Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation
Xavier Drouot, Satoru Oshino, Bechir Jarraya, Laurent Besret, Haruhiko Kishima, Philippe Remy, Julien Dauguet, Jean Pascal Lefaucheur, Frédéric Dollé, Françoise Condé, Michel Bottlaender, Marc Peschanski, Yves Kéravel, Philippe Hantraye, Stéphane Palfi, Xavier Drouot, Satoru Oshino, Bechir Jarraya, Laurent Besret, Haruhiko Kishima, Philippe Remy, Julien Dauguet, Jean Pascal Lefaucheur, Frédéric Dollé, Françoise Condé, Michel Bottlaender, Marc Peschanski, Yves Kéravel, Philippe Hantraye, Stéphane Palfi
Abstract
A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.
Source: PubMed