Incidence rates and management of urinary tract infections among children in Dutch general practice: results from a nation-wide registration study

Wing-Yee Kwok, Marjolein C E de Kwaadsteniet, Mirjam Harmsen, Lisette W A van Suijlekom-Smit, François G Schellevis, Johannes C van der Wouden, Wing-Yee Kwok, Marjolein C E de Kwaadsteniet, Mirjam Harmsen, Lisette W A van Suijlekom-Smit, François G Schellevis, Johannes C van der Wouden

Abstract

Background: We aimed to investigate incidence rates of urinary tract infections in Dutch general practice and their association with gender, season and urbanisation level, and to analyse prescription and referral in case of urinary tract infections.

Method: During one calendar year, 195 general practitioners in 104 practices in the Netherlands registered all their patient contacts. This study was performed by the Netherlands Institute for Health Services Research (NIVEL) in 2001. Of 82,053 children aged 0 to 18 years, the following variables were collected: number of episodes per patient, number of contacts per episode, month of the year in which the diagnosis of urinary tract infection was made, age, gender, urbanisation level, drug prescription and referral.

Results: The overall incidence rate was 19 episodes per 1000 person years. The incidence rate in girls was 8 times as high as in boys. The incidence rate in smaller cities and rural areas was 2 times as high as in the three largest cities. Throughout the year, incidence rates varied with a decrease in summertime for children at the age of 0 to 12 years. Of the prescriptions, 66% were in accordance with current guidelines, but only 18% of the children who had an indication were actually referred.

Conclusion: This study shows that incidence rates of urinary tract infections are not only related to gender and season, but also to urbanisation. General practitioners in the Netherlands frequently do not follow the clinical guidelines for urinary tract infections, especially with respect to referral.

Figures

Figure 1
Figure 1
Incidence rates of urinary tract infections by age for boys and girls, 95% error bars.
Figure 2
Figure 2
Incidence rates throughout the year by age group, 95% error bars.
Figure 3
Figure 3
Incidence rates according to urbanisation, 95% error bars.

References

    1. van der Voort J, Edwards A, Roberts R, Verrier Jones K. The struggle to diagnose UTI in children under two in primary care. Fam Pract. 1997;14:44–8. doi: 10.1093/fampra/14.1.44.
    1. van de Lisdonk EH, Verstraeten J. Kinderen met urineweginfecties: verwijzen of niet? Huisarts Wet. 2000;42:343–6.
    1. Elo J, Sarna S, Tallgren LG. Seasonal variations in the occurrence of urinary tract infections among children in an urban area in Finland. Ann Clin Res. 1979;11:101–6.
    1. Larcombe J. Urinary tract infection in children. BMJ. 1999;319:1173–5.
    1. Bergström T. Sex differences in childhood urinary tract infection. Arch Dis Childh. 1972;47:227–32.
    1. Nguyen H, Weir M. Urinary tract infection as a possible marker for teenage sex. South Med J. 2002;95:867–9.
    1. Stansfeld JM. Clinical observations relating to incidence and aetiology of urinary-tract infections in children. BMJ. 1966;5488:631–4.
    1. Winberg J, Andersen HJ, Bergström T, Jacobsson B, Larson H, Lincoln K. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand Suppl. 1974;252:1–20.
    1. Mårild S, Jodal U. Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Paediatr. 1998;87:549–52. doi: 10.1080/08035259850158272.
    1. Uhari M, Nuutinen M. Epidemiology of symptomatic infections of the urinary tract in children. BMJ. 1988;297:450–452.
    1. Pead L, Maskell R. Study of urinary tract infection in children in one health district. BMJ. 1994;309:631–4.
    1. Brooks D, Houston IB. Symptomatic urinary tract infection in childhood: presentation during a four-year study in general practice and significance and outcome at seven years. J Roy Coll Gen Pract. 1977;27:678–683.
    1. Dickinson JA. Incidence and outcome of symptomatic urinary tract infection in children. BMJ. 1979;1:1330–2.
    1. Winberg J, Bergström T, Jacobsson B. Morbidity, age and sex distribution, recurrences and renal scarring in symptomatic urinary tract infection in childhood. Kidney Int Suppl. 1975;4:S101–6.
    1. Wennerström M, Hansson S, Jodal U, Stokland E. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr. 2000;136:30–4. doi: 10.1016/S0022-3476(00)90045-3.
    1. Timmermans AE, Baselier PJAM, Winkens PAG, Arets H, Wiersma Tj. Urineweginfecties. NHG-standaard (eerste herziening) Huisarts Wet. 1999;42:613–622.
    1. Hansson S, Bollgren I, Esbjörner E, Jakobsson B, Mårild S. Urinary tract infections in children below two years of age: a quality assurance project in Sweden. Acta Paediatr. 1999;88:270–4. doi: 10.1080/08035259950170015.
    1. Johnson G, Goutam P, Bainbridge M, Brown R. How well do general practitioners manage urinary problems in children? Br J Gen Pract. 1990;40:146–149.
    1. Shortliffe LM, McCue JD. Urinary tract infection at the age extremes: pediatrics and geriatrics. Am J Med. 2002;113:55S–66S. doi: 10.1016/S0002-9343(02)01060-4.
    1. Jakobsson B, Esbjörner E, Hansson S. Minimum incidence and diagnostic rate of first urinary tract infection. Pediatrics. 1999;104:222–6. doi: 10.1542/peds.104.2.222.
    1. Westert GP, Schellevis FG, de Bakker DH, Groenewegen PP, Bensing JM, van der Zee J. Monitoring health inequalities through General Practice: the Second Dutch National Survey of General Practice. Eur J Public Health. 2005;15:59–65. doi: 10.1093/eurpub/cki116.
    1. Otters HBM, van der Wouden JC, Schellevis FG, van Suijlekom-Smit LWA, Koes BW. Changing morbidity patterns in Dutch general practice: 1987–2001. Eur J Gen Pract. 2005;11:17–22.
    1. Lamberts H, Woods M, Hofmans-Okkes I. The international classification of primary care in the European Community. Oxford: Oxford University Press; 1993.
    1. Ki M, Park T, Choi B, Foxman B. The epidemiology of acute pyelonephritis in South Korea, 1997–1999. Am J Epid. 2004;160:985–93. doi: 10.1093/aje/kwh308.
    1. Vorland LH, Carlson K, Aalen O. Antibiotic resistance and small R plasmids among Escherichia coli isolates from outpatient urinary tract infections in northern Norway. Antimicrob Agents Chemother. 1985;27:107–13.

Source: PubMed

3
Sottoscrivi