Osteoarthritis increases the risk of dementia: a nationwide cohort study in Taiwan

Shih-Wei Huang, Wei-Te Wang, Lin-Chung Chou, Chun-De Liao, Tsan-Hon Liou, Hui-Wen Lin, Shih-Wei Huang, Wei-Te Wang, Lin-Chung Chou, Chun-De Liao, Tsan-Hon Liou, Hui-Wen Lin

Abstract

Osteoarthritis (OA) and dementia are prevalent causes of disability in geriatric patients. To date, information on the temporal correlation between these progressive diseases and the risk of dementia in patients with OA is limited. This retrospective population-based 4-year cohort study investigated the risk of dementia in patients with OA. We performed a case-control matched analysis by using the Taiwan Longitudinal Health Insurance Database 2005. Patients were selected on the basis of International Classification of Diseases, Ninth Revision, Clinical Modification codes for OA between January 1, 2004 and December 31, 2007. The prevalence and the adjusted hazard ratio (HR) of dementia in patients with and without OA were estimated. The OA cohort comprised 35,149 patients and the non-OA cohort (comparison cohort) comprised 70,298 patients (1:2). The incidence of dementia was 21.7 per 10,000 person-years in the OA cohort and 14.7 per 10,000 person-years in the non-OA cohort. The HR for dementia during the follow-up period was 1.33 (95% confidence interval [CI], 1.17-1.50, P < 0.001) for patients with OA. The adjusted HR for dementia was 1.25 (95% CI, 1.10-1.43, P < 0.001) for patients with OA. The results of this study indicated that OA is an independent risk factor for dementia.

Figures

Figure 1
Figure 1
Kaplan–Meier hazard curve for dementia in osteoarthritis (OA) patients and the controls over a 4-year follow-up period.

