Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus
E A Schur, N M Kleinhans, J Goldberg, D Buchwald, M W Schwartz, K Maravilla, E A Schur, N M Kleinhans, J Goldberg, D Buchwald, M W Schwartz, K Maravilla
Abstract
Objective: To develop a non-invasive method of studying brain mechanisms involved in energy homeostasis and appetite regulation in humans by using visual food cues that are relevant to individuals attempting weight loss.
Design: Functional magnetic resonance imaging (fMRI) was used to compare brain activation in regions of interest between groups of food photographs.
Participants: Ten healthy, non-obese women who were not dieting for weight loss.
Measurements: Independent raters viewed food photographs and evaluated whether the foods depicted should be eaten by individuals attempting a calorically-restricted diet. Based on their responses, we categorized photographs into 'non-fattening' and 'fattening' food groups, the latter characterized by high-caloric content and usually also high-fat or high-sugar content. Blood oxygen level-dependent (BOLD) response was measured by fMRI while participants viewed photographs of 'fattening' food, 'non-fattening' food, and non-food objects.
Results: Viewing photographs of fattening food compared with non-food objects resulted in significantly greater activation in the brainstem; hypothalamus; left amygdala; left dorsolateral prefrontal cortex; left orbitofrontal cortex; right insular cortex; bilateral striatum, including the nucleus accumbens, caudate nucleus, and putamen; bilateral thalamus; and occipital lobe. By comparison, only the occipital region had greater activation by non-fattening food than by object photographs. Combining responses to all food types resulted in attenuation of activation in the brainstem, hypothalamus, and striatum.
Conclusion: These findings suggest that, in non-obese women, neural circuits engaged in energy homeostasis and reward processing are selectively attuned to representations of high-calorie foods that are perceived as fattening. Studies to investigate hormonal action or manipulation of energy balance may benefit from fMRI protocols that contrast energy-rich food stimuli with non-food or low-calorie food stimuli.
Figures
![Figure 1. Patterns of brain activation differ…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2697279/bin/nihms103349f1.jpg)
Figure 2. A comparison of brain activation…
Figure 2. A comparison of brain activation in regions of interest based on choice of…
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- Research Support, N.I.H., Extramural
- Adult
- Appetite Regulation / physiology*
- Cerebral Cortex / physiology*
- Choice Behavior / physiology*
- Cues
- Female
- Food
- Food Preferences / psychology*
- Humans
- Hypothalamus / physiology*
- Magnetic Resonance Imaging
- Middle Aged
- Photic Stimulation / methods
- Photography
- Reward
- Young Adult
- Full Text Sources
- Medical
![Figure 2. A comparison of brain activation…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2697279/bin/nihms103349f2.jpg)
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Source: PubMed