007;46(2):101–118.
    1. Wood PJ. Evaluation of oat bran as a soluble fibre source. Characterization of oat β-glucan and its effects on glycaemic response. Carbohydrate Polymers. 1994;25(4):331–336.
    1. Brennan CS, Cleary LJ. The potential use of cereal (1→3, 1→4)-β-d-glucans as functional food ingredients. Journal of Cereal Science. 2005;42(1):1–13.
    1. Phillips GO, Cui SW. An introduction: evolution and finalisation of the regulatory definition of dietary fibre. Food Hydrocolloids. 2011;25(2):139–143.
    1. Champ M, Langkilde AM, Brouns F, Kettlitz B, Le Bail-Collet Y. Advances in dietary fibre characterisation. 2. Consumption, chemistry, physiology and measurement of resistant starch; implications for health and food labelling. Nutrition Research Reviews. 2003;16(2):143–161.
    1. Trowell H. Ischemic heart disease and dietary fiber. American Journal of Clinical Nutrition. 1972;25(9):926–932.
    1. Trowell H, Southgate DA, Wolever TM, Leeds AR, Gassull MA, Jenkins DJ. Letter: dietary fibre redefined. The Lancet. 1976;1(7966):p. 967.
    1. Champ M, Langkilde AM, Brouns F, Kettlitz B, Collet YLB. Advances in dietary fibre characterisation. 1. Definition of dietary fibre, physiological relevance, health benefits and analytical aspects. Nutrition Research Reviews. 2003;16(1):71–82.
    1. Codex Alimentarius Commission: ALINORM 10/33/26, Report of the 31st Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, Düsseldorf, Germany, 2009, .
    1. Jenkins DJA, Wolever TMS, Leeds AR. Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity. British Medical Journal. 1978;1(6124):1392–1394.
    1. Wood PJ, Braaten JT, Scott FW, Riedel KD, Wolynetz MS, Collins MW. Effect of dose and modification of viscous properties of oat gum on plasma glucose and insulin following an oral glucose load. British Journal of Nutrition. 1994;72(5):731–743.
    1. Wong JMW, De Souza R, Kendall CWC, Emam A, Jenkins DJA. Colonic health: fermentation and short chain fatty acids. Journal of Clinical Gastroenterology. 2006;40(3):235–243.
    1. Macfarlane S, Macfarlane GT, Cummings JH. Review article: prebiotics in the gastrointestinal tract. Alimentary Pharmacology and Therapeutics. 2006;24(5):701–714.
    1. Roberfroid MB. Inulin-type fructans: functional food ingredients. Journal of Nutrition. 2007;137(11)
    1. Cummings JH, Roberfroid MB, Andersson H, et al. A new look at dietary carbohydrate: chemistry, physiology and health. European Journal of Clinical Nutrition. 1997;51(7):417–423.
    1. Englyst KN, Englyst HN. Carbohydrate bioavailability. British Journal of Nutrition. 2005;94(1):1–11.
    1. Sullivan DM, Carpenter DE. Methods of Analysis for Nutrition Labeling. Arlington, Va, USA: AOAC International; 1993.
    1. Cho S, DeVries JW, Prosky L. Dietary Fiber Analysis and Applications. Gaithersburg, Md, USA: AOAC International; 1997.
    1. Cummings JH, Stephen AM. Carbohydrate terminology and classification. European Journal of Clinical Nutrition. 2007;61(1):S5–S18.
    1. Englyst KN, Liu S, Englyst HN. Nutritional characterization and measurement of dietary carbohydrates. European Journal of Clinical Nutrition. 2007;61(1):S19–S39.
    1. Cummings JH. Short chain fatty acids in the human colon. Gut. 1981;22(9):763–779.
    1. Cummings JH, Englyst HN, Wiggins HS. The role of carbohydrates in lower gut function. Nutrition Reviews. 1986;44(2):50–54.
    1. Gibson GR, Probert HM, Van Loo J, Rastall RA, Roberfroid MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Reviews. 2004;17(2):259–275.
    1. Douglas LC, Sanders ME. Probiotics and prebiotics in dietetics practice. Journal of the American Dietetic Association. 2008;108(3):510–521.
    1. Lee SC. Dietary fiber analysis for nutrition labelling. Cereal Foods World. 1992;37:765–771.
    1. McCleary BV, Codd R. Measurement of (1-3),(1-4)-beta-D-glucan in barley and oats-a streamlined enzymatic procedure. Journal of the Science of Food and Agriculture. 1991;55(2):303–312.
    1. McCleary BV. An integrated procedure for the measurement of total dietary fibre (including resistant starch), non-digestible oligosaccharides and available carbohydrates. Analytical and Bioanalytical Chemistry. 2007;389(1):291–308.
    1. McCleary BV, DeVries JW, Rader JI, et al. Determination of total dietary fiber (CODEX Definition) by enzymatic-gravimetric method and liquid chromatography: collaborative study. Journal of AOAC International. 2010;93(1):221–233.
    1. Zygmunt LC, Paisley SD. Enzymatic method for determination of (1–>3)(1–>4)-beta-D-glucans in grains and cereals: collaborative study. Journal of AOAC International. 1993;76(5):1069–1082.
    1. Rampitsch C, Ames N, Storsley J, Marien L. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay to quantify soluble β-glucans in oats and barley. Journal of Agricultural and Food Chemistry. 2003;51(20):5882–5887.
    1. Czuchajowska Z, Szczodrak J, Pomeranz Y. Characterization and estimation of barley polysaccharides by near-infrared spectroscopy. 1. Barleys, starches, and beta-deuterium-glucans. Cereal Chemistry. 1992;69(4):413–418.
    1. Jørgensen KG. Quantification of high molecular weight (1→3)(1→4)-β-d-glucan using Calcofluor complex formation and flow injection analysis. I. analytical principle and its standardization. Carlsberg Research Communications. 1988;53(5):277–285.
    1. Brennan CS. Dietary fibre, glycaemic response, and diabetes. Molecular Nutrition and Food Research. 2005;49(6):560–570.
    1. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition. 1999;69(1):30–42.
    1. Önning G, Wallmark A, Persson M, Åkesson B, Elmståhl S, Öste R. Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia. Annals of Nutrition and Metabolism. 1999;43(5):301–309.
    1. Anderson JW, Davidson MH, Blonde L, et al. Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. American Journal of Clinical Nutrition. 2000;71(6):1433–1438.
    1. Slavin JL. Dietary fiber and body weight. Nutrition. 2005;21(3):411–418.
    1. Liu S, Sesso HD, Manson JE, Willett WC, Buring JE. Is intake of breakfast cereals related to total and cause-specific mortality in men? American Journal of Clinical Nutrition. 2003;77(3):594–599.
    1. Jensen MK, Koh-Banerjee P, Hu FB, et al. Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men. American Journal of Clinical Nutrition. 2004;80(6):1492–1499.
    1. Qi L, Van Dam RM, Liu S, Franz M, Mantzoros C, Hu FB. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Diabetes Care. 2006;29(2):207–211.
    1. Artiss JD, Brogan K, Brucal M, Moghaddam M, Jen KLC. The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats. Metabolism. 2006;55(2):195–202.
    1. Galisteo M, Morón R, Rivera L, Romero R, Anguera A, Zarzuelo A. Plantago ovata husks-supplemented diet ameliorates metabolic alterations in obese Zucker rats through activation of AMP-activated protein kinase. Comparative study with other dietary fibers. Clinical Nutrition. 2010;29(2):261–267.
    1. Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology. 2003;144(12):5179–5183.
    1. Steemburgo T, Dall’Alba V, Almeida JC, Zelmanovitz T, Gross JL, de Azevedo MJ. Intake of soluble fibers has a protective role for the presence of metabolic syndrome in patients with type 2 diabetes. European Journal of Clinical Nutrition. 2009;63(1):127–133.
    1. Esposito K, Nappo F, Giugliano F, et al. Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus. American Journal of Clinical Nutrition. 2003;78(6):1135–1140.
    1. Qi L, Rimm E, Liu S, Rifai N, Hu FB. Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men. Diabetes Care. 2005;28(5):1022–1028.