References

    1. Guccione A. A. et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. American journal of public health. 84, 351–358 (1994).
    1. Vos T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380, 2163–2196, doi:10.1016/S0140-6736(12)61729-2 (2012).
    1. Nuesch E. et al. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. Bmj. 342, d1165, 10.1136/bmj.d1165 (2011).
    1. Rowe J. W. Health care of the elderly. The New England journal of medicine. 312, 827–835, 10.1056/NEJM198503283121305 (1985).
    1. Europe A. World Alzheimer Report. London: Alzheimer’s Disease International (2009).
    1. Schaller S., Mauskopf J., Kriza C., Wahlster P. & Kolominsky-Rabas P. L. The main cost drivers in dementia: a systematic review. International journal of geriatric psychiatry, 10.1002/gps.4198 (2014).
    1. Feldman H. et al. The disability assessment for dementia scale: a 12-month study of functional ability in mild to moderate severity Alzheimer disease. Alzheimer disease and associated disorders. 15, 89–95 (2001).
    1. Kyrkanides S. et al. Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice. Journal of neuroinflammation. 8, 112, 10.1186/1742-2094-8-112 (2011).
    1. Breslow N. E. & Clayton D. G. Approximate inference in generalized linear mixed models. Journal of the American Statistical Association. 88, 9–25 (1993).
    1. Ripatti S. & Palmgren J. Estimation of Multivariate Frailty Models Using Penalized Partial Likelihood. Biometrics. 56, 1016–1022 (2000).
    1. Therneau T. M. & Grambsch P. M. Modeling Survival Data : Extending the Cox Model New York: Springer-Verlag. (2000).
    1. Hawker G. A. et al. A longitudinal study to explain the pain-depression link in older adults with osteoarthritis. Arthritis care & research. 63, 1382–1390, 10.1002/acr.20298 (2011).
    1. Sale J. E., Gignac M. & Hawker, G. How “bad” does the pain have to be ? A qualitative study examining adherence to pain medication in older adults with osteoarthritis. Arthritis and rheumatism. 55, 272–278, 10.1002/art.21853 (2006).
    1. Kodama S. et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. Jama. 301, 2024–2035, 10.1001/jama.2009.681 (2009).
    1. Gulati M. et al. The prognostic value of a nomogram for exercise capacity in women. The New England journal of medicine. 353, 468–475, 10.1056/NEJMoa044154 (2005).
    1. Bowen M. E. A prospective examination of the relationship between physical activity and dementia risk in later life. American journal of health promotion : AJHP. 26, 333–340, 10.4278/ajhp.110311-QUAN-115 (2012).
    1. Sofi F. et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. Journal of internal medicine. 269, 107–117, 10.1111/j.1365-2796.2010.02281.x (2011).
    1. Ahlskog J. E., Geda Y. E., Graff-Radford N. R. & Petersen R. C. Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clinic proceedings. 86, 876–884, 10.4065/mcp.2011.0252 (2011).
    1. Scarmeas N. et al. Physical activity, diet, and risk of Alzheimer disease. Jama. 302, 627–637, 10.1001/jama.2009.1144 (2009).
    1. Buchman A. S. et al. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 78, 1323–1329, 10.1212/WNL.0b013e3182535d35 (2012).
    1. Lau E. C. et al. Factors associated with osteoarthritis of the hip and knee in Hong Kong Chinese: obesity, joint injury, and occupational activities. American journal of epidemiology. 152, 855–862 (2000).
    1. Tolppanen A. M. et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. Journal of Alzheimer’s disease : JAD. 38, 201–209, 10.3233/JAD-130698 (2014).
    1. Aarsland D., Sardahaee F. S., Anderssen S., Ballard C. & Alzheimer’s Society Systematic Review, g. Is physical activity a potential preventive factor for vascular dementia ? A systematic review. Aging & mental health. 14, 386–395, 10.1080/13607860903586136 (2010).
    1. Rovio S. et al. The effect of midlife physical activity on structural brain changes in the elderly. Neurobiology of aging. 31, 1927–1936, 10.1016/j.neurobiolaging.2008.10.007 (2010).
    1. Erickson K. I. et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America. 108, 3017–3022, 10.1073/pnas.1015950108 (2011).
    1. Martel-Pelletier J., Alaaeddine N. & Pelletier J. P. Cytokines and their role in the pathophysiology of osteoarthritis. Frontiers in bioscience : a journal and virtual library. 4, D694–703 (1999).
    1. Goldring M. B., Suen L. F., Yamin R. & Lai W. F. Regulation of Collagen Gene Expression by Prostaglandins and Interleukin-1beta in Cultured Chondrocytes and Fibroblasts. American journal of therapeutics. 3, 9–16 (1996).
    1. Westacott C. I. & Sharif M. Cytokines in osteoarthritis: mediators or markers of joint destruction ? . Seminars in arthritis and rheumatism. 25, 254–272 (1996).
    1. Engelhart M. J. et al. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Archives of neurology. 61, 668–672, 10.1001/archneur.61.5.668 (2004).
    1. Tan Z. S. et al. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 68, 1902–1908, 10.1212/01.wnl.0000263217.36439.da (2007).
    1. Holmes C. et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 73, 768–774, 10.1212/WNL.0b013e3181b6bb95 (2009).
    1. Ownby R. L., Crocco E., Acevedo A., John V. & Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Archives of general psychiatry. 63, 530–538, 10.1001/archpsyc.63.5.530 (2006).
    1. Murphy L. B., Sacks J. J., Brady T. J., Hootman J. M. & Chapman D. P. Anxiety and depression among US adults with arthritis: prevalence and correlates. Arthritis care & research. 64, 968–976, 10.1002/acr.21685 (2012).
    1. Rosemann T. et al. Predictors of depression in a sample of 1,021 primary care patients with osteoarthritis. Arthritis and rheumatism. 57, 415–422, 10.1002/art.22624 (2007).
    1. Clement N. D., MacDonald D. & Burnett R. Primary total knee replacement in patients with mental disability improves their mental health and knee function: a prospective study. The bone & joint journal. 95-B, 360–366, 10.1302/0301-620X.95B3.29563 (2013).

Source: PubMed

Sponsor e collaboratori

Condizioni mediche

Interventi farmacologici

3
Sottoscrivi