ICBT in routine care: A descriptive analysis of successful clinics in five countries

Nickolai Titov, Blake Dear, Olav Nielssen, Lauren Staples, Heather Hadjistavropoulos, Marcie Nugent, Kelly Adlam, Tine Nordgreen, Kristin Hogstad Bruvik, Anders Hovland, Arne Repål, Kim Mathiasen, Martin Kraepelien, Kerstin Blom, Cecilia Svanborg, Nils Lindefors, Viktor Kaldo, Nickolai Titov, Blake Dear, Olav Nielssen, Lauren Staples, Heather Hadjistavropoulos, Marcie Nugent, Kelly Adlam, Tine Nordgreen, Kristin Hogstad Bruvik, Anders Hovland, Arne Repål, Kim Mathiasen, Martin Kraepelien, Kerstin Blom, Cecilia Svanborg, Nils Lindefors, Viktor Kaldo

Abstract

Clinical trials have demonstrated the efficacy of internet delivered cognitive behaviour therapy (ICBT) for anxiety and depression. However, relatively little is known about the context, operations, and outcomes of ICBT when administered as part of routine care. This paper describes the setting, relationship to existing health services, procedures for referral, assessment, treatment, patients and outcomes of ICBT clinics in Sweden, Denmark, Norway, Canada and Australia. All five clinics provide services free or at low cost to patients. All have systems of governance to monitor quality of care, patient safety, therapist performance and data security. All five clinics include initial assessments by clinicians and between 10 and 20 min of therapist support during each week. Published reports of outcomes all demonstrate large clinical improvement, low rates of deterioration, and high levels of patient satisfaction. Services that require a face to face assessment treat smaller numbers of patients and have fewer patients from remote locations. The paper shows that therapist-guided ICBT can be a valuable part of mental health services for anxiety and depression. Important components of successful ICBT services are rigorous governance to maintain a high standard of clinical care, and the measurement and reporting of outcomes.

Keywords: Anxiety; Delivery; Depression; Description; Disorders; Implementation; Internet-delivered cognitive behaviour therapy; Psychological treatment; Routine care.

References

    1. Andersson G., Hedman E. Effectiveness of guided Internet-delivered cognitive behaviour therapy in regular clinical settings. Verhaltenstherapie. 2013;23:140–148.
    1. Andersson G., Titov N. Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry. 2014;13(1):4–11.
    1. Andersson G., Bergstrom J., Hollandare F., Carlbring P., Kaldo V., Ekselius L. Internet-based self-help for depression: randomised controlled trial. Br. J. Psychiatry. 2005;187:456–461.
    1. Andersson G., Carlbring P., Holmstrom A., Sparthan E., Furmark T., Nilsson-Ihrfelt E., Buhrman M., Ekselius L. Internet-based self-help with therapist feedback and in vivo group exposure for social phobia: a randomized controlled trial. J. Consult. Clin. Psychol. 2006;74(4):677–686.
    1. Andersson G., Cuijpers P., Carlbring P., Riper H., Hedman E. Guided Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: a systematic review and meta-analysis. World Psychiatry. 2014;13(3):288–295.
    1. Andrews G., Cuijpers P., Craske M.G., McEvoy P., Titov N. Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis. PLoS One. 2010;5(10)
    1. Bee P.E., Bower P., Lovell K., Gilbody S., Richards D., Gask L., Roach P. Psychotherapy mediated by remote communication technologies: a meta-analytic review. BMC Psychiatry. 2008;8:60.
    1. Bergstrom J., Andersson G., Ljotsson B., Ruck C., Andreewitch S., Karlsson A., Carlbring P., Andersson E., Lindefors N. Internet- versus group-administered cognitive behaviour therapy for panic disorder in a psychiatric setting: a randomised trial. BMC Psychiatry. 2010;10:54.
