Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease

Kofi