Childhood chronic conditions and health-related quality of life: Findings from a large population-based study

Guannan Bai, Marieke Houben-van Herten, Jeanne M Landgraf, Ida J Korfage, Hein Raat, Guannan Bai, Marieke Houben-van Herten, Jeanne M Landgraf, Ida J Korfage, Hein Raat

Abstract

The objective of this study was to assess the impact of health-related quality of life (HRQOL) across prevalent chronic conditions, individually and comorbid, in school-aged children in the Netherlands. 5301 children aged 4-11 years from the Dutch Health Interview Survey were included. Parents completed questionnaires regarding child and parental characteristics. HRQOL of children was measured using the Child Health Questionnaire Parent Form 28 (CHQ-PF28). Independent-t tests were used to assess differences in the mean scores of the CHQ-PF28 summary scales and profile scales between children with a prevalent chronic condition (excluding or including children with multiple chronic conditions) and children without a chronic condition. Cohen's effect sizes (d) were calculated to assess the clinical significance of difference. The mean age of children was 7.55 (SD 2.30) years; 50.0% were boys. In children without any chronic condition, the mean score of physical summary scale (PhS) was 58.53 (SD 4.28) and mean score of the psychosocial summary scale (PsS) was 53.86 (SD 5.87). Generally, PhS and/or PsS scores in children with only one condition were lower (p<0.05) than for children without chronic conditions. When children with multiple conditions were included, mean scores of CHQ-PF28 summary and profile scales were generally lower than when they were excluded. The present study shows important information regarding the impact of prevalent chronic conditions on HRQOL in a representative population-based sample of school-aged children in the Netherlands. The information could be used for developing a more holistic approach to patient care and a surveillance framework for health promotion.

Conflict of interest statement

Competing Interests: Jeanne M. Landgraf is the Vice President and Chief Scientific Officer for HealthActCHQ which owns the intellectual rights to the CHQ-PF28. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

