Respiratory management in the patient with spinal cord injury

Rita Galeiras Vázquez, Pedro Rascado Sedes, Mónica Mourelo Fariña, Antonio Montoto Marqués, M Elena Ferreiro Velasco, Rita Galeiras Vázquez, Pedro Rascado Sedes, Mónica Mourelo Fariña, Antonio Montoto Marqués, M Elena Ferreiro Velasco

Abstract

Spinal cord injuries (SCIs) often lead to impairment of the respiratory system and, consequently, restrictive respiratory changes. Paresis or paralysis of the respiratory muscles can lead to respiratory insufficiency, which is dependent on the level and completeness of the injury. Respiratory complications include hypoventilation, a reduction in surfactant production, mucus plugging, atelectasis, and pneumonia. Vital capacity (VC) is an indicator of overall pulmonary function; patients with severely impaired VC may require assisted ventilation. It is best to proceed with intubation under controlled circumstances rather than waiting until the condition becomes an emergency. Mechanical ventilation can adversely affect the structure and function of the diaphragm. Early tracheostomy following short orotracheal intubation is probably beneficial in selected patients. Weaning should start as soon as possible, and the best modality is progressive ventilator-free breathing (PVFB). Appropriate candidates can sometimes be freed from mechanical ventilation by electrical stimulation. Respiratory muscle training regimens may improve patients' inspiratory function following a SCI.

References

    1. Brown R, DiMarco AF, Hoit JD, Garshick E. Respiratory dysfunction and management in spinal cord injury. Respiratory Care. 2006;51(8):853–868.
    1. Shavelle RM, DeVivo MJ, Strauss DJ, Paculdo DR, Lammertse DP, Day SM. Long-term survival of persons ventilator dependent after spinal cord injury. The Journal of Spinal Cord Medicine. 2006;29(5):511–519.
    1. Como JJ, Sutton ERH, McCunn M, et al. Characterizing the need for mechanical ventilation following cervical spinal cord injury with neurologic deficit. Journal of Trauma. 2005;59(4):912–916.
    1. DeVivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord. 2012;50(5):365–372.
    1. Jackson AB, Dijkers M, Devivo MJ, Poczatek RB. A demographic profile of new traumatic spinal cord injuries: change and stability over 30 years. Archives of Physical Medicine and Rehabilitation. 2004;85(11):1740–1748.
    1. Berlly M, Shem K. Respiratory management during the first five days after spinal cord injury. Journal of Spinal Cord Medicine. 2007;30(4):309–318.
    1. Medicine CfSC. Respiratory management following spinal cord injury: a clinical practice guideline for health-care professionals. Journal of Spinal Cord Medicine. 2005;28(3):259–293.
    1. de Paleville DGLT, McKay WB, Folz RJ, Ovechkin AV. Respiratory motor control disrupted by spinal cord injury: mechanisms, evaluation, and restoration. Translational Stroke Research. 2011;2(4):463–473.
    1. Schilero GJ, Spungen AM, Bauman WA, Radulovic M, Lesser M. Pulmonary function and spinal cord injury. Respiratory Physiology and Neurobiology. 2009;166(3):129–141.
    1. Linn WS, Spungen AM, Gong H, Jr., Adkins RH, Bauman A, Waters RL. Forced vital capacity in two large outpatient populations with chronic spinal cord injury. Spinal Cord. 2001;39(5):263–268.
    1. Goldman JM, Rose LS, Morgan MDL, Denison DM. Measurement of abdominal wall compliance in normal subjects and tetraplegic patients. Thorax. 1986;41(7):513–518.
    1. Deye N, Lellouche F, Maggiore SM, Taillé S, Demoule A, L'Her E, et al. The semi-seated position slightly reduces the effort to breathe during difficult weaning. Intensive Care Medicine. 2013;39(1):85–92.
    1. Dellamonica J, Lerolle N, Sargentini C, et al. PEEP-induced changes in lung volume in acute respiratory distress syndrome. Two methods to estimate alveolar recruitment. Intensive Care Medicine. 2013;39(6):1121–1127.
    1. Estenne M, De Troyer A. Mechanism of the postural dependence of vital capacity in tetraplegic subjects. American Review of Respiratory Disease. 1987;135(2):367–371.
    1. Ramakrishnan Bhaskar K, Brown R, O’Sullivan DD, Melia S, Duggan M, Reid L. Bronchial mucus hypersecretion in acute quadriplegia: macromolecular yields and glycoconjugate composition. American Review of Respiratory Disease. 1991;143(3):640–648.