    1. Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB. Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 2005;90(8):4542–4548.
    1. Ripsin CM, Keenan JM, Jacobs DR, et al. Oat products and lipid lowering: a meta-analysis. Journal of the American Medical Association. 1992;267(24):3317–3325.
    1. Hallfrisch J, Behall KM. Physiological responses of men and women to barley and oat extracts (nu-trimX). I. Breath hydrogen, methane, and gastrointestinal symptoms. Cereal Chemistry. 2003;80(1):76–79.
    1. Barsanti L, Passarelli V, Evangelista V, Frassanito AM, Gualtieri P. Chemistry, physico-chemistry and applications linked to biological activities of β-glucans. Natural Product Reports. 2011;28(3):457–466.
    1. Zeković DB, Kwiatkowski S, Vrvić MM, Jakovljević D, Moran CA. Natural and modified (1→3)-β-D-glucans in health promotion and disease alleviation. Critical Reviews in Biotechnology. 2005;25(4):205–230.
    1. McIntosh M, Stone BA, Stanisich VA. Curdlan and other bacterial (1→3)-β-D-glucans. Applied Microbiology and Biotechnology. 2005;68(2):163–173.
    1. Wood PJ. Cereal B-glucans in diet and health. Journal of Cereal Science. 2007;46:230–238.
    1. Volman JJ, Ramakers JD, Plat J. Dietary modulation of immune function by β-glucans. Physiology and Behavior. 2008;94(2):276–284.
    1. Breedveld MW, Miller KJ. Cyclic β-glucans of members of the family Rhizobiaceae. Microbiological Reviews. 1994;58(2):145–161.
    1. Soltanian S, Stuyven E, Cox E, Sorgeloos P, Bossier P. Beta-glucans as immunostimulant in vertebrates and invertebrates. Critical Reviews in Microbiology. 2009;35(2):109–138.
    1. Ooi VEC, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Current Medicinal Chemistry. 2000;7(7):715–729.
    1. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiological Reviews. 2001;81(3):1031–1064.
    1. Kedia G, Vázquez JA, Pandiella SS. Evaluation of the fermentability of oat fractions obtained by debranning using lactic acid bacteria. Journal of Applied Microbiology. 2008;105(4):1227–1237.
    1. Havrlentova M, Petrulakova Z, Burgarova A, et al. Cereal B-glucans and their significance for the preparation of functional foods—a review. Czech Journal of Food Sciences. 2011;29(1):1–14.
    1. Virkki L, Johansson L, Ylinen M, Maunu S, Ekholm P. Structural characterization of water-insoluble nonstarchy polysaccharides of oats and barley. Carbohydrate Polymers. 2005;59(3):357–366.
    1. Bohn JA, BeMiller JN. (1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships. Carbohydrate Polymers. 1995;28(1):3–14.
    1. Fleet GH, Manners DJ. Isolation and composition of an alkali soluble glucan from the cell walls of Saccharomyces cerevisiae. Journal of General Microbiology. 1976;94(1):180–192.
    1. Nelson TE, Lewis BA. Separation and characterization of the soluble and insoluble components of insoluble laminaran. Carbohydrate Research. 1974;33(1):63–74.
    1. Johansson L, Virkki L, Maunu S, Lehto M, Ekholm P, Varo P. Structural characterization of water soluble β-glucan of oat bran. Carbohydrate Polymers. 2000;42(2):143–148.
    1. Ren Y, Ellis PR, Ross-Murphy SB, Wang Q, Wood PJ. Dilute and semi-dilute solution properties of (1→3), (1→4)-β-D-glucan, the endosperm cell wall polysaccharide of oats (Avena sativa L.) Carbohydrate Polymers. 2003;53(4):401–408.
    1. Brown GD, Gordon S. Fungal β-glucans and mammalian immunity. Immunity. 2003;19(3):311–315.
    1. Sonck E, Stuyven E, Goddeeris B, Cox E. The effect of β-glucans on porcine leukocytes. Veterinary Immunology and Immunopathology. 2010;135(3-4):199–207.
    1. Vetvicka V, Vetvickova J. Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality Glucans, blood cholesterol, and macrophage function V. Vetvicka and J. Vetvickova. Journal of Immunotoxicology. 2009;6(1):30–35.
    1. Vetvicka V, Dvorak B, Vetvickova J, et al. Orally administered marine (1→3)-β-d-glucan Phycarine stimulates both humoral and cellular immunity. International Journal of Biological Macromolecules. 2007;40(4):291–298.
    1. Tzianabos AO. Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clinical Microbiology Reviews. 2000;13(4):523–533.
    1. Hetland G, Ohno N, Aaberge IS, Løvik M. Protective effect of β-glucan against systemic Streptococcus pneumoniae infection in mice. FEMS Immunology and Medical Microbiology. 2000;27(2):111–116.
    1. Saegusa S, Totsuka M, Kaminogawa S, Hosoi T. Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid. FEMS Immunology and Medical Microbiology. 2004;41(3):227–235.
    1. Babineau TJ, Hackford A, Kenler A, et al. A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients. Archives of Surgery. 1994;129(11):1204–1210.
    1. Babineau TJ, Marcello P, Swails W, Kenler A, Bistrian B, Forse RA. Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients. Annals of Surgery. 1994;220(5):601–609.
    1. Dellinger EP, Babineau TJ, Bleicher P, et al. Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Archives of Surgery. 1999;134(9):977–983.
    1. Nicolosi R, Bell SJ, Bistrian BR, Greenberg I, Forse RA, Blackburn GL. Plasma lipid changes after supplementation with β-glucan fiber from yeast. American Journal of Clinical Nutrition. 1999;70(2):208–212.
    1. Neyrinck AM, Possemiers S, Verstraete W, De Backer F, Cani PD, Delzenne NM. Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice. Journal of Nutritional Biochemistry. In press.
    1. Wood PJ, Beer MU. Functional oat products. In: Mazza J, editor. Functional Foods, Biochemical and Processing Aspects. Lancester, UK: Technomic Publishing Company; 1998.
    1. Wood PJ, Beer MU, Butler G. Evaluation of role of concentration and molecular weight of oat β-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load. British Journal of Nutrition. 2000;84(1):19–23.
    1. Autio K. Functional aspects of cell wall polysaccharides. In: Eliasson A-C, editor. Carbohydrates in Food. New York, NY, USA: Marcel Dekker; 1996.
    1. Xu H, Song Y, You NC, et al. Prevalence and clustering of metabolic risk factors for type 2 diabetes among Chinese adults in Shanghai, China. BMC Public Health. 2010;10, article 683
    1. Hanai H, Ikuma M, Sato Y, et al. Long-term effects of water-soluble corn bran hemicellulose on glucose tolerance in obese and non-obese patients: improved insulin sensitivity and glucose metabolism in obese subjects. Bioscience, Biotechnology and Biochemistry. 1997;61(8):1358–1361.
    1. Thorsdottir I, Andersson H, Einarsson S. Sugar beet fiber in formula diet reduces postprandial blood glucose, serum insulin and serum hydroxyproline. European Journal of Clinical Nutrition. 1998;52(2):155–156.
    1. Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy BP. Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia. American Journal of Clinical Nutrition. 1999;70(4):466–473.
    1. Sierra M, Garcia JJ, Fernández N, et al. Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects. European Journal of Clinical Nutrition. 2001;55(4):235–243.
    1. Sierra M, García JJ, Fernández N, et al. Therapeutic effects of psyllium in type 2 diabetic patients. European Journal of Clinical Nutrition. 2002;56(9):830–842.
    1. Juntunen KS, Niskanen LK, Liukkonen KH, Poutanen KS, Holst JJ, Mykkänen HM. Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects. American Journal of Clinical Nutrition. 2002;75(2):254–262.
    1. Alminger M, Eklund-Jonsson C. Whole-grain cereal products based on a high-fibre barley or oat genotype lower post-prandial glucose and insulin responses in healthy humans. European Journal of Nutrition. 2008;47(6):294–300.
