Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003
Elodie Sellier, Mary Jane Platt, Guro L Andersen, Ingeborg Krägeloh-Mann, Javier De La Cruz, Christine Cans, Surveillance of Cerebral Palsy Network, M Van Bakel, C Arnaud, M Delobel, J Chalmers, V McManus, A Lyons, J Parkes, H Dolk, K Himmelmann, M Pahlman, V Dowding, A Colver, L Pennington, K Horridge, J Kurinczuk, G Surman, P Udall, G Rackauskaite, Mg Torrioli, M Marcelli, S Julsen Hollung, M Bottos, G Gaffney, C Pallas, D Neubauer, M Jekovec-Vrhovšek, D Virella, M Andrada, A Greitane, K Hollody, S Sigurdardottir, I Einarsson, M Honold, K Rostasy, V Mejaski-Bosnjak, Elodie Sellier, Mary Jane Platt, Guro L Andersen, Ingeborg Krägeloh-Mann, Javier De La Cruz, Christine Cans, Surveillance of Cerebral Palsy Network, M Van Bakel, C Arnaud, M Delobel, J Chalmers, V McManus, A Lyons, J Parkes, H Dolk, K Himmelmann, M Pahlman, V Dowding, A Colver, L Pennington, K Horridge, J Kurinczuk, G Surman, P Udall, G Rackauskaite, Mg Torrioli, M Marcelli, S Julsen Hollung, M Bottos, G Gaffney, C Pallas, D Neubauer, M Jekovec-Vrhovšek, D Virella, M Andrada, A Greitane, K Hollody, S Sigurdardottir, I Einarsson, M Honold, K Rostasy, V Mejaski-Bosnjak
Abstract
Aim: To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003.
Method: Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]).
Results: The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births.
Interpretation: The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.
© 2015 Mac Keith Press.
Source: PubMed