    1. Spungen AM, Dicpinigaitis PV, Almenoff PL, Bauman WA. Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration. Paraplegia. 1993;31(6):404–407.
    1. Slonimski M, Aguilera EJ. Atelectasis and mucus plugging in spinal cord injury: case report and therapeutic approaches. Journal of Spinal Cord Medicine. 2001;24(4):284–288.
    1. Wong SL, Shem K, Crew J. Specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. Topics in Spinal Cord Injury Rehabilitation. 2012;18(4):283–290.
    1. Konrad F, Schreiber T, Brecht-Kraus D, Georgieff M. Mucociliary transport in ICU patients. Chest. 1994;105(1):237–241.
    1. Velmahos GC, Toutouzas K, Chan L, et al. Intubation after cervical spinal cord injury: to be done selectively or routinely? American Surgeon. 2003;69(10):891–894.
    1. Claxton AR, Wong DT, Chung F, Fehlings MG. Predictors of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury. Canadian Journal of Anaesthesia. 1998;45(2):144–149.
    1. Royster RA, Barboi C, Peruzzi WT. Critical care in the acute cervical spinal cord injury. Topics in Spinal Cord Injury Rehabilitation. 2004;9(3):11–32.
    1. Chiodo AE, Scelza W, Forchheimer M. Predictors of ventilator weaning in individuals with high cervical spinal cord injury. Journal of Spinal Cord Medicine. 2008;31(1):72–77.
    1. Matamis D, Soilemezi E, Tsagourias M, Akoumianaki E, Dimassi S, Boroli F, et al. Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications. Intensive Care Medicine. 2013;39(5):801–810.
    1. Sarwal A, Walker FO, Cartwright MS. Neuromuscular ultrasound for evaluation of the diaphragm. Muscle & Nerve. 2013;47(3):319–329.
    1. Vivier E, Mekontso Dessap A, Dimassi S, et al. Diaphragm ultrasonography to estimate the work of breathing during non-invasive ventilation. Intensive Care Medicine. 2012;38(5):796–803.
    1. Kim WY, Suh HJ, Hong S-B, Koh Y, Lim C-M. Diaphragm dysfunction assessed by ultrasonography: influence on weaning from mechanical ventilation. Critical Care Medicine. 2011;39(12):2627–2630.
    1. Wallbom AS, Naran B, Thomas E. Acute ventilator management and weaning in individuals with high tetraplegia. Topics in Spinal Cord Injury Rehabilitation. 2005;10(3):1–7.
    1. Jaber S, Petrof BJ, Jung B, et al. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. American Journal of Respiratory and Critical Care Medicine. 2011;183(3):364–371.
    1. Michaels AJ. Management of post traumatic respiratory failure. Critical Care Clinics. 2004;20(1):83–99.
    1. Girard TD, Bernard GR. Mechanical ventilation in ARDS: a state-of-the-art review. Chest. 2007;131(3):921–929.
    1. Petrof BJ, Jaber S, Matecki S. Ventilator-induced diaphragmatic dysfunction. Current Opinion in Critical Care. 2010;16(1):19–25.
    1. Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. American Journal of Respiratory and Critical Care Medicine. 2004;169(3):336–341.
    1. Levine S, Nguyen T, Taylor N, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. The New England Journal of Medicine. 2008;358(13):1327–1335.
    1. Haitsma JJ. Diaphragmatic dysfunction in mechanical ventilation. Current Opinion in Anaesthesiology. 2011;24(2):214–218.
    1. Sassoon CSH, Zhu E, Caiozzo VJ. Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. American Journal of Respiratory and Critical Care Medicine. 2004;170(6):626–632.
    1. Hermans G, Agten A, Testelmans D, Decramer M, Gayan-Ramirez G. Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Critical Care. 2010;14(4, article R127)
    1. Tobin MJ. Principles & Practice of Mechanical Ventilation. 2nd edition. New York, NY, USA: Courier Kendalville: McGraw-Hill; 2006.
    1. Thille AW, Rodriguez P, Cabello B, Lellouche F, Brochard L. Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Medicine. 2006;32(10):1515–1522.
    1. Nava S, Ambrosino N, Bruschi C, Confalonieri M, Rampulla C. Physiological effects of flow and pressure triggering during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease. Thorax. 1997;52(3):249–254.
    1. Sassoon CSH. Triggering of the ventilator in patient-ventilator interactions. Respiratory Care. 2011;56(1):39–48.
    1. Macintyre NR. Patient-ventilator interactions: optimizing conventional ventilation modes. Respiratory Care. 2011;56(1):73–81.