    1. Carlbring P., Gunnarsdottir M., Hedensjo L., Andersson G., Ekselius L., Furmark T. Treatment of social phobia: randomised trial of internet-delivered cognitive-behavioural therapy with telephone support. Br. J. Psychiatry. 2007;190:123–128.
    1. Christensen H., Griffiths K.M., Mackinnon A.J., Brittliffe K. Online randomized controlled trial of brief and full cognitive behaviour therapy for depression. Psychol. Med. 2006;36(12):1737–1746.
    1. Clark D.M., Canvin L., Green J., Layard R., Pilling S., Janecka M. Transparency about the outcomes of mental health services (IAPT approach): an analysis of public data. Lancet. 2018;391(10121):679–686.
    1. Cuijpers P., van Straten A., Andersson G., van Oppen P. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J. Consult. Clin. Psychol. 2008;76(6):909–922.
    1. Cuijpers P., Marks I.M., van Straten A., Cavanagh K., Gega L., Andersson G. Computer-aided psychotherapy for anxiety disorders: a meta-analytic review. Cogn. Behav. Ther. 2009;38(2):66–82.
    1. Cuijpers P., Donker T., van Straten A., Li J., Andersson G. Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies. Psychol. Med. 2010;40(12):1943–1957.
    1. Damschroder L.J., Aron D.C., Keith R.E., Kirsh S.R., Alexander J.A., Lowery J.C. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement. Sci. 2009;4:50.
    1. Dear B.F., Titov N., Perry K.N., Johnston L., Wootton B.M., Terides M.D., Rapee R.M., Hudson J.L. The pain course: a randomised controlled trial of a clinician-guided internet-delivered cognitive behaviour therapy program for managing chronic pain and emotional well-being. Pain. 2013;154(6):942–950.
    1. Dear B.F., Staples L.G., Terides M.D., Karin E., Zou J., Johnston L., Gandy M., Fogliati V.J., Wootton B.M., McEvoy P.M., Titov N. Transdiagnostic versus disorder-specific and clinician-guided versus self-guided internet-delivered treatment for generalized anxiety disorder and comorbid disorders: a randomized controlled trial. J. Anxiety Disord. 2015;36:63–77.
    1. Dear B.F., Staples L.G., Terides M.D., Fogliati V.J., Sheehan J., Johnston L., Kayrouz R., Dear R., McEvoy P.M., Titov N. Transdiagnostic versus disorder-specific and clinician-guided versus self-guided internet-delivered treatment for Social Anxiety Disorder and comorbid disorders: a randomized controlled trial. J. Anxiety Disord. 2016;42:30–44.
    1. Dear B.F., Fogliati V.J., Fogliati R., Johnson B., Boyle O., Karin E., Gandy M., Kayrouz R., Staples L.G., Titov N. Treating anxiety and depression in young adults: a randomised controlled trial comparing clinician-guided versus self-guided Internet-delivered cognitive behavioural therapy. Aust. N. Z. J. Psychiatry. 2017;52(7):668–679.
    1. El Alaoui S., Hedman E., Kaldo V., Hesser H., Kraepelien M., Andersson E., Ruck C., Andersson G., Ljotsson B., Lindefors N. Effectiveness of Internet-based cognitive-behavior therapy for social anxiety disorder in clinical psychiatry. J. Consult. Clin. Psychol. 2015;83(5):902–914.
    1. El Alaoui S., Hedman E., Ljotsson B., Lindefors N. Long-term effectiveness and outcome predictors of therapist-guided internet-based cognitive-behavioural therapy for social anxiety disorder in routine psychiatric care. BMJ Open. 2015;5(6)
    1. Erbe D., Eichert H.C., Riper H., Ebert D.D. Blending face-to-face and internet-based interventions for the treatment of mental disorders in adults: systematic review. J. Med. Internet Res. 2017;19(9)
    1. Fogliati V.J., Terides M.D., Gandy M., Staples L.G., Johnston L., Karin E., Rapee R.M., Titov N., Dear B.F. Psychometric properties of the Mini-Social Phobia Inventory (Mini-SPIN) in a large online treatment-seeking sample. Cogn. Behav. Ther. 2016;45(3):236–257.