References

    1. Van Cleave J, Gortmaker SL, Perrin JM. DYnamics of obesity and chronic health conditions among children and youth. JAMA. 2010;303(7):623–30. doi:
    1. Perrin JM, Bloom SR, Gortmaker SL. The increase of childhood chronic conditions in the United States. Jama. 2007;297(24):2755–9. doi:
    1. Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980–2007. Pediatrics. 2009;123 Suppl 3:S131–45.
    1. Robison LM, Sclar DA, Skaer TL, Galin RS. National trends in the prevalence of attention-deficit/hyperactivity disorder and the prescribing of methylphenidate among school-age children: 1990–1995. Clin Pediatr (Phila). 1999;38(4):209–17.
    1. Pastor PN, Reuben CA. Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004–2006. Vital Health Stat 10 2008;(237):1–14.
    1. Clarke SA, Eiser C. The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review. Health Qual Life Outcomes. 2004;2:66 doi:
    1. Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol. 2006;155(1):145–51. doi:
    1. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Qual Life Res. 1996;5(1):35–46.
    1. Merikallio VJ, Mustalahti K, Remes ST, Valovirta EJ, Kaila M. Comparison of quality of life between asthmatic and healthy school children. Pediatric Allergy and Immunology. 2005;16(4):332–40. doi:
    1. Lewis-Jones S. Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract. 2006;60(8):984–92. doi:
    1. Hafkamp-de Groen E, Raat H. Asthma and Health Related Quality of Life in Childhood and Adolescence: INTECH Open Access Publisher; 2012.
    1. Klassen AF, Miller A, Fine S. Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder. Pediatrics. 2004;114(5):e541–7. doi:
    1. Pongwilairat K, Louthrenoo O, Charnsil C, Witoonchart C. Quality of life of children with attention-deficit/hyper activity disorder. J Med Assoc Thai. 2005;88(8):1062–6.
    1. Froisland DH, Graue M, Markestad T, Skrivarhaug T, Wentzel-Larsen T, Dahl-Jorgensen K. Health-related quality of life among Norwegian children and adolescents with type 1 diabetes on intensive insulin treatment: a population-based study. Acta Paediatr. 2013;102(9):889–95. doi:
    1. Petersen S, Hagglof BL, Bergstrom EI. Impaired health-related quality of life in children with recurrent pain. Pediatrics. 2009;124(4):e759–67. doi:
    1. Schipper H, Clinch J, Olweny C. (1996) Quality of Life Studies: Definitions and Conceptual Issues.New York: Lippincott-Raven
    1. Hofman A, Jaddoe VWV, Mackenbach JP, Moll HA, Snijders RFM, Steegers EAP, et al. Growth, development and health from early fetal life until young adulthood: the Generation R Study. Paediatric and perinatal epidemiology. 2004;18(1):61–72.
    1. Ravens-Sieberer U, Wille N, Erhart M, Bettge S, Wittchen H-U, Rothenberger A, et al. Prevalence of mental health problems among children and adolescents in Germany: results of the BELLA study within the National Health Interview and Examination Survey. Eur Child Adolesc Psychiatry. 2008;17(1):22–33.
    1. Waters E, Davis E, Nicolas C, Wake M, Lo SK. The impact of childhood conditions and concurrent morbidities on child health and well-being. Child Care Health Dev. 2008;34(4):418–29. doi:
    1. Lee SL, Cheung YF, Wong HS, Leung TH, Lam TH, Lau YL. Chronic health problems and health-related quality of life in Chinese children and adolescents: a population-based study in Hong Kong. BMJ Open. 2013;3(1).
    1. Sawyer MG, Whaites L, Rey JM, Hazell PL, Graetz BW, Baghurst P. Health-related quality of life of children and adolescents with mental disorders. J Am Acad Child Adolesc Psychiatry. 2002;41(5):530–7. doi:
    1. Sawyer MG, Reynolds KE, Couper JJ, French DJ, Kennedy D, Martin J, et al. Health-related quality of life of children and adolescents with chronic illness—a two year prospective study. Qual Life Res. 2004;13(7):1309–19. doi:
    1. Houben-van Herten M, Bai G, Hafkamp E, Landgraf JM, Raat H. Determinants of health-related quality of life in school-aged children: a general population study in the Netherlands. PLoS One. 2015;10(5):e0125083 doi:
    1. Banning R, Camstra A, Knottnerus P. Sampling theory: Sampling design and estimation methods. The Hague/Heerlen: Statistics Netherlands; 2012.
    1. Statistics Netherlands, CBS (internet). Gezondheidsmetingen kinderen: 2001–2013.
    1. Statistics Netherlands, CBS (internet). Gezondheid, aandoeningen, beperkingen; leeftijd en geslacht, 2010–2013.
    1. Statistics Netherlands, CBS (internet). Health, disorders, limitations; sex and age, 2010–2013..
    1. Raat H, Bonsel GJ, Essink-Bot ML, Landgraf JM, Gemke RJ. Reliability and validity of comprehensive health status measures in children: The Child Health Questionnaire in relation to the Health Utilities Index. J Clin Epidemiol. 2002;55(1):67–76.
    1. Raat H, Botterweck AM, Landgraf JM, Hoogeveen WC, Essink-Bot ML. Reliability and validity of the short form of the child health questionnaire for parents (CHQ-PF28) in large random school based and general population samples. J Epidemiol Community Health. 2005;59(1):75–82. doi:
    1. Raat H, Landgraf JM, Bonsel GJ, Gemke R, Essink-Bot M-L. Reliability and validity of the child health questionnaire-child form (CHQ-CF87) in a Dutch adolescent population. Qual Life Res. 2002;11(6):575–81.
