Health-Related Quality-of-Life after Laparoscopic Gastric Bypass Surgery with or Without Closure of the Mesenteric Defects: a Post-hoc Analysis of Data from a Randomized Clinical Trial

Erik Stenberg, Eva Szabo, Johan Ottosson, Anders Thorell, Ingmar Näslund, Erik Stenberg, Eva Szabo, Johan Ottosson, Anders Thorell, Ingmar Näslund

Abstract

Background: Mesenteric defect closure in laparoscopic gastric bypass surgery has been reported to reduce the risk for small bowel obstruction. Little is known, however, about the effect of mesenteric defect closure on patient-reported outcome. The aim of the present study was to see if mesenteric defect closure affects health-related quality-of-life (HRQoL) after laparoscopic gastric bypass.

Methods: Patients operated at 12 centers for bariatric surgery participated in this randomized two-arm parallel study. During the operation, patients were randomized to closure of the mesenteric defects or non-closure. This study was a post-hoc analysis comparing HRQoL of the two groups before surgery, at 1 and 2 years after the operation. HRQoL was estimated using the short form 36 (SF-36-RAND) and the obesity problems (OP) scale.

Results: Between May 1, 2010, and November 14, 2011, 2507 patients were included in the study and randomly assigned to mesenteric defect closure (n = 1259) or non-closure (n = 1248). In total, 1619 patients (64.6%) reported on their HRQoL at the 2-year follow-up. Mesenteric defect closure was associated with slightly higher rating of social functioning (87 ± 22.1 vs. 85 ± 24.2, p = 0.047) and role emotional (85 ± 31.5 vs. 82 ± 35.0, p = 0.027). No difference was seen on the OP scale (open defects 22 ± 24.8 vs. closed defects 20 ± 23.8, p = 0.125).

Conclusion: When comparing mesenteric defect closure with non-closure, there is no clinically relevant difference in HRQoL after laparoscopic gastric bypass surgery.

Trial registration: ClinicalTrials.gov NCT01137201.

Keywords: Bariatric surgery; Health-related quality-of-life; Internal hernia; Laparoscopic gastric bypass; Randomized clinical trial; Small bowel obstruction.

Conflict of interest statement

Conflict of Interest

Ingmar Näslund has received consultant fees from Baricol Bariatrics AB, Sweden. Erik Stenberg, Eva Szabo, Johan Ottosson, and Anders Thorell declare that they have no conflict of interest.

Ethical Approval

The study was conducted in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments and with approval of the ethical research committee of the Uppsala-Örebro region. Trial registration available at Funding

This work was supported by grants from the Örebro County Council, Örebro University, and the Erling-Persson Family Foundation.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
OP score for the two study groups at baseline, 1 and 2 years after the operation

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