    1. Kendall CWC, Esfahani A, Hoffman AJ, et al. Effect of novel maize-based dietary fibers on postprandial glycemia and insulinemia. Journal of the American College of Nutrition. 2008;27(6):711–718.
    1. Garcia AL, Otto B, Reich SC, et al. Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. European Journal of Clinical Nutrition. 2007;61(3):334–341.
    1. Song YJ, Sawamura M, Ikeda K, Igawa S, Yamori Y. Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology. 2000;27(1-2):41–45.
    1. Mäkeläinen H, Anttila H, Sihvonen J, et al. The effect of β-glucan on the glycemic and insulin index. European Journal of Clinical Nutrition. 2007;61(6):779–785.
    1. Maki KC, Galant R, Samuel P, et al. Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. European Journal of Clinical Nutrition. 2007;61(6):786–795.
    1. Tappy L, Gügolz E, Würsch P. Effects of breakfast cereals containing various amounts of β-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care. 1996;19(8):831–834.
    1. Tapola N, Karvonen H, Niskanen L, Mikola M, Sarkkinen E. Glycemic responses of oat bran products in type 2 diabetic patients. Nutrition, Metabolism and Cardiovascular Diseases. 2005;15(4):255–261.
    1. Hallfrisch J, Scholfield DJ, Behall KM. Diets containing soluble oat extracts improve glucose and insulin responses of moderately hypercholesterolemic men and women. American Journal of Clinical Nutrition. 1995;61(2):379–384.
    1. Cavallero A, Empilli S, Brighenti F, Stanca AM. High (1→3,1→4)-β-glucan barley fractions in bread making and their effects on human glycemic response. Journal of Cereal Science. 2002;36(1):59–66.
    1. Jenkins AL, Jenkins DJA, Zdravkovic U, Würsch P, Vuksan V. Depression of the glycemic index by high levels of β-glucan fiber in two functional foods tested in type 2 diabetes. European Journal of Clinical Nutrition. 2002;56(7):622–628.
    1. Biörklund M, van Rees A, Mensink RP, Önning G. Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with β-glucans from oats or barley: a randomised dose-controlled trial. European Journal of Clinical Nutrition. 2005;59(11):1272–1281.
    1. Granfeldt Y, Nyberg L, Björck I. Muesli with 4 g oat β-glucans lowers glucose and insulin responses after a bread meal in healthy subjects. European Journal of Clinical Nutrition. 2008;62(5):600–607.
    1. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of muesli with 4 g oat β-glucan on postprandial blood glucose, gastric emptying and satiety in healthy subjects: a randomized crossover trial. Journal of the American College of Nutrition. 2008;27(4):470–475.
    1. Holm J, Koellreutter B, Wursch P. Influence of sterilization, drying and oat bran enrichment of pasta on glucose and insulin responses in healthy subjects and on the rate and extent of in vitro starch digestion. European Journal of Clinical Nutrition. 1992;46(9):629–640.
    1. Björck I, Liljeberg H, Östman E. Low glycaemic-index foods. British Journal of Nutrition. 2000;83(1):S149–S155.
    1. Chandra R, Liddle RA. Cholecystokinin. Current Opinion in Endocrinology, Diabetes and Obesity. 2007;14(1):63–67.
    1. Beck EJ, Tosh SM, Batterham MJ, Tapsell LC, Huang XF. Oat β-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects. Molecular Nutrition and Food Research. 2009;53(10):1343–1351.
    1. Bourdon I, Yokoyama W, Davis P, et al. Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with β-glucan. American Journal of Clinical Nutrition. 1999;69(1):55–63.
    1. Braaten JT, Wood PJ, Scott FW, Riedel KD, Poste LM, Collins MW. Oat gum lowers glucose and insulin after an oral glucose load. American Journal of Clinical Nutrition. 1991;53(6):1425–1430.
    1. Marciani L, Gowland PA, Spiller RC, et al. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. American Journal of Physiology. 2001;280(6):G1227–G1233.
    1. Darwiche G, Björgell O, Almér LO. The addition of locust bean gum but not water delayed the gastric emptying rate of a nutrient semisolid meal in healthy subjects. BMC Gastroenterology. 2003;3, article 12
    1. Edwards CA, Johnson IT, Read NW. Do viscous polysaccharides slow absorption by inhibiting diffusion or convection? European Journal of Clinical Nutrition. 1988;42(4):307–312.
    1. Schneeman BO, Gallaher D. Effects of dietary fiber on digestive enzyme activity and bile acids in the small intestine. Proceedings of the Society for Experimental Biology and Medicine. 1985;180(3):409–414.
    1. Eastwood MA, Morris ER. Physical properties of dietary fiber that influence physiological function: a model for polymers along the gastrointestinal tract. American Journal of Clinical Nutrition. 1992;55(2):436–442.
    1. Wood PJ, Weisz J, Blackwell BA. Structural studies of (1-3)(1-4)-B-D-glucans by 13C-NMR and by rapid analysis of cellulose-like regions using high-performance anion-exchange chromatography of oligosaccharides released by lichenase. Cereal Chemistry. 1994;71:301–307.
    1. Nazare JA, Normand S, Triantafyllou AO, De La Perrière AB, Desage M, Laville M. Modulation of the postprandial phase by β-glucan in overweight subjects: effects on glucose and insulin kinetics. Molecular Nutrition and Food Research. 2009;53(3):361–369.
    1. Battilana P, Ornstein K, Minehira K, et al. Mechanisms of action of β-glucan in postprandial glucose metabolism in healthy men. European Journal of Clinical Nutrition. 2001;55(5):327–333.
    1. Cummings JH, Englyst HN. Fermentation in the human large intestine and the available substrates. American Journal of Clinical Nutrition. 1987;45(5):1243–1255.
    1. Park KS, Ciaraldi TP, Lindgren K, et al. Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-γ . Journal of Clinical Endocrinology and Metabolism. 1998;83(8):2830–2835.
    1. Solà R, Bruckert E, Valls RM, et al. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: a randomised trial. Atherosclerosis. 2010;211(2):630–637.
    1. Abumweis SS, Jew S, Ames NP. beta-glucan from barley and its lipid-lowering capacity: a meta-analysis of randomized, controlled trials. European Journal of Clinical Nutrition. 2010;64(12):1472–1480.
    1. Chandalia M, Garg A, Lutjohann D, Von Bergmann K, Grundy SM, Brinkley LJ. Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. The New England Journal of Medicine. 2000;342(19):1392–1398.
    1. Solà R, Godàs G, Ribalta J, et al. Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease. American Journal of Clinical Nutrition. 2007;85(4):1157–1163.
    1. Talati R, Baker WL, Pabilonia MS, White CM, Coleman CI. The effects of Barley-derived soluble fiber on serum lipids. Annals of Family Medicine. 2009;7(2):157–163.
    1. Asp NG, Mattsson B, Onning G. Variation in dietary fibre, β-glucan, starch, protein, fat and hull content of oats grown in Sweden 1987-1989. European Journal of Clinical Nutrition. 1992;46(1):31–37.
    1. Luhaloo M, Mårtensson A-C, Andersson R, Åman P. Compositional analysis and viscosity measurements of commercial oat brans. Journal of the Science of Food and Agriculture. 1998;76:142–148.
    1. Drozdowski LA, Reimer RA, Temelli F, Bell RC, Vasanthan T, Thomson ABR. β-Glucan extracts inhibit the in vitro intestinal uptake of long-chain fatty acids and cholesterol and down-regulate genes involved in lipogenesis and lipid transport in rats. Journal of Nutritional Biochemistry. 2010;21(8):695–701.
    1. Delaney B, Nicolosi RJ, Wilson TA, et al. β-Glucan fractions from barley and oats are similarly antiatherogenic in hypercholesterolemic Syrian golden hamsters. Journal of Nutrition. 2003;133(2):468–475.
    1. Shimizu C, Kihara M, Aoe S, et al. Effect of high β-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men—a randomized, double-blinded, placebo-controlled trial. Plant Foods for Human Nutrition. 2008;63(1):21–25.
    1. Behall KM, Scholfield DJ, Hallfrisch J. Lipids significantly reduced by diets containing Barley in moderately hypercholesterolemic men. Journal of the American College of Nutrition. 2004;23(1):55–62.