    1. Folker A.P., Mathiasen K., Lauridsen S.M., Stenderup E., Dozeman E., Folker M.P. Implementing internet-delivered cognitive behavior therapy for common mental health disorders: a comparative case study of implementation challenges perceived by therapists and managers in five European internet services. Internet Interv. 2018;11:60–70.
    1. Gaglio B., Shoup J.A., Glasgow R.E. The RE-AIM framework: a systematic review of use over time. Am. J. Public Health. 2013;103(6):e38–e46.
    1. Gilbody S., Littlewood E., Hewitt C., Brierley G., Tharmanathan P., Araya R., Barkham M., Bower P., Cooper C., Gask L., Kessler D., Lester H., Lovell K., Parry G., Richards D.A., Andersen P., Brabyn S., Knowles S., Shepherd C., Tallon D., White D. Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial. BMJ. 2015;351:h5627.
    1. Hadjistavropoulos H.D., Nugent M.M., Alberts N.M., Staples L., Dear B.F., Titov N. Transdiagnostic Internet-delivered cognitive behaviour therapy in Canada: an open trial comparing results of a specialized online clinic and nonspecialized community clinics. J. Anxiety Disord. 2016;42:19–29.
    1. Hadjistavropoulos H.D., Nugent M.M., Dirkse D., Pugh N. Implementation of internet-delivered cognitive behavior therapy within community mental health clinics: a process evaluation using the consolidated framework for implementation research. BMC Psychiatry. 2017;17(1):331.
    1. Hadjistavropoulos H.D., Schneider L.H., Klassen K., Dear B.F., Titov N. Development and evaluation of a scale assessing therapist fidelity to guidelines for delivering therapist-assisted Internet-delivered cognitive behaviour therapy. Cogn. Behav. Ther. 2018:1–15.
    1. Hedman E., Ljótsson B., Andersson E., Rück C., Andersson G., Lindefors N. Effectiveness and cost offset analysis of group CBT for hypochondriasis delivered in a psychiatric setting: an open trial. Cogn. Behav. Ther. 2010;39(4):239–250.
    1. Hedman E., Ljotsson B., Lindefors N. Cognitive behavior therapy via the Internet: a systematic review of applications, clinical efficacy and cost-effectiveness. Expert Rev. Pharmacoecon. Outcomes Res. 2012;12(6):745–764.
    1. Hedman E., Ljotsson B., Ruck C., Bergstrom J., Andersson G., Kaldo V., Jansson L., Andersson E., Andersson E., Blom K., El Alaoui S., Falk L., Ivarsson J., Nasri B., Rydh S., Lindefors N. Effectiveness of internet-based cognitive behaviour therapy for panic disorder in routine psychiatric care. Acta Psychiatr. Scand. 2013;128(6):457–467.
    1. Hedman E., Ljotsson B., Kaldo V., Hesser H., El Alaoui S., Kraepelien M., Andersson E., Ruck C., Svanborg C., Andersson G., Lindefors N. Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care. J. Affect. Disord. 2014;155:49–58.
    1. Hobbs M.J., Mahoney A.E.J., Andrews G. Integrating iCBT for generalized anxiety disorder into routine clinical care: treatment effects across the adult lifespan. J. Anxiety Disord. 2017;51:47–54.
    1. Johnston L., Dear B.F., Gandy M., Fogliati V.J., Kayrouz R., Sheehan J., Rapee R.M., Titov N. Exploring the efficacy and acceptability of Internet-delivered cognitive behavioural therapy for young adults with anxiety and depression: an open trial. Aust. N. Z. J. Psychiatry. 2014;48(9):819–827.