    1. Lellouche F, Brochard L. Advanced closed loops during mechanical ventilation (PAV, NAVA, ASV, SmartCare) Best Practice and Research. 2009;23(1):81–93.
    1. Verbrugghe W, Jorens PG. Neurally adjusted ventilatory assist: a ventilation tool or a ventilation toy? Respiratory Care. 2011;56(3):327–335.
    1. Peterson WP, Barbalata L, Brooks CA, Gerhart KA, Mellick DC, Whiteneck GG. The effect of tidal volumes on the time to wean persons with high tetraplegia from ventilators. Spinal Cord. 1999;37(4):284–288.
    1. Fenton J, Warner M, Charlifue S, Lammertse D, Dannels-McClure A, Lonnie M, et al. A comparison of high vs. standard tidal volumes in ventilator weaning for individuals with subacute cervical spine cord injuries: a site-specific randomized clinical trial. Chest. 2011;140(Abstracts 403A)
    1. Crew JD, Svircev JN, Burns SP. Mechanical insufflation-exsufflation device prescription for outpatients with tetraplegia. Journal of Spinal Cord Medicine. 2010;33(2):128–134.
    1. Schmitt JK, Stiens S, Trincher R, et al. Survey of use of the insufflator-exsufflator in patients with spinal cord injury. Journal of Spinal Cord Medicine. 2007;30(2):127–130.
    1. Salman D, Finney SJ, Griffiths MJ. Strategies to reduce ventilator-associated lung injury (VALI) Burns. 2013;39(2):200–211.
    1. Berney S, Bragge P, Granger C, Opdam H, Denehy L. The acute respiratory management of cervical spinal cord injury in the first 6 weeks after injury: a systematic review. Spinal Cord. 2011;49(1):17–29.
    1. Peterson W, Charlifue W, Gerhart A, Whiteneck G. Two methods of weaning persons with quadriplegia from mechanical ventilators. Paraplegia. 1994;32(2):98–103.
    1. Ayas NT, McCool FD, Gore R, Lieberman SL, Brown R. Prevention of human diaphragm atrophy with short periods of electrical stimulation. American Journal of Respiratory and Critical Care Medicine. 1999;159(6):2018–2020.
    1. Gutierrez CJ, Stevens C, Merritt J, Pope C, Tanasescu M, Curtiss G. Trendelenburg chest optimization prolongs spontaneous breathing trials in ventilator-dependent patients with low cervical spinal cord injury. Journal of Rehabilitation Research and Development. 2010;47(3):261–272.
    1. Weinberger SE, Weiss JW. Weaning from ventilatory support. The New England Journal of Medicine. 1995;332(6):388–389.
    1. Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. American Journal of Respiratory and Critical Care Medicine. 1994;150(4):896–903.
    1. Esteban A, Frutos F, Tobin MJ, Alía I, Solsona JF, Valverdú I, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. The New England Journal of Medicine. 1995;332(6):345–350.
    1. Jubran A, Grant BJ, Duffner LA, Collins EG, Lanuza DM, Hoffman LA, et al. Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial. The Journal of the American Medical Association. 2013;309(7):671–677.
    1. Gutierrez CJ, Harrow J, Haines F. Using an evidence-based protocol to guide rehabilitation and weaning of ventilator-dependent cervical spinal cord injury patients. Journal of Rehabilitation Research and Development. 2003;40(5, supplement 2):99–110.
    1. Atito-Narh E, Pieri-Davies S, Watt JWH. Slow ventilator weaning after cervical spinal cord injury. British Journal of Intensive Care. 2008;18(3):95–103.
    1. Bach JR, Saporito LR. Criteria for extubation and tracheostomy tuba removal for patients with ventilatory failure: a different approach to weaning. Chest. 1996;110(6):1566–1571.
    1. Bach JR. Noninvasive respiratory management and diaphragm and electrophrenic pacing in neuromuscular disease and spinal cord injury. Muscle & Nerve. 2013;47(2):297–305.
    1. Tromans AM, Mecci M, Barrett FH, Ward TA, Grundy DJ. The use of the BiPAP biphasic positive airway pressure system in acute spinal cord injury. Spinal Cord. 1998;36(7):481–484.
    1. Bach JR. Continuous noninvasive ventilation for patients with neuromuscular disease and spinal cord injury. Seminars in Respiratory and Critical Care Medicine. 2002;23(3):283–292.