    1. Behall KM, Scholfield DJ, Hallfrisch J. Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. American Journal of Clinical Nutrition. 2004;80(5):1185–1193.
    1. Keogh GF, Cooper GJS, Mulvey TB, et al. Randomized controlled crossover study of the effect of a highly β-glucan-enriched barley on cardiovascular disease risk factors in mildly hypercholesterolemic men. American Journal of Clinical Nutrition. 2003;78(4):711–718.
    1. Health Canada: Oat Products adn Blood Cholesterol Lowering, Summary of Assessment of a Health Claim about Oat Products and Blood Cholesterol Lowering, .
    1. Davidson MH, Dugan LD, Burns JH, Bova J, Story K, Drennan KB. The hypocholesterolemic effects of β-glucan in oatmeal and oat bran. A dose-controlled study. Journal of the American Medical Association. 1991;265(14):1833–1839.
    1. Reyna-Villasmil N, Bermúdez-Pirela V, Mengual-Moreno E, et al. Oat-derived β-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. American Journal of Therapeutics. 2007;14(2):203–212.
    1. Queenan KM, Stewart ML, Smith KN, Thomas W, Fulcher RG, Slavin JL. Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutrition Journal. 2007;6, article 6
    1. Biörklund M, Holm J. Serum lipids and postprandial glucose and insulin levels in hyperlipidemic subjects after consumption of an oat β-glucan-containing ready meal. Annals of Nutrition and Metabolism. 2008;52(2):83–90.
    1. Torronen R, Kansanen L, Uusitupa M, et al. Effects of an oat bran concentrate on serum lipids in free-living men with mild to moderate hypercholesterolaemia. European Journal of Clinical Nutrition. 1992;46(9):621–627.
    1. Whyte JL, McArthur R, Topping D, Nestel P. Oat bran lowers plasma cholesterol levels in mildly hypercholesterolemic men. Journal of the American Dietetic Association. 1992;92(4):446–449.
    1. Poulter N, Choon Lan Chang, Cuff A, Poulter C, Sever P, Thom S. Lipid profiles after the daily consumption of an oat-based cereal: a controlled crossover trial. American Journal of Clinical Nutrition. 1994;59(1):66–69.
    1. Lovegrove JA, Clohessy A, Milon H, Williams CM. Modest doses of β-glucan do not reduce concentrations of potentially atherogenic lipoproteins. American Journal of Clinical Nutrition. 2000;72(1):49–55.
    1. Kerckhoffs DAJM, Hornstra G, Mensink RP. Cholesterol-lowering effect of β-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when β-glucan is incorporated into bread and cookies. American Journal of Clinical Nutrition. 2003;78(2):221–227.
    1. Pomeroy S, Tupper R, Cehun-Aders M, Nestel P. Oat beta-glucan lowers total and LDL-cholesterol. Australian Journal of Nutrition and Dietetics. 2001;58:51–55.
    1. de Groot AP, Luyken R, Pikaar NA. Cholesterol-lowering effect of rolled oats. The Lancet. 1963;282(7302):303–304.
    1. Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men. American Journal of Clinical Nutrition. 1990;52(4):661–666.
    1. Leadbetter J, Ball MJ, Mann JI. Effects of increasing quantities of oat bran in hypercholesterolemic people. American Journal of Clinical Nutrition. 1991;54(5):841–845.
    1. Bremer JM, Scott RS, Lintott CJ. Oat bran and cholesterol reduction: evidence against specific effect. Australian and New Zealand Journal of Medicine. 1991;21(4):422–426.
    1. Trogh I, Courtin CM, Andersson AAM, Åman P, Sørensen JF, Delcour JA. The combined use of hull-less barley flour and xylanase as a strategy for wheat/hull-less barley flour breads with increased arabinoxylan and (1→3,1→4)-β-D-glucan levels. Journal of Cereal Science. 2004;40(3):257–267.
    1. Burkus Z, Temelli F. Effect of extraction conditions on yield, composition, and viscosity stability of barley β-glucan gum. Cereal Chemistry. 1998;75(6):805–809.
    1. Wood PJ, Weisz J, Mahn W. Molecular characterization of cereal β-glucans. II. Size-exclusion chromatography for comparison of molecular weight. Cereal Chemistry. 1991;68:530–536.
    1. Beer MU, Wood PJ, Weisz J. Molecular weight distribution and (1→3)(1→4)-β-D-glucan content of consecutive extracts of various oat and barley cultivars. Cereal Chemistry. 1997;74(4):476–480.
    1. Åman P, Rimsten L, Andersson R. Molecular weight distribution of β-glucan in oat-based foods. Cereal Chemistry. 2004;81(3):356–360.
    1. Lambo AM, Öste R, Nyman MEGL. Dietary fibre in fermented oat and barley β-glucan rich concentrates. Food Chemistry. 2005;89(2):283–293.
    1. Theuwissen E, Mensink RP. Water-soluble dietary fibers and cardiovascular disease. Physiology and Behavior. 2008;94(2):285–292.
    1. Goel V, Cheema SK, Agellon LB, Ooraikul B, Basu TK. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7α-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. British Journal of Nutrition. 1999;81(1):65–71.
    1. Zhang JX, Hallmans G, Andersson H, et al. Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies. American Journal of Clinical Nutrition. 1992;56(1):99–105.
    1. Dongowski G, Huth M, Gebhardt E. Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets. British Journal of Nutrition. 2003;90(5):895–906.
    1. Mälkki Y, Autio K, Hanninen O. Oat bran concentrates: physical properties of β-glucan and hypocholesterolemic effects in rats. Cereal Chemistry. 1992;69:647–653.
    1. Lia A, Hallmans G, Sandberg AS, Sundberg B, Aman P, Andersson H. Oat β-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. American Journal of Clinical Nutrition. 1995;62(6):1245–1251.
    1. Marlett JA, Hosig KB, Vollendorf NW, Shinnick FL, Haack VS, Story JA. Mechanism of serum cholesterol reduction by oat bran. Hepatology. 1994;20(6):1450–1457.
    1. Hillman LC, Peters SG, Fisher CA, Pomare EW. Effects of the fibre components pectin, cellulose, and lignin on bile salt metabolism and biliary lipid composition in man. Gut. 1986;27(1):29–36.
    1. Lin Y, Vonk RJ, Slooff JH, Kuipers F, Smit MJ. Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. British Journal of Nutrition. 1995;74(2):197–207.
    1. Wolever TMS, Fernandes J, Rao AV. Serum acetate:propionate ratio is related to serum cholesterol in men but not women. Journal of Nutrition. 1996;126(11):2790–2797.
    1. Wolever TMS, Spadafora P, Eshuis H. Interaction between colonic acetate and propionate in humans. American Journal of Clinical Nutrition. 1991;53(3):681–687.
    1. Wolever TMS, Spadafora PJ, Cunnane SC, Pencharz PB. Propionate inhibits incorporation of colonic [1,2-13C]acetate into plasma lipids in humans. American Journal of Clinical Nutrition. 1995;61(6):1241–1247.
    1. Wright RS, Anderson JW, Bridges SR. Propionate inhibits hepatocyte lipid synthesis. Proceedings of the Society for Experimental Biology and Medicine. 1990;195(1):26–29.
    1. Bridges SR, Anderson JW, Deakins DA, Dillon DW, Wood CL. Oat bran increases serum acetate of hypercholesterolemic men. American Journal of Clinical Nutrition. 1992;56(2):455–459.
    1. Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. Journal of Nutrition. 1989;119(8):1100–1106.
    1. Liljeberg H, Björck I. Effects of a low-glycaemic index spaghetti meal on glucose tolerance and lipaemia at a subsequent meal in healthy subjects. European Journal of Clinical Nutrition. 2000;54(1):24–28.
    1. Parks EJ. Dietary carbohydrate’s effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations. British Journal of Nutrition. 2002;87(2):S247–S253.
    1. Kok N, Roberfroid M, Delzenne N. Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism. 1996;45(12):1547–1550.
    1. Kok BYN, Roberfroid M, Robert A, Delzenne N. Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition. 1996;76(6):881–890.