    1. Kaldo V., Jernelov S., Blom K., Ljotsson B., Brodin M., Jorgensen M., Kraepelien M., Ruck C., Lindefors N. Guided internet cognitive behavioral therapy for insomnia compared to a control treatment - a randomized trial. Behav. Res. Ther. 2015;71:90–100.
    1. Kaldo-Sandstrom V., Larsen H.C., Andersson G. Internet-based cognitive-behavioral self-help treatment of tinnitus: clinical effectiveness and predictors of outcome. Am. J. Audiol. 2004;13(2):185–192.
    1. Kenter R.M.F., van de Ven P.M., Cuijpers P., Koole G., Niamat S., Gerrits R.S., Willems M., van Straten A. Costs and effects of Internet cognitive behavioral treatment blended with face-to-face treatment: results from a naturalistic study. Internet Interv. 2015;2(1):77–83.
    1. Kivi M., Eriksson M.C.M., Hange D., Petersson E.-L., Vernmark K., Johansson B., Björkelund C. Internet-based therapy for mild to moderate depression in Swedish primary care: short term results from the PRIM-NET randomized controlled trial. Cogn. Behav. Ther. 2014;43(4):289–298.
    1. Klein B., Meyer D., Austin D.W., Kyrios M. Anxiety online: a virtual clinic: preliminary outcomes following completion of five fully automated treatment programs for anxiety disorders and symptoms. J. Med. Internet Res. 2011;13(4)
    1. Lee Y.C., Gao L., Dear B.F., Titov N., Mihalopoulos C. The cost-effectiveness of the online MindSpot Clinic for the treatment of depression and anxiety in Australia. J. Ment. Health Policy Econ. 2017;20(4):155–166.
    1. Ljotsson B., Hedman E., Andersson E., Hesser H., Lindfors P., Hursti T., Rydh S., Ruck C., Lindefors N., Andersson G. Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: a randomized trial. Am. J. Gastroenterol. 2011;106(8):1481–1491.
    1. Marks I.M., Kenwright M., McDonough M., Whittaker M., Mataix-Cols D. Saving clinicians' time by delegating routine aspects of therapy to a computer: a randomized controlled trial in phobia/panic disorder. Psychol. Med. 2004;34(1):9–17.
    1. Mathiasen K., Riper H., Ehlers L.H., Valentin J.B., Rosenberg N.K. Internet-based CBT for social phobia and panic disorder in a specialised anxiety clinic in routine care: results of a pilot randomised controlled trial. Internet Interv. 2016;4:92–98.
    1. Mathiasen K., Riper H., Andersen T.E., Roessler K.K. 2018. Evaluation of Clinical Effect in Routine Secondary Care of Guided Internet Based CBT for Adult Depression and Anxiety: An Observational Study. JMIR Preprints. 01/05/2018:10927.
    1. Mohr D.C., Weingardt K.R., Reddy M., Schueller S.M. Three problems with current digital mental health research … and three things we can do about them. Psychiatr. Serv. 2017;68(5):427–429.
    1. Mojtabai R., Olfson M., Sampson N.A., Jin R., Druss B., Wang P.S., Wells K.B., Pincus H.A., Kessler R.C. Barriers to mental health treatment: results from the National Comorbidity Survey Replication. Psychol. Med. 2011;41(8):1751–1761.
    1. National Health and Medical Research Council Phases of clinical trials. 2015. Retrieved 24.07.2018, from.
    1. National Institutes of Health NIH clinical research trials and you. 2017. Retrieved 24.07.2018, from.
    1. Newby J.M., Twomey C., Yuan Li S.S., Andrews G. Transdiagnostic computerised cognitive behavioural therapy for depression and anxiety: a systematic review and meta-analysis. J. Affect. Disord. 2016;199:30–41.
    1. Newby J.M., Mewton L., Andrews G. Transdiagnostic versus disorder-specific internet-delivered cognitive behaviour therapy for anxiety and depression in primary care. J. Anxiety Disord. 2017;46:25–34.