    1. Bach JR. Noninvasive respiratory management of high level spinal cord injury. Journal of Spinal Cord Medicine. 2012;35(2):72–80.
    1. Glenn WWL, Hogan JF, Loke JSO. Ventilatory support by pacing of the conditioned diaphragm in quadriplegia. The New England Journal of Medicine. 1984;310(18):1150–1155.
    1. Hirschfeld S, Exner G, Luukkaala T, Baer GA. Mechanical ventilation or phrenic nerve stimulation for treatment of spinal cord injury-induced respiratory insufficiency. Spinal Cord. 2008;46(11):738–742.
    1. Romero-Ganuza FJ, Gambarrutta-Malfatti C, Diez de la Lastra-Buigues E, et al. Diaphragmatic pacemaker as an alternative to mechanical ventilation in patients with cervical spinal injury. Medicina Intensiva. 2011;35(1):13–21.
    1. Onders RP, Elmo M, Khansarinia S, et al. Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients. Surgical Endoscopy and other Interventional Techniques. 2009;23(7):1433–1440.
    1. DiMarco AF, Kowalski KE. Intercostal muscle pacing with high frequency spinal cord stimulation in dogs. Respiratory Physiology and Neurobiology. 2010;171(3):218–224.
    1. Grimm DR, Schilero GJ, Spungen AM, Bauman WA, Lesser M. Salmeterol improves pulmonary function in persons with tetraplegia. Lung. 2006;184(6):335–339.
    1. Bascom AT, Lattin CD, Aboussouan LS, Goshgarian HG. Effect of acute aminophylline administration on diaphragm function in high cervical tetraplegia: a case report. Chest. 2005;127(2):658–661.
    1. Spungen AM, Grimm DR, Strakhan M, Pizzolato PM, Bauman WA. Treatment with an anabolic agent is associated with improvement in respiratory function in persons with tetraplegia: a pilot study. Mount Sinai Journal of Medicine. 1999;66(3):201–205.
    1. Hassid VJ, Schinco MA, Tepas JJ, et al. Definitive establishment of airway control is critical for optimal outcome in lower cervical spinal cord injury. The Journal of Trauma. 2008;65(6):1328–1332.
    1. Nakashima H, Yukawa Y, Imagama S, Ito K, Hida T, Machino M, et al. Characterizing the need for tracheostomy placement and decannulation after cervical spinal cord injury. European Spine Journal. 2013;22(7):1526–1532.
    1. Harrop JS, Sharan AD, Scheid EH, Jr., Vaccaro AR, Przybylski GJ. Tracheostomy placement in patients with complete cervical spinal cord injuries: American Spinal Injury Association Grade A. Journal of Neurosurgery. 2004;100(1, supplement):20–23.
    1. Seidl RO, Wolf D, Nusser-Müller-Busch R, Niedeggen A. Airway management in acute tetraplegics: a retrospective study. European Spine Journal. 2010;19(7):1073–1078.
    1. Branco BC, Plurad D, Green DJ, et al. Incidence and clinical predictors for tracheostomy after cervical spinal cord injury: a national trauma databank review. Journal of Trauma. 2011;70(1):111–115.
    1. Cotton BA, Pryor JP, Chinwalla I, Wiebe DJ, Reilly PM, Schwab CW. Respiratory complications and mortality risk associated with thoracic spine injury. The Journal of trauma. 2005;59(6):1400–1409.
    1. Winslow C, Bode RK, Felton D, Chen D, Meyer PR., Jr. Impact of respiratory complications on length of stay and hospital costs in acute cervical spine injury. Chest. 2002;121(5):1548–1554.
    1. Ganuza JR, Forcada AG, Gambarrutta C, et al. Effect of technique and timing of tracheostomy in patients with acute traumatic spinal cord injury undergoing mechanical ventilation. Journal of Spinal Cord Medicine. 2011;34(1):76–84.
    1. Leelapattana P, Fleming JC, Gurr KR, Bailey SI, Parry N, Bailey CS. Predicting the need for tracheostomy in patients with cervical spinal cord injury. Journal of Trauma- Injury, Infection, and Critical Care. 2012;73(4):880–884.
    1. Sims CA, Berger DL. Airway risk in hospitalized trauma patients with cervical injuries requiring halo fixation. Annals of Surgery. 2002;235(2):280–284.
    1. Nun AB, Orlovsky M, Best LA. Percutaneous tracheostomy in patients with cervical spine fractures—feasible and safe. Interactive Cardiovascular and Thoracic Surgery. 2006;5(4):427–429.