    1. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. Journal of the American Medical Association. 2003;289(19):2560–2572.
    1. Whelton SP, Hyre AD, Pedersen B, Yi Y, Whelton PK, He J. Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. Journal of Hypertension. 2005;23(3):475–481.
    1. Jenkins DJA, Kendall CWC, Vuksan V, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. American Journal of Clinical Nutrition. 2002;75(5):834–839.
    1. Keenan JM, Pins JJ, Frazel C, Moran A, Turnquist L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. The Journal of Family Practice. 2002;51(4):p. 369.
    1. He J, Streiffer RH, Muntner P, Krousel-Wood MA, Whelton PK. Effect of dietary fiber intake on blood pressure: a randomized, double-blind, placebo-controlled trial. Journal of Hypertension. 2004;22(1):73–80.
    1. Ferrannini E, Buzzigoli G, Bonadonna R. Insulin resistance in essential hypertension. The New England Journal of Medicine. 1987;317(6):350–357.
    1. Ferri C, Bellini C, Desideri G, et al. Relationship between insulin resistance and nonmodulating hypertension: linkage of metabolic abnormalities and cardiovascular risk. Diabetes. 1999;48(8):1623–1630.
    1. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. The New England Journal of Medicine. 1995;332(8):488–493.
    1. Vogel RA, Corretti MC, Plotnick GD. Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. American Journal of Cardiology. 1996;77(1):37–40.
    1. Crago MS, West SD, Hoeprich KD, Michaelis KJ, McKenzie JE. Effects of hyperlipidemia on blood pressure and coronary blood flow in swine. The FASEB Journal. 1998;12(4):p. A238.
    1. Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42(5):878–884.
    1. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and weight regulation. Nutrition Reviews. 2001;59(5):129–139.
    1. Rigaud D, Ryttig KR, Angel LA, Apfelbaum M. Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial. International Journal of Obesity. 1990;14(9):763–769.
    1. Birketvedt GS, Aaseth J, Florholmen JR, Ryttig K. Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects. Acta Medica. 2000;43(4):129–132.
    1. Pittler MH, Ernst E. Guar gum for body weight reduction: meta-analysis of randomized trials. American Journal of Medicine. 2001;110(9):724–730.
    1. Mueller-Cunningham WM, Quintana R, Kasim-Karakas SE. An ad libitum, very low-fat diet results in weight loss and changes in nutrient intakes in postmenopausal women. Journal of the American Dietetic Association. 2003;103(12):1600–1606.
    1. Hays NP, Starling RD, Liu X, et al. Effects of an Ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial. Archives of Internal Medicine. 2004;164(2):210–217.
    1. Birketvedt GS, Shimshi M, Thom E, Florholmen J. Experiences with three different fiber supplements in weight reduction. Medical Science Monitor. 2005;11(1):PI5–PI8.
    1. Dikeman CL, Fahey GC. Viscosity as related to dietary fiber: a review. Critical Reviews in Food Science and Nutrition. 2006;46(8):649–663.
    1. Kovacs EMR, Westerterp-Plantenga MS, Saris WHM, Goossens I, Geurten P, Brouns F. The effect of addition of modified guar gum to a low-energy semisolid meal on appetite and body weight loss. International Journal of Obesity. 2001;25(3):307–315.
    1. Raben A, Andersen K, Karberg MA, Holst JJ, Astrup A. Acetylation of or β-cyclodextrin addition to potato starch: beneficial effect on glucose metabolism and appetite sensations. American Journal of Clinical Nutrition. 1997;66(2):304–314.
    1. Buckley JD, Thorp AA, Murphy KJ, Howe PRC. Dose-dependent inhibition of the post-prandial glycaemic response to a standard carbohydrate meal following incorporation of alpha-cyclodextrin. Annals of Nutrition and Metabolism. 2006;50(2):108–114.
    1. Pasman W, Wils D, Saniez MH, Kardinaal A. Long-term gastrointestinal tolerance of NUTRIOSE FB in healthy men. European Journal of Clinical Nutrition. 2006;60(8):1024–1034.
    1. Chow J, Choe YS, Noss MJ, et al. Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes. Diabetes Research and Clinical Practice. 2007;76(3):335–340.
    1. Schroeder N, Gallaher DD, Arndt EA, Marquart L. Influence of whole grain barley, whole grain wheat, and refined rice-based foods on short-term satiety and energy intake. Appetite. 2009;53(3):363–369.
    1. Granfeldt Y, Liljeberg H, Drews A, Newman R, Bjorck I. Glucose and insulin responses to barley products: influence of food structure and amylose-amylopectin ratio. American Journal of Clinical Nutrition. 1994;59(5):1075–1082.
    1. Liljeberg HGM, Åkerberg AKE, Björck IME. Effect of the glycemic index and content of indigestible carbohydrates of cereal-based breakfast meals on glucose tolerance at lunch in healthy subjects. American Journal of Clinical Nutrition. 1999;69(4):647–655.
    1. Kaplan RJ, Greenwood CE. Influence of dietary carbohydrates and glycaemic response on subjective appetite and food intake in healthy elderly persons. International Journal of Food Sciences and Nutrition. 2002;53(4):305–316.
    1. Rytter E, Erlanson-Albertsson C, Lindahl L, et al. Changes in plasma insulin, enterostatin, and lipoprotein levels during an energy-restricted dietary regimen including a new oat-based liquid food. Annals of Nutrition and Metabolism. 1996;40(4):212–220.
    1. Lyly M, Liukkonen KH, Salmenkallio-Marttila M, Karhunen L, Poutanen K, Lähteenmäki L. Fibre in beverages can enhance perceived satiety. European Journal of Nutrition. 2009;48(4):251–258.
    1. Vitaglione P, Lumaga RB, Stanzione A, Scalfi L, Fogliano V. β-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term. Appetite. 2009;53(3):338–344.
    1. Saltzman E, Moriguti JC, Das SK, et al. Effects of a cereal rich in soluble fiber on body composition and dietary compliance during consumption of a hypocaloric diet. Journal of the American College of Nutrition. 2001;20(1):50–57.
    1. Kim H, Behall KM, Vinyard B, Conway JM. Short-term satiety and glycemic response after consumption of whole grains with various amounts of β-glucan. Cereal Foods World. 2006;51(1):29–33.
    1. Peters HPF, Boers HM, Haddeman E, Melnikov SM, Qvyjt F. No effect of added β-glucan or of fructooligosaccharide on appetite or energy intake. American Journal of Clinical Nutrition. 2009;89(1):58–63.
    1. Lyly M, Ohls N, Lähteenmäki L, et al. The effect of fibre amount, energy level and viscosity of beverages containing oat fibre supplement on perceived satiety. Food and Nutrition Research. 2010;54(1):1–8.
    1. Vitaglione P, Lumaga RB, Montagnese C, Messia MC, Marconi E, Scalfi L. Satiating effect of a barley beta-glucan-enriched snack. Journal of the American College of Nutrition. 2010;29(2):113–121.
    1. Burkus Z, Temelli F. Determination of the molecular weight of barley β-glucan using intrinsic viscosity measurements. Carbohydrate Polymers. 2003;54(1):51–57.
    1. Lazaridou A, Biliaderis CG, Izydorczyk MS. Function Food Carbohydrates. Boca Raton, Fla, USA: CRC Press; 2007. Cereal beta-glucans: structures, physical properties, and physiological functions.
    1. Beer MU, Wood PJ, Weisz J, Fillion N. Effect of cooking and storage on the amount and molecular weight of (1→3)(1→4)-β-D-glucan extracted from oat products by an in vitro digestion system. Cereal Chemistry. 1997;74(6):705–709.
    1. Kirkmeyer SV, Mattes RD. Effects of food attributes on hunger and food intake. International Journal of Obesity. 2000;24(9):1167–1175.
    1. Pick ME, Hawrysh ZJ, Gee MI, Toth E, Garg ML, Hardin RT. Oat bran concentrate bread products improve long-term control of diabetes: a pilot study. Journal of the American Dietetic Association. 1996;96(12):1254–1261.
