Autonomous navigation of a magnetic colonoscope using force sensing and a heuristic search algorithm
Hao-En Huang, Sheng-Yang Yen, Chia-Feng Chu, Fat-Moon Suk, Gi-Shih Lien, Chih-Wen Liu, Hao-En Huang, Sheng-Yang Yen, Chia-Feng Chu, Fat-Moon Suk, Gi-Shih Lien, Chih-Wen Liu
Abstract
This paper presents an autonomous navigation system for cost-effective magnetic-assisted colonoscopy, employing force-based sensors, an actuator, a proportional-integrator controller and a real-time heuristic searching method. The force sensing system uses load cells installed between the robotic arm and external permanent magnets to derive attractive force data as the basis for real-time surgical safety monitoring and tracking information to navigate the disposable magnetic colonoscope. The average tracking accuracy on magnetic field navigator (MFN) platform in x-axis and y-axis are 1.14 ± 0.59 mm and 1.61 ± 0.45 mm, respectively, presented in mean error ± standard deviation. The average detectable radius of the tracking system is 15 cm. Three simulations of path planning algorithms are presented and the learning real-time A* (LRTA*) algorithm with our proposed directional heuristic evaluation design has the best performance. It takes 75 steps to complete the traveling in unknown synthetic colon map. By integrating the force-based sensing technology and LRTA* path planning algorithm, the average time required to complete autonomous navigation of a highly realistic colonoscopy training model on the MFN platform is 15 min 38 s and the intubation rate is 83.33%. All autonomous navigation experiments are completed without intervention by the operator.
Conflict of interest statement
The authors declare no competing interests.
© 2021. The Author(s).
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References
- Zauber AG, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N. Engl. J. Med. 2012;366:687–696. doi: 10.1056/NEJMoa1100370.
- Manser CN, et al. Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: A closed cohort study. Gastrointest. Endosc. 2012;76:110–117. doi: 10.1016/j.gie.2012.02.040.
- Bretthauer M, et al. Population-based colonoscopy screening for colorectal cancer: A randomized clinical trial. JAMA Intern. Med. 2016;176:894–902. doi: 10.1001/jamainternmed.2016.0960.
- Iddan G, Meron G, Glukhovsky A, Swain P. Wireless capsule endoscopy. Nature. 2000;405:417–417. doi: 10.1038/35013140.
- Mylonaki M, Fritscher-Ravens A, Swain P. Wireless capsule endoscopy: A comparison with push enteroscopy in patients with gastroscopy and colonoscopy negative gastrointestinal bleeding. Gut. 2003;52:1122–1126. doi: 10.1136/gut.52.8.1122.
- Ghosh T, Fattah SA, Wahid K. CHOBS: Color histogram of block statistics for automatic bleeding detection in wireless capsule endoscopy video. IEEE J. Transl. Eng. Health Med. 2018 doi: 10.1109/JTEHM.2017.2756034.
- Simi M, Valdastri P, Quaglia C, Menciassi A, Dario P. Design, fabrication, and testing of a capsule with hybrid locomotion for gastrointestinal tract exploration. IEEE/ASME Trans. Mechatron. 2010;15:170–180. doi: 10.1109/TMECH.2010.2041244.
- Mitselos IV, Christodoulou DK, Katsanos KH, Tsianos EV. Role of wireless capsule endoscopy in the follow-up of inflammatory bowel disease. World J. Gastrointest. Endosc. 2015;7:643–651. doi: 10.4253/wjge.v7.i6.643.
- Liu L, Towfighian S, Hila A. A review of locomotion systems for capsule endoscopy. IEEE Rev. Biomed. Eng. 2015;8:138–151. doi: 10.1109/RBME.2015.2451031.
- Trovato G, et al. Development of a colon endoscope robot that adjusts its locomotion through the use of reinforcement learning. Int. J. Comput. Assist. Radiol. Surg. 2010;5:317–325. doi: 10.1007/s11548-010-0481-0.
- Alsunaydih FN, Arefin MS, Redoute J, Yuce MR. A navigation and pressure monitoring system toward autonomous wireless capsule endoscopy. IEEE Sens. J. 2020;20:8098–8107. doi: 10.1109/JSEN.2020.2979513.
- Martin JW, et al. Enabling the future of colonoscopy with intelligent and autonomous magnetic manipulation. Nat. Mach. Intell. 2020;2:595–606. doi: 10.1038/s42256-020-00231-9.
- Kim J-Y, Kwon Y-C, Hong Y-S. Automated alignment of rotating magnetic field for inducing a continuous spiral motion on a capsule endoscope with a twistable thread mechanism. Int. J. Precis. Eng. Manuf. 2012;13:371–377. doi: 10.1007/s12541-012-0047-x.
- Prendergast, J. M., Formosa, G. A., Heckman, C. R. & Rentschler, M. E. in 2018 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) 783–790 (2018).
- Natali CD, Beccani M, Valdastri P. Real-time pose detection for magnetic medical devices. IEEE Trans. Magn. 2013;49:3524–3527. doi: 10.1109/TMAG.2013.2240899.
- Di Natali C, Beccani M, Simaan N, Valdastri P. Jacobian-based iterative method for magnetic localization in robotic capsule endoscopy. IEEE Trans. Robot. 2016;32:327–338. doi: 10.1109/TRO.2016.2522433.