    1. Nielssen O., Dear B.F., Staples L.G., Dear R., Ryan K., Purtell C., Titov N. Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of anxiety and depression. BMC Psychiatry. 2015;15:304.
    1. Nordgreen T., Standal B., Mannes H., Haug T., Sivertsen B., Carlbring P., Andersson G., Heiervang E., Havik O.E. Guided self-help via internet for panic disorder: dissemination across countries. Comput. Hum. Behav. 2010;26(4):592–596.
    1. Nordgreen T., Haug T., Ost L.G., Andersson G., Carlbring P., Kvale G., Tangen T., Heiervang E., Havik O.E. Stepped care versus direct face-to-face cognitive behavior therapy for social anxiety disorder and panic disorder: a randomized effectiveness trial. Behav. Ther. 2016;47(2):166–183.
    1. Nordgreen T., Gjestad R., Andersson G., Carlbring P., Havik O.E. The implementation of guided Internet-based cognitive behaviour therapy for panic disorder in a routine-care setting: effectiveness and implementation efforts. Cogn. Behav. Ther. 2018;47(1):62–75.
    1. Nordgreen, T., R. Gjestad, G. Andersson, P. Carlbring and O. E. Havik The effectiveness of guided internet-based cognitive behavioral therapy for social anxiety disorder in a routine care setting. Internet Interv. 13, 24–29.
    1. Nordmo M., Sinding A.I., Carlbring P., Andersson G., Havik O.E., Nordgreen T. Internet-delivered cognitive behavioural therapy with and without an initial face-to-face psychoeducation session for social anxiety disorder: a pilot randomized controlled trial. Internet Interv. 2015;2(4):429–436.
    1. Olthuis J.V., Watt M.C., Bailey K., Hayden J.A., Stewart S.H. Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults. Cochrane Database Syst. Rev. 2016;3
    1. Proudfoot J., Clarke J., Birch M.R., Whitton A.E., Parker G., Manicavasagar V., Harrison V., Christensen H., Hadzi-Pavlovic D. Impact of a mobile phone and web program on symptom and functional outcomes for people with mild-to-moderate depression, anxiety and stress: a randomised controlled trial. BMC Psychiatry. 2013;13:312.
    1. Richards D.A., Borglin G. Implementation of psychological therapies for anxiety and depression in routine practice: two year prospective cohort study. J. Affect. Disord. 2011;133(1–2):51–60.
    1. Richards D., Richardson T. Computer-based psychological treatments for depression: a systematic review and meta-analysis. Clin. Psychol. Rev. 2012;32(4):329–342.
    1. Richards D., Vigano N., O'Callaghan D.D., O'Brien E., Mooney J., Bonner C. Towards a gold standard for internet-delivered programs in behavioral and mental health. Eur. Psychiatry. 2016;33:S610.
    1. Ruwaard J., Kok R. Wild west eHealth: time to hold our horses? Eur. Health Psychol. 2015;17(1):45–49.
    1. Ruwaard J., Lange A., Schrieken B., Emmelkamp P. Efficacy and effectiveness of online cognitive behavioral treatment: a decade of interapy research. Stud. Health Technol. Inform. 2011;167:9–14.
    1. Ruwaard J., Lange A., Schrieken B., Dolan C.V., Emmelkamp P. The effectiveness of online cognitive behavioral treatment in routine clinical practice. PLoS One. 2012;7(7)
    1. Simblett S., Birch J., Matcham F., Yaguez L., Morris R. A systematic review and meta-analysis of e-mental health interventions to treat symptoms of posttraumatic stress. JMIR Ment. Health. 2017;4(2)
    1. Spence J., Titov N., Johnston L., Jones M.P., Dear B.F., Solley K. Internet-based trauma-focused cognitive behavioural therapy for PTSD with and without exposure components: a randomised controlled trial. J. Affect. Disord. 2014;162:73–80.