    1. Beck EJ, Tapsell LC, Batterham MJ, Tosh SM, Huang XF. Oat β-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women. British Journal of Nutrition. 2010;103(8):1212–1222.
    1. Burton-Freeman B. Dietary fiber and energy regulation. Journal of Nutrition. 2000;130(2, supplement):272S–275S.
    1. Mattes RD, Rothacker D. Beverage viscosity is inversely related to postprandial hunger in humans. Physiology and Behavior. 2001;74(4-5):551–557.
    1. Zijlstra N, Mars M, De Wijk RA, Westerterp-Plantenga MS, De Graaf C. The effect of viscosity on ad libitum food intake. International Journal of Obesity. 2008;32(4):676–683.
    1. Rigaud D, Paycha F, Meulemans A, Merrouche M, Mignon M. Effect of psyllium on gastric emptying, hunger feeling and food intake in normal volunteers: a double blind study. European Journal of Clinical Nutrition. 1998;52(4):239–245.
    1. Isaksson G, Lundquist I, Ihse I. Effect of dietary fiber on pancreatic enyzme in vitro. Gastroenterology. 1982;82(5):918–924.
    1. Juvonen KR, Purhonen AK, Salmenkallio-Marttila M, et al. Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans. Journal of Nutrition. 2009;139(3):461–466.
    1. Ellis PR, Dawoud FM, Morris ER. Blood glucose, plasma insulin and sensory responses to guar-containing wheat breads: effects of molecular weight and particle size of guar gum. British Journal of Nutrition. 1991;66(3):363–379.
    1. De Graaf C, De Jong LS, Lambers AC. Palatability affects satiation but not satiety. Physiology and Behavior. 1999;66(4):681–688.
    1. Berg C, Jonsson I, Conner M, Lissner L. Perceptions and reasons for choice of fat-and fibre-containing foods by Swedish schoolchildren. Appetite. 2003;40(1):61–67.
    1. Holt SHA, Brand Miller JC, Petocz P, Farmakalidis E. A satiety index of common foods. European Journal of Clinical Nutrition. 1995;49(9):675–690.
    1. Mårtensson O, Biörklund M, Lambo AM, et al. Fermented, ropy, oat-based products reduce cholesterol levels and stimulate the bifidobacteria flora in humans. Nutrition Research. 2005;25(5):429–442.
    1. Holt S, Brand J, Soveny C, Hansky J. Relationship of satiety to postprandial glycaemic, insulin and cholecystokinin responses. Appetite. 1992;18(2):129–141.
    1. Holt SHA, Miller JB. Increased insulin responses to ingested foods are associated with lessened satiety. Appetite. 1995;24(1):43–54.
    1. Anderson GH, Catherine NLA, Woodend DM, Wolever TMS. Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men. American Journal of Clinical Nutrition. 2002;76(5):1023–1030.
    1. Stewart SL, Black RM, Wolever TMS, Anderson GH. The relationship between the glycaemic response to breakfast cereals and subjective appetite and food intake. Nutrition Research. 1997;17(8):1249–1260.
    1. Anderson GH, Woodend D. Effect of glycemic carbohydrates on short-term satiety and food intake. Nutrition Reviews. 2003;61(5):S17–S26.
    1. Cummings JH, Pomare EW, Branch WJ, Naylor CPE, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 1987;28(10):1221–1227.
    1. Roediger WEW. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980;21(9):793–798.
    1. Hong YH, Nishimura Y, Hishikawa D, et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology. 2005;146(12):5092–5099.
    1. Sleeth ML, Thompson EL, Ford HE, Zac-Varghese SEK, Frost G. Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. Nutrition Research Reviews. 2010;23(1):135–145.
    1. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. Review article: the role of butyrate on colonic function. Alimentary Pharmacology and Therapeutics. 2008;27(2):104–119.
    1. Kendall PE, McLeay LM. Excitatory effects of volatile fatty acids on the in vitro motility of the rumen of sheep. Research in Veterinary Science. 1996;61(1):1–6.
    1. Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews. 1990;70(2):567–590.
    1. Dass NB, John AK, Bassil AK, et al. The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterology and Motility. 2007;19(1):66–74.
    1. Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki SI, Kuwahara A. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. Journal of Physiology and Pharmacology. 2008;59(2):251–262.
    1. Cherbut C. Effects of short-chain fatty acids on gastrointestinal motility. In: Cummings JH, Rombeau JL, Sakata T, editors. Physiological and Clinical Aspects of Short-Chain Fatty Acids. Cambridge, UK: Cambridge University Press; 1995.
    1. Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annual Review of Medicine. 2009;60:355–366.
    1. Kim DY, Camilleri M. Serotonin: a mediator of the brain-gut connection. American Journal of Gastroenterology. 2000;95(10):2704–2709.
    1. Zhu JX, Wu XY, Owyang C, Li Y. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. Journal of Physiology. 2001;530(3):431–442.
    1. Fukumoto S, Tatewaki M, Yamada T, et al. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. American Journal of Physiology. 2003;284(5):R1269–R1276.
    1. Dumoulin V, Moro F, Barcelo A, Dakka T, Cuber JC. Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum. Endocrinology. 1998;139(9):3780–3786.
    1. Tatemoto K, Mutt V. Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature. 1980;285(5764):417–418.
    1. Eberlein GA, Eysselein VE, Schaeffer M, et al. A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36) Peptides. 1989;10(4):797–803.
    1. Adrian TE, Ferri GL, Bacarese-Hamilton AJ. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology. 1985;89(5):1070–1077.
    1. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY3-36 physiologically inhibits food intake. Nature. 2002;418(6898):650–654.
    1. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. The New England Journal of Medicine. 2003;349(10):941–948.
    1. Karhunen LJ, Juvonen KR, Flander SM, et al. A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. Journal of Nutrition. 2010;140(4):737–744.
    1. Reimer RA, Pelletier X, Carabin IG, et al. Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults. European Journal of Clinical Nutrition. 2010;64(10):1186–1191.
    1. Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. American Journal of Clinical Nutrition. 2009;89(6):1751–1759.
    1. Beck EJ, Tapsell LC, Batterham MJ, Tosh SM, Huang XF. Increases in peptide Y-Y levels following oat beta-glucan ingestion are dose-dependent in overweight adults. Nutrition Research. 2009;29(10):705–709.
    1. Longo WE, Ballantyne GH, Savoca PE, Adrian TE, Bilchik AJ, Modlin IM. Short-chain fatty acid release of peptide YY in the isolated rabbit distal colon. Scandinavian Journal of Gastroenterology. 1991;26(4):442–448.
    1. Cherbut C, Ferrier L, Rozé C, et al. Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. American Journal of Physiology. 1998;275(6):G1415–G1422.
    1. Karaki SI, Mitsui R, Hayashi H, et al. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell and Tissue Research. 2006;324(3):353–360.
    1. Holst JJ. The physiology of glucagon-like peptide 1. Physiological Reviews. 2007;87(4):1409–1439.
    1. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V. Glucagon-like peptide-1(7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. Journal of Endocrinology. 1993;138(1):159–166.
    1. Turton MD, O’Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 1996;379(6560):69–72.
    1. Davis HR, Mnllins DE, Pines JM, et al. Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats. Obesity Research. 1998;6(2):147–156.
    1. Verdich C, Flint A, Gutzwiller JP, et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on Ad Libitum energy intake in humans. Journal of Clinical Endocrinology and Metabolism. 2001;86(9):4382–4389.
    1. Cani PD, Hoste S, Guiot Y, Delzenne NM. Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. British Journal of Nutrition. 2007;98(1):32–37.
    1. Adam TCM, Westerterp-Plantenga MS. Nutrient-stimulated GLP-1 release in normal-weight men and women. Hormone and Metabolic Research. 2005;37(2):111–117.
    1. Raben A, Tagliabue A, Christensen NJ, Madsen J, Holst JJ, Astrup A. Resistant starch: the effect on postprandial glycemia, hormonal response, and satiety. American Journal of Clinical Nutrition. 1994;60(4):544–551.
