Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
Kyle M Kampman, Helen M Pettinati, Kevin G Lynch, Hu Xie, Charles Dackis, David W Oslin, Thorne Sparkman, Tiffany Sharkoski, Charles P O'Brien, Kyle M Kampman, Helen M Pettinati, Kevin G Lynch, Hu Xie, Charles Dackis, David W Oslin, Thorne Sparkman, Tiffany Sharkoski, Charles P O'Brien
Abstract
Objectives: This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence.
Methods: This biphasic clinical trial consisted of a randomized, double-blind, placebo-controlled Detoxification Phase (DP), followed by a 10-week open-label Rehabilitation Phase (RP). Forty alcohol dependent patients were randomly assigned to receive either 1998 mg of acamprosate daily, or matching placebo, during the DP (5-14 days). After completing detoxification, all patients received open label acamprosate (1998 mg daily) in the RP. Outcome measures during the DP included: treatment retention, alcohol withdrawal, alcohol consumption, and oxazepam used. Outcome measures during the RP included: treatment retention and alcohol consumption.
Results: There were no significant outcome differences between acamprosate and placebo-treated patients during the DP. Patients given acamprosate, compared to placebo, during the DP drank more alcohol in the RP.
Conclusions: Starting acamprosate at the beginning of detoxification did not improve DP outcomes. Starting acamprosate after detoxification was completed was associated with better drinking outcomes during subsequent alcohol rehabilitation treatment.
Source: PubMed