    1. Staples L.G., Fogliati V.J., Dear B.F., Nielssen O., Titov N. Internet-delivered treatment for older adults with anxiety and depression: implementation of the Wellbeing Plus Course in routine clinical care and comparison with research trial outcomes. BJPsych Open. 2016;2(5):307–313.
    1. Titov N., Dear B.F., Johnston L., Lorian C., Zou J., Wootton B., Spence J., McEvoy P.M., Rapee R.M. Improving adherence and clinical outcomes in self-guided internet treatment for anxiety and depression: randomised controlled trial. PLoS One. 2013;8(7)
    1. Titov N., Dear B.F., Staples L.G., Bennett-Levy J., Klein B., Rapee R.M., Shann C., Richards D., Andersson G., Ritterband L., Purtell C., Bezuidenhout G., Johnston L., Nielssen O.B. MindSpot clinic: an accessible, efficient, and effective online treatment service for anxiety and depression. Psychiatr. Serv. 2015;66(10):1043–1050.
    1. Titov N., Dear B.F., Staples L.G., Terides M.D., Karin E., Sheehan J., Johnston L., Gandy M., Fogliati V.J., Wootton B.M., McEvoy P.M. Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: a randomized controlled trial. J. Anxiety Disord. 2015;35:88–102.
    1. Titov N., Dear B.F., Staples L.G., Bennett-Levy J., Klein B., Rapee R.M., Andersson G., Purtell C., Bezuidenhout G., Nielssen O.B. The first 30 months of the MindSpot Clinic: evaluation of a national e-mental health service against project objectives. Aust. N. Z. J. Psychiatry. 2017;51(12):1227–1239.
    1. Titov N., Hadjistavropoulos H., Nordgreen T., Kaldo V., Mathiasen K. 9th Scientific Meeting of the International Society for Research into Internet Interventions, Berlin, Germany. 2017. Models of ICBT in routine care across five countries.
    1. Twomey C., O'Reilly G., Byrne M. Effectiveness of cognitive behavioural therapy for anxiety and depression in primary care: a meta-analysis. Fam. Pract. 2015;32(1):3–15.
    1. Wang P.S., Aguilar-Gaxiola S., Alonso J., Angermeyer M.C., Borges G., Bromet E.J., Bruffaerts R., de Girolamo G., de Graaf R., Gureje O., Haro J.M., Karam E.G., Kessler R.C., Kovess V., Lane M.C., Lee S., Levinson D., Ono Y., Petukhova M., Posada-Villa J., Seedat S., Wells J.E. Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. Lancet. 2007;370(9590):841–850.
    1. Whiteford H.A., Buckingham W.J., Harris M.G., Burgess P.M., Pirkis J.E., Barendregt J.J., Hall W.D. Estimating treatment rates for mental disorders in Australia. Aust. Health Rev. 2014;38(1):80–85.
    1. Williams A.D., Andrews G. The effectiveness of Internet cognitive behavioural therapy (iCBT) for depression in primary care: a quality assurance study. PLoS One. 2013;8(2)
    1. Wootton B.M., Dear B.F., Johnston L., Terides M.D., Titov N. Remote treatment of obsessive-compulsive disorder: a randomized controlled trial. J. Obsessive Compuls. Relat. Disord. 2013;2(4):375–384.
    1. Wootton B.M., Dear B.F., Johnston L., Terides M.D., Titov N. Self-guided internet administered treatment for obsessive-compulsive disorder: results from two open trials. J. Obsessive Compuls. Relat. Disord. 2014;3(2):102–108.
    1. Wootton B.M., Dear B.F., Johnston L., Terides M.D., Titov N. Self-guided internet-delivered cognitive behavior therapy (iCBT) for obsessive–compulsive disorder: 12 month follow-up. Internet Interv. 2015;2(3):243–247.

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