    1. Frost GS, Brynes AE, Dhillo WS, Bloom SR, McBurney MI. The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. European Journal of Clinical Nutrition. 2003;57(2):293–298.
    1. Massimino SP, McBurney MI, Field CJ, et al. Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. Journal of Nutrition. 1998;128(10):1786–1793.
    1. Cani PD, Dewever C, Delzenne NM. Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. British Journal of Nutrition. 2004;92(3):521–526.
    1. Delzenne NM, Cani PD, Daubioul C, Neyrinck AM. Impact of inulin and oligofructose on gastrointestinal peptides. British Journal of Nutrition. 2005;93:S157–S161.
    1. Keenan MJ, Zhou J, McCutcheon KL, et al. Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat. Obesity. 2006;14(9):1523–1534.
    1. Delmée E, Cani PD, Gual G, et al. Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice. Life Sciences. 2006;79(10):1007–1013.
    1. Zhou J, Hegsted M, McCutcheon KL, et al. Peptide YY and proglucagon mRNA expression patterns and regulation in the gut. Obesity. 2006;14(4):683–689.
    1. Zhou J, Martin RJ, Tulley RT, et al. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. American Journal of Physiology. 2008;295(5):E1160–E1166.
    1. Piche T, Des Varannes SB, Sacher-Huvelin S, Holst JJ, Cuber JC, Galmiche JP. Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology. 2003;124(4):894–902.
    1. Greenway F, O’Neil CE, Stewart L, Rood J, Keenan M, Martin R. Fourteen weeks of treatment with Viscofiber increased fasting levels of glucagon-like peptide-1 and peptide-YY. Journal of Medicinal Food. 2007;10(4):720–724.
    1. Cani PD, Lecourt E, Dewulf EM, et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. American Journal of Clinical Nutrition. 2009;90(5):1236–1243.
    1. Gee JM, Johnson IT. Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans. Nutrition. 2005;21(10):1036–1043.
    1. Frost G, Brynes A, Leeds A. Effect of large bowel fermentation on insulin, glucose, free fatty acids, and glucagon-like peptide 1 (7-36) amide in patients with coronary heart disease. Nutrition. 1999;15(3):183–188.
    1. May T, Mackie RI, Fahey GC, Cremin JC, Garleb KA. Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by clostridium difficile. Scandinavian Journal of Gastroenterology. 1994;29(10):916–922.
    1. Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats. Journal of Comparative and Physiological Psychology. 1973;84(3):488–495.
    1. Liddle RA, Goldfine ID, Rosen MS. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. Journal of Clinical Investigation. 1985;75(4):1144–1152.
    1. Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. American Journal of Clinical Nutrition. 1981;34(2):154–160.
    1. Burton-Freeman B, Davis PA, Schneeman BO. Plasma cholecystokinin is associated with subjective measures of satiety in women. American Journal of Clinical Nutrition. 2002;76(3):659–667.
    1. Heini AF, Lara-Castro C, Schneider H, Kirk KA, Considine RV, Weinsier RL. Effect of hydrolyzed guar fiber on fasting and postprandial satiety and satiety hormones: a double-blind, placebo-controlled trial during controlled weight loss. International Journal of Obesity. 1998;22(9):906–909.
    1. Bourdon I, Olson B, Backus R, Richter BD, Davis PA, Schneeman BO. Beans, as a source of dietary fiber, increase cholecystokinin and apolipoprotein B48 response to test meals in men. Journal of Nutrition. 2001;131(5):1485–1490.
    1. Sileikiene V, Mosenthin R, Bauer E, et al. Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs. Pancreas. 2008;37(2):196–202.
    1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656–660.
    1. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8):1714–1719.
    1. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407(6806):908–913.
    1. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature. 2001;409(6817):194–198.
    1. Nedvídková J, Krykorková I, Barták V, et al. Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism. 2003;88(4):1678–1682.
    1. Erdmann J, Lippl F, Schusdziarra V. Differential effect of protein and fat on plasma ghrelin levels in man. Regulatory Peptides. 2003;116(1–3):101–107.
    1. Karhunen LJ, Flander S, Liukkonen KH, et al. Fiber effectively inhibits postprandial decrease in plasma ghrelin concentration. Abstract Obesity Reviews. 2005;6:p. 59.
    1. Möhlig M, Koebnick C, Weickert MO, et al. Arabinoxylan-enriched meal increases serum ghrelin levels in healthy humans. Hormone and Metabolic Research. 2005;37(5):303–308.
    1. Tarini J, Wolever TMS. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. Applied Physiology, Nutrition and Metabolism. 2010;35(1):9–16.
    1. Sloth B, Davidsen L, Holst JJ, Flint A, Astrup A. Effect of subcutaneous injections of PYY1-36 and PYY 3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males. American Journal of Physiology. 2007;293(2):E604–E609.
    1. Hagander B, Asp NG, Efendic S. Reduced glycemic response to beet-fibre meal in non-insulin-dependent diabetics and its relation to plasma levels of pancreatic and gastrointestinal hormones. Diabetes Research. 1986;3(2):91–96.
    1. Shimada M, Date Y, Mondal MS, et al. Somatostatin suppresses ghrelin secretion from the rat stomach. Biochemical and Biophysical Research Communications. 2003;302(3):520–525.
    1. Nørrelund H, Hansen TK, Ørskov H, et al. Ghrelin immunoreactivity in human plasma is suppressed by somatostatin. Clinical Endocrinology. 2002;57(4):539–546.
    1. Lippl F, Kircher F, Erdmann J, Allescher HD, Schusdziarra V. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regulatory Peptides. 2004;119(1-2):93–98.
    1. Mälkki Y, Virtanen E. Gastrointestinal effects of oat bran and oat gum a review. Lebensmittel-Wissenschaft Technologie. 2001;34(6):337–347.
    1. Lanza E, Jones DY, Block G, Kessler L. Dietary fiber intake in the US population. American Journal of Clinical Nutrition. 1987;46(5):790–797.
    1. Anderson JW, Bridges SR, Tietyen J, Gustafson NJ. Dietary fiber content of a simulated American diet and selected research diets. American Journal of Clinical Nutrition. 1989;49(2):352–357.
    1. Tillotson JL, Bartsch GE, Gorder D, Grandits GA, Stamler J. Food group and nutrient intakes at baseline in the Multiple Risk Factor Intervention Trial. American Journal of Clinical Nutrition. 1997;65(1):228S–257S.
    1. Hallfrisch J, Tobin JD, Muller DC, Andres R. Fiber intake, age, and other coronary risk factors in men of the Baltimore Longitudinal Study (1959–1975) Journals of Gerontology. 1988;43(3):M64–M68.
    1. Hermann JR, Hanson CF, Kopel BH. Fiber intake of older adults: relationship to mineral intakes. Journal of Nutrition for the Elderly. 1992;11(4):21–33.
    1. Nova Scotia Department of Health, Report of the Nova Scotia Nutrition Survey, 1993.
    1. Schenkel TC, Stockman NKA, Brown JN, Duncan AM. Evaluation of energy, nutrient and dietary fiber intakes of adolescent males. Journal of the American College of Nutrition. 2007;26(3):264–271.
    1. Bagheri SM, Debry G. Evaluation of average daily consumption of dietary fiber in France. Annals of Nutrition and Metabolism. 1990;34(2):69–75.
    1. Arbman G, Axelson O, Ericsson-Begodzki AB, Fredriksson M, Nilsson E, Sjodahl R. Cereal fiber, calcium, and colorectal cancer. Cancer. 1992;69(8):2042–2048.
    1. Virtanen SM, Varo P. Dietary fibre and fibre fractions in the diet of Finnish diabetic and non-diabetic adolescents. European Journal of Clinical Nutrition. 1988;42(2):169–175.
    1. Pechanek U, Pfannhauser W. Examples of the fiber content of foods today. Zeitschrift fur die Gesamte Innere Medizin und Ihre Grenzgebiete. 1991;46(13):486–490.
    1. Hulshof KFAM, Lowik MRH, Kistemaker C, Hermus RJJ, Ten Hoor F, Ockhuizen T. Comparison of dietary intake data with guidelines: some potential pitfalls (Dutch nutrition surveillance system) Journal of the American College of Nutrition. 1993;12(2):176–185.
