A phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation
Jane L Liesveld, Gordon L Phillips 2nd, Michael Becker, Louis S Constine, Jonathan Friedberg, Jeffrey R Andolina, Laurie A Milner, Jessica DeBolt, Therese Smudzin, Ollivier Hyrien, Connie L Erickson-Miller, Brendan M Johnson, Katie-Louise Dawson, Yuhchyau Chen, Jane L Liesveld, Gordon L Phillips 2nd, Michael Becker, Louis S Constine, Jonathan Friedberg, Jeffrey R Andolina, Laurie A Milner, Jessica DeBolt, Therese Smudzin, Ollivier Hyrien, Connie L Erickson-Miller, Brendan M Johnson, Katie-Louise Dawson, Yuhchyau Chen
Abstract
Stem cell transplantation can be associated with significant periods of thrombocytopenia, necessitating platelet transfusions and contributing to the risk of bleeding. Thrombopoietin receptor agonists have been shown to enhance platelet counts in other clinical settings, and so a phase 1 clinical trial was conducted to assess the safety, pharmacokinetics, and maximum tolerated dose of once-daily eltrombopag in patients undergoing stem cell transplantation with conditioning regimens containing total body irradiation ≥400 cGy. Eltrombopag was examined at dosage levels of 75, 150, 225, and 300 mg given orally once daily for 27 days, starting at 24 to 48 hours post-transplantation. Pharmacokinetic sampling was performed over a 24-hour period after the first dose of eltrombopag, as well as during the second week of treatment (steady-state). Nineteen patients were enrolled, 15 of whom completed protocol treatments. Three patients completed each dose level up to 225 mg, and 6 completed treatment at the highest dose of 300 mg. Four patients were replaced because drug compliance was <75% of planned doses. No dose-limiting toxicities were observed in this heterogeneous post-transplantation patient population. Common adverse events were related to standard stem cell transplantation. One episode of pulmonary embolus occurred 9 days after discontinuation of eltrombopag, and the only other thromboembolic episode was a grade 2 catheter-related clot. We conclude that up to 27 days of once-daily dosing of eltrombopag after stem cell transplantation is well tolerated.
Trial registration: ClinicalTrials.gov NCT00903929.
Keywords: Bone marrow engraftment; Pharmacokinetics; Platelet; Radiation; Thrombocytopenia; Thrombopoietin mimetic.
Copyright © 2013 American Society for Blood and Marrow Transplantation. All rights reserved.
Source: PubMed