Assessing and addressing collider bias in addiction research: the curious case of smoking and COVID-19

Harry Tattan-Birch, John Marsden, Robert West, Suzanne H Gage, Harry Tattan-Birch, John Marsden, Robert West, Suzanne H Gage

No abstract available

Keywords: COVID-19; Causal inference; collider bias; confounding; selection bias; smoking.

Figures

Figure 1
Figure 1
Directed acyclic graph showing causal relationships between exposures, outcomes, and (a) confounders and (b) colliders
Figure 2
Figure 2
Simulated example showing the association between depressive symptoms and impulsivity (a) in the general population and (b) among people who use opioids. Opioid use is a collider, as it can be caused by depressive symptoms or impulsivity. Therefore, selecting a sample of opioid users produces a spurious negative association between depressive symptoms and impulsivity. [Colour figure can be viewed at wileyonlinelibrary.com]

References

    1. Fergusson D. M., Boden J. M., Horwood L. J. Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. Addiction 2006; 101: 556–569.
    1. Greenland S. Quantifying biases in causal models: classical confounding vs collider‐stratification bias. Epidemiology 2003; 14: 300–306.
    1. Greenland S., Pearl J., Robins J. M. Causal diagrams for epidemiologic research. Epidemiology 1999; 10: 37–48.
    1. Griffith G. J., Morris T. T., Tudball M. J., Herbert A., Mancano G., Pike L., et al. Collider bias undermines our understanding of COVID‐19 disease risk and severity. Nat Commun 2020; 11: 5749. 10.1038/s41467-020-19478-2
    1. Simons D, Shahab L, Brown J, Perski O. The association of smoking status with SARS‐CoV‐2 infection, hospitalisation and mortality from COVID‐19: a living rapid evidence review with Bayesian meta‐analyses (version 7). Addiction [internet]. 2020. [cited 2020 Oct 29];add.15276. Available at:
    1. Ward H., Atchison C. J., Whitaker M., Ainslie K. E. C., Elliott J., Okell L. C., et al. Antibody prevalence for SARS‐CoV‐2 in England following first peak of the pandemic: REACT2 study in 100,000 adults. medRxiv 2020; 10.1101/2020.08.12.20173690
    1. Carrat F., le Lamballerie X., Rahib D., Blanché H., Lapidus N., Artaud F., et al. Seroprevalence of SARS‐CoV‐2 among adults in three regions of France following the lockdown and associated risk factors: a multicohort study. medRxiv 2020; 10.1101/2020.09.16.20195693
    1. Heinke D., Rich‐Edwards J. W., Williams P. L., Hernandez‐Diaz S., Anderka M., Fisher S. C., et al. Quantification of selection bias in studies of risk factors for birth defects among livebirths. Paediatr Perinat Epidemiol [internet] 2020; 34: 655 [cited 2020 Oct 29]. Available at:
    1. Lawlor D. A., Tilling K., Smith G. D. Triangulation in aetiological epidemiology. Int J Epidemiol [internet] 2016; 45: 1866–1686 [cited 2020 Oct 29]. Available at:
    1. Gage S. H., Munafò M. R., Davey Smith G. Causal inference in developmental origins of health and disease (DOHaD) research. Annu Rev Psychol [internet] 2016; 67: 567–585 [cited 2020 Oct 29]. Available at:

Source: PubMed

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