- Taddese AZ, et al. Enhanced real-time pose estimation for closed-loop robotic manipulation of magnetically actuated capsule endoscopes. Int. J. Robot. Res. 2018;37:890–911. doi: 10.1177/0278364918779132.
- Lin J-N, Wang C-B, Yang C-H, Lai C-H, Lin H-H. Risk of infection following colonoscopy and sigmoidoscopy in symptomatic patients. Endoscopy. 2017;49:754–764. doi: 10.1055/s-0043-107777.
- Wang P, et al. Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA. Gut. 2018;67:1626–1636. doi: 10.1136/gutjnl-2017-315308.
- Rutala WA, Kanamori H, Sickbert-Bennett EE, Weber DJ. What's new in reprocessing endoscopes: Are we going to ensure “the needs of the patient come first” by shifting from disinfection to sterilization? Am. J. Infect. Control. 2019;47:A62–A66. doi: 10.1016/j.ajic.2019.01.017.
- Salerno, M., Rizzo, R., Sinibaldi, E. & Menciassi, A. in 2013 IEEE International Conference on Robotics and Automation 5354–5359 (2013).
- Di Natali C, Beccani M, Obstein K, Valdastri P. A wireless platform for in vivo measurement of resistance properties of the gastrointestinal tract. Physiol. Meas. 2014;35:1197. doi: 10.1088/0967-3334/35/7/1197.
- Tugwell J, et al. Electropermanent magnetic anchoring for surgery and endoscopy. IEEE Trans. Biomed. Eng. 2015;62:842–848. doi: 10.1109/TBME.2014.2366032.
- Korman LY, et al. Characterization of forces applied by endoscopists during colonoscopy by using a wireless colonoscopy force monitor. Gastrointest. Endosc. 2010;71:327–334. doi: 10.1016/j.gie.2009.08.029.
- Plooy AM, et al. Construct validation of a physical model colonoscopy simulator. Gastrointest. Endosc. 2012;76:144–150. doi: 10.1016/j.gie.2012.03.246.
- Salerno M, et al. A discrete-time localization method for capsule endoscopy based on on-board magnetic sensing. Meas. Sci. Technol. 2011;23:015701. doi: 10.1088/0957-0233/23/1/015701.
- Ciuti G, Valdastri P, Menciassi A, Dario P. Robotic magnetic steering and locomotion of capsule endoscope for diagnostic and surgical endoluminal procedures. Robotica. 2010;28:199–207. doi: 10.1017/S0263574709990361.
- Lien G, Liu C, Jiang J, Chuang C, Teng M. Magnetic control system targeted for capsule endoscopic operations in the stomach—Design, fabrication, and in vitro and ex vivo evaluations. IEEE Trans. Biomed. Eng. 2012;59:2068–2079. doi: 10.1109/TBME.2012.2198061.
- Mahoney AW, Abbott JJ. Five-degree-of-freedom manipulation of an untethered magnetic device in fluid using a single permanent magnet with application in stomach capsule endoscopy. Int. J. Robot. Res. 2016;35:129–147. doi: 10.1177/0278364914558006.
- Slawinski PR, et al. The first autonomously controlled magnetic flexible endoscope for colon exploration. Gastroenterology. 2018;154:1577. doi: 10.1053/j.gastro.2018.02.037.
- Shah S, Brooker J, Thapar C, Williams C, Saunders B. Patient pain during colonoscopy: An analysis using real-time magnetic endoscope imaging. Endoscopy. 2002;34:435–440. doi: 10.1055/s-2002-31995.
- Bianchi F, et al. Localization strategies for robotic endoscopic capsules: A review. Expert Rev. Med. Dev. 2019;16:381–403. doi: 10.1080/17434440.2019.1608182.
- Shi, Q., Wang, M., Song, S. & Meng, M. Q. in 2019 IEEE Sensors 1–4 (2019).
- Yen SY, et al. A novel method for locating a magnetic-assisted capsule endoscope system. IEEE Trans. Magn. 2020;56:1–6. doi: 10.1109/TMAG.2020.3015409.
- Saliou P, et al. Measures to improve microbial quality surveillance of gastrointestinal endoscopes. Endoscopy. 2016;48:704–710. doi: 10.1055/s-0042-107591.
- Lai SK, Wang Y-Y, Wirtz D, Hanes J. Micro- and macrorheology of mucus. Adv. Drug Deliv. Rev. 2009;61:86–100. doi: 10.1016/j.addr.2008.09.012.
- Lee CY. An algorithm for path connections and its applications. IRE Trans. Electron. Comput. 1961;23:346–365. doi: 10.1109/TEC.1961.5219222.
- Tarjan R. Depth-first search and linear graph algorithms. SIAM J. Comput. 1972;1:146–160. doi: 10.1137/0201010.
- Korf RE. Real-time heuristic search. Artif. Intell. 1990;42:189–211. doi: 10.1016/0004-3702(90)90054-4.
- Sedlack RE. Training to competency in colonoscopy: Assessing and defining competency standards. Gastrointest. Endosc. 2011;74:355–366.e352. doi: 10.1016/j.gie.2011.02.019.
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