    1. Landgraf JM, Abetz L, Ware JE. Child Health Questionnaire (CHQ): A User's Manual. 1999. Boston, MA: HealthAct.
    1. Questionnaires Health Survey from 2010 to 2013. Stastistics Netherlands, CBS (internet).
    1. Schaart R, Mies Moens B, Westerman S. The Dutch Standard Classification of Education,SOI 2006. Published in 2008. Statistics Netherlands; Voorburg/Heerlen.
    1. Alders M. Classification of the population with a foreign background in the Netherlands.
    1. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd edn. Hillsdale, New Jersey: L. Erlbaum; 1988.
    1. Matthews A, Haas DM, O'Mathuna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2015;(9):CD007575 doi:
    1. Sawyer MG, Spurrier N, Whaites L, Kennedy D, Martin AJ, Baghurst P. The relationship between asthma severity, family functioning and the health-related quality of life of children with asthma. Qual Life Res. 2000;9(10):1105–15.
    1. Mohangoo AD, de Koning HJ, Mangunkusumo RT, Raat H. Health-Related Quality of Life in Adolescents with Wheezing Attacks. Journal of Adolescent Health. 2007;41(5):464–71. doi:
    1. Shaw TE, Currie GP, Koudelka CW, Simpson EL. Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health. Journal of Investigative Dermatology. 2011;131(1):67–73. doi:
    1. Lewis-Jones MS, Finlay AY. The Children's Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132(6):942–9.
    1. Statistics Netherlands, CBS (internet). Slightly more children diagnosed with dyslexia, 2016.
    1. McNulty MA. Dyslexia and the life course. J Learn Disabil. 2003;36(4):363–81. doi:
    1. Danckaerts M, Sonuga-Barke EJ, Banaschewski T, Buitelaar J, Dopfner M, Hollis C, et al. The quality of life of children with attention deficit/hyperactivity disorder: a systematic review. Eur Child Adolesc Psychiatry. 2010;19(2):83–105. doi:
    1. Marques JC, Oliveira JA, Goulardins JB, Nascimento RO, Lima AM, Casella EB. Comparison of child self-reports and parent proxy-reports on quality of life of children with attention deficit hyperactivity disorder. Health Qual Life Outcomes. 2013;11:186 doi:
    1. Bugdayci R, Ozge A, Sasmaz T, Kurt AO, Kaleagasi H, Karakelle A, et al. Prevalence and factors affecting headache in Turkish schoolchildren. Pediatr Int. 2005;47(3):316–22. doi:
    1. Sillanpää M, Piekkala P, Kero P. Prevalence of Headache at Preschool Age in An Unselected Child Population. Cephalalgia. 1991;11(5):239–42. doi:
    1. Padilla-Moledo C, Ruiz JR, Castro-Pinero J. Parental educational level and psychological positive health and health complaints in Spanish children and adolescents. Child Care Health Dev. 2016;42(4):534–43. doi:
    1. Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in childhood migraines: clinical impact and comparison to other chronic illnesses. Pediatrics. 2003;112(1 Pt 1):e1–5.
    1. Varni JW, Limbers CA. The pediatric quality of life inventory: measuring pediatric health-related quality of life from the perspective of children and their parents. Pediatr Clin North Am. 2009;56(4):843–63. doi:
    1. Varni JW, Burwinkle TM, Lane MM. Health-related quality of life measurement in pediatric clinical practice: An appraisal and precept for future research and application. Health and Quality of Life Outcomes. 2005;3:34–. doi:
    1. Mangione-Smith R, Schonlau M, Chan KS, Keesey J, Rosen M, Louis TA, et al. Measuring the effectiveness of a collaborative for quality improvement in pediatric asthma care: does implementing the chronic care model improve processes and outcomes of care? Ambul Pediatr. 2005;5(2):75–82. doi:
    1. Vickers AJ. Statistical considerations for use of composite health-related quality-of-life scores in randomized trials. Qual Life Res. 2004;13(4):717–23. doi:
    1. Eiser C, Morse R. A review of measures of quality of life for children with chronic illness. Arch Dis Child. 2001;84(3):205–11. doi:
    1. Burks ML, Brooks EG, Hill VL, Peters JI, Wood PR. Assessing proxy reports: agreement between children with asthma and their caregivers on quality of life. Ann Allergy Asthma Immunol. 2013;111(1):14–9. doi:
    1. Bastiaansen D, Koot HM, Ferdinand RF, Verhulst FC. Quality of life in children with psychiatric disorders: self-, parent, and clinician report. J Am Acad Child Adolesc Psychiatry. 2004;43(2):221–30. doi:
    1. Davis E, Nicolas C, Waters E, Cook K, Gibbs L, Gosch A, et al. Parent-proxy and child self-reported health-related quality of life: using qualitative methods to explain the discordance. Qual Life Res. 2007;16(5):863–71. doi:
    1. Varni JW, Limbers CA, Burwinkle TM. Parent proxy-report of their children's health-related quality of life: an analysis of 13,878 parents' reliability and validity across age subgroups using the PedsQL 4.0 Generic Core Scales. Health Qual Life Outcomes. 2007;5:2 doi:
    1. Klassen AF, Miller A, Fine S. Agreement between parent and child report of quality of life in children with attention-deficit/hyperactivity disorder. Child Care Health Dev. 2006;32(4):397–406. doi:

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