    1. Beer-Borst S, Wellauer-Weber B, Amado R. Dietary fiber intake of a Swiss collective interested in nutrition. Zeitschrift fur Ernahrungswissenschaft. 1994;33(1):68–78.
    1. Emmett PM, Symes CL, Heaton KW. Dietary intake and sources of non-starch polysaccharide in English men and women. European Journal of Clinical Nutrition. 1993;47(1):20–30.
    1. Tarrega A, Costell E. Effect of composition on the rheological behaviour and sensory properties of semisolid dairy dessert. Food Hydrocolloids. 2006;20(6):914–922.
    1. Tárrega A, Costell E. Effect of inulin addition on rheological and sensory properties of fat-free starch-based dairy desserts. International Dairy Journal. 2006;16(9):1104–1112.
    1. Villegas B, Costell E. Flow behaviour of inulin-milk beverages. Influence of inulin average chain length and of milk fat content. International Dairy Journal. 2007;17(7):776–781.
    1. Akalin AS, Karagözlü C, Ünal G. Rheological properties of reduced-fat and low-fat ice cream containing whey protein isolate and inulin. European Food Research and Technology. 2008;227(3):889–895.
    1. Aykan V, Sezgin E, Guzel-Seydim ZB. Use of fat replacers in the production of reduced-calorie vanilla ice cream. European Journal of Lipid Science and Technology. 2008;110(6):516–520.
    1. Karaca OB, Güven M, Yasar K, Kaya S, Kahyaoglu T. The functional, rheological and sensory characteristics of ice creams with various fat replacers. International Journal of Dairy Technology. 2009;62(1):93–99.
    1. Lazaridou A, Biliaderis CG, Micha-Screttas M, Steele BR. A comparative study on structure-function relations of mixed-linkage (1→3), (1→4) linear β-D-glucans. Food Hydrocolloids. 2004;18(5):837–855.
    1. Lee S, Inglett GE, Palmquist D, Warner K. Flavor and texture attributes of foods containing β-glucan-rich hydrocolloids from oats. Lebensmittel-Wissenschaft Technologie. 2009;42(1):350–357.
    1. Hunter KW, Gault RA, Berner MD. Preparation of microparticulate β-glucan from Saccharomyces cerevisiae for use in immune potentiation. Letters in Applied Microbiology. 2002;35(4):267–271.
    1. Kalinga D, Mishra VK. Rheological and physical properties of low fat cakes produced by addition of cereal β-glucan concentrates. Journal of Food Processing and Preservation. 2009;33(3):384–400.
    1. Tiwari U, Cummins E. Factors influencing β-glucan levels and molecular weight in cereal-based products. Cereal Chemistry. 2009;86(3):290–301.
    1. Saarela M, Virkajärvi I, Nohynek L, Vaari A, Mättö J. Fibres as carriers for Lactobacillus rhamnosus during freeze-drying and storage in apple juice and chocolate-coated breakfast cereals. International Journal of Food Microbiology. 2006;112(2):171–178.
    1. Gormley TR, Morrissey A. A note on the evaluation of wheaten breads containing oat flour or oat flakes. Irish Journal of Agricultural and Food Research. 1999;32:205–209.
    1. Inglett GE, Peterson SC, Carriere CJ, Maneepun S. Rheological, textural, and sensory properties of Asian noodles containing an oat cereal hydrocolloid. Food Chemistry. 2005;90(1-2):1–8.
    1. Fernández-García E, McGregor JU, Traylor S. The addition of oat fiber and natural alternative sweeteners in the manufacture of plain yogurt. Journal of Dairy Science. 1998;81(3):655–663.
    1. Konuklar G, Inglett GE, Warner K, Carriere CJ. Use of a β-glucan hydrocolloidal suspension in the manufacture of low-fat Cheddar cheeses: textural properties by instrumental methods and sensory panels. Food Hydrocolloids. 2004;18(4):535–545.
    1. Volikakis P, Biliaderis CG, Vamvakas C, Zerfiridis GK. Effects of a commercial oat-β-glucan concentrate on the chemical, physico-chemical and sensory attributes of a low-fat white-brined cheese product. Food Research International. 2004;37(1):83–94.
    1. Angelov A, Gotcheva V, Kuncheva R, Hristozova T. Development of a new oat-based probiotic drink. International Journal of Food Microbiology. 2006;112(1):75–80.
    1. Mårtensson O, Andersson C, Andersson K, Öste R, Holst O. Formulation of an oat-based fermented product and its comparison with yoghurt. Journal of the Science of Food and Agriculture. 2001;81(14):1314–1321.
    1. Troy DJ, Desmond EM, Buckley DJ. Eating quality of low-fat beef burgers containing fat-replacing functional blends. Journal of the Science of Food and Agriculture. 1999;79(4):507–516.
    1. Hughes E, Cofrades S, Troy DJ. Effects of fat level, oat fibre and carrageenan on frankfurters formulated with 5, 12 and 30% fat. Meat Science. 1997;45(3):273–281.
    1. Hilliam M. Future for dairy products and ingredients in the functional foods market. Australian Journal of Dairy Technology. 2003;58(2):98–103.
    1. Thebaudin JY, Lefebvre AC, Harrington M, Bourgeois CM. Dietary fibres: nutritional and technological interest. Trends in Food Science and Technology. 1997;8(2):41–48.
    1. Dello Staffolo M, Bertola N, Martino M, Bevilacqua A. Influence of dietary fiber addition on sensory and rheological properties of yogurt. International Dairy Journal. 2004;14(3):263–268.
    1. Johansson L, Tuomainen P, Anttila H, Rita H, Virkki L. Effect of processing on the extractability of oat β-glucan. Food Chemistry. 2007;105(4):1439–1445.
    1. Tosh SM, Brummer Y, Wolever TMS, Wood PJ. Glycemic response to oat bran muffins treated to vary molecular weight of β-glucan. Cereal Chemistry. 2008;85(2):211–217.
    1. Regand A, Tosh SM, Wolever TM, Wood PJ. Physicochemical properties of glucan in differently processed oat foods influence glycemie response. Journal of Agricultural and Food Chemistry. 2009;57(19):8831–8838.
    1. Degutyte-Fomins L, Sontag-Strohm T, Salovaara H. Oat bran fermentation by rye sourdough. Cereal Chemistry. 2002;79(3):345–348.
    1. Andersson AAM, Rüegg N, Åman P. Molecular weight distribution and content of water-extractable β-glucan in rye crisp bread. Journal of Cereal Science. 2008;47(3):399–406.
    1. Andersson AAM, Armö E, Grangeon E, Fredriksson H, Andersson R, Åman P. Molecular weight and structure units of (1→3, 1→4)-β-glucans in dough and bread made from hull-less barley milling fractions. Journal of Cereal Science. 2004;40(3):195–204.
    1. Frank J, Sundberg B, Kamal-Eldin A, Vessby B, Åman P. Yeast-leavened oat breads with high or low molecular weight β-glucan do not differ in their effects on blood concentrations of lipids, insulin, or glucose in humans. Journal of Nutrition. 2004;134(6):1384–1388.
    1. Lan-Pidhainey X. The physiochemical properties of oat B-glucan and its ability to attenuate postprandial glycaemic response. Department of Nutritional Sciences, University of Toronto, Canada: 2006. M.S. thesis.
    1. Institute of Medicine: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (Macronutrients), .
    1. Health and Welfare Canada, Report of the expert advisory committee on dietary fibre, 1985.
    1. Health Canada, Guideline concerning the safety and physiological effects of Novel fibre sources and food products containing them, 1988.
    1. European Food Safety Authority. Outcome of the public consultation on the draft opinion of the scientific panel on dietetic products, nutrition and allergies (NDA) on dietary reference values for carbohydrates and dietary fibre. EFSA Journal. 2010;8(5):p. 1508.
    1. FSANZ: Food Standards Code, Standard 1.2.8: Nutrition Information Requirements, .
    1. Health Canada: Proposed Policy: Definition and Energy Value for Dietary Fibre, .

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