    1. Mallick A, Bodenham AR. Tracheostomy in critically ill patients. European Journal of Anaesthesiology. 2010;27(8):676–682.
    1. Šustić A, Krstulović B, Eškinja N, Zelić M, Ledić D, Turina D. Surgical tracheostomy versus percutaneous dilational tracheostomy in patients with anterior cervical spine fixation: preliminary report. Spine. 2002;27(17):1942–1945.
    1. Babu R, Owens TR, Thomas S, Karikari IO, Grunch BH, Moreno JR, et al. Timing of tracheostomy after anterior cervical spine fixation. Journal of Trauma & Acute Care Surgery. 2013;74(4):961–966.
    1. O’Keeffe T, Goldman RK, Mayberry JC, Rehm CG, Hart RA. Tracheostomy after anterior cervical spine fixation. Journal of Trauma. 2004;57(4):855–860.
    1. Ball PA. Critical care of spinal cord injury. Spine. 2001;26(24, supplement):S27–S30.
    1. Tran NV, Vernick J, Cotler JM, Rabinovici R. Lateral tracheostomy in patients with cervical spinal cord injury. British Journal of Surgery. 1995;82(3):412–413.
    1. Ceriana P, Carlucci A, Navalesi P, et al. Physiological responses during a T-piece weaning trial with a deflated tube. Intensive Care Medicine. 2006;32(9):1399–1403.
    1. Hernandez G, Pedrosa A, Ortiz R, Cruz AMM, Cuena R, Vaquero Collado C, et al. The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial. Intensive Care Medicine. 2013;39(6):1063–1070.
    1. Shah A, Shem K, McKenna S, Berlly M. Respiratory management of the spinal cord-injured patient. In: Campagnolo DI, Kirshblum S, editors. Spinal Cord Medicine. Philadelphia, Pa, USA: Lippincott Williams & Wilkins; 2011. pp. 155–173.
    1. Barratt DJ, Harvey LA, Cistulli PA, Nier L, Denis S. The use of bronchodilators in people with recently acquired tetraplegia: a randomised cross-over trial. Spinal Cord. 2012;50(11):836–839.
    1. Mateus SRM, Beraldo PSS, Horan TA. Cholinergic bronchomotor tone and airway caliber in tetraplegic patients. Spinal Cord. 2006;44(5):269–274.
    1. Gómez-Merino E, Sancho J, Marín J, et al. Mechanical insufflation-exsufflation: pressure, volume, and flow relationships and the adequacy of the manufacturer’s guidelines. American Journal of Physical Medicine and Rehabilitation. 2002;81(8):579–583.
    1. Pillastrini P, Bordini S, Bazzocchi G, Belloni G, Menarini M. Study of the effectiveness of bronchial clearance in subjects with upper spinal cord injuries: examination of a rehabilitation programme involving mechanical insufflation and exsufflation. Spinal Cord. 2006;44(10):614–616.
    1. Sheel AW, Reid WD, Townson AF, Ayas NT, Konnyu KJ. Effects of exercise training and inspiratory muscle training in spinal cord injury: a systematic review. Journal of Spinal Cord Medicine. 2008;31(5):500–508.
    1. Mueller G, Hopman MT, Perret C. Comparison of respiratory muscle training methods in individuals with motor and sensory complete tetraplegia: a randomized controlled trial. Journal of Rehabilitation Medicine. 2013;45(3):248–253.
    1. Harvey L. Respiratory manegement. In: Harvey L, editor. Management of Spinal Cord Injuries, A Guide for Physiotherapists. Philadelphia, Pa, USA: Elsevier; 2008. pp. 205–225.
    1. DiMarco AF. Restoration of respiratory muscle function following spinal cord injury: review of electrical and magnetic stimulation techniques. Respiratory Physiology and Neurobiology. 2005;147(2-3):273–287.
    1. Arora S, Flower O, Murray NP, Lee BB. Respiratory care of patients with cervical spinal cord injury: a review. Critical Care and Resuscitation. 2012;14(1):64–73.
    1. Garret B, Shatzer H, Bach J. Respiratory treatment and equipment. In: Sisto SA, Druin E, Sliwinski MM, editors. Spinal Cord Injuries. St. Louis, Mo, USA: Mosby; 2009. pp. 69–102.
    1. Miller HJ, Thomas E, Wilmot CB. Pneumobelt use among high quadriplegic population. Archives of Physical Medicine and Rehabilitation. 1988;69(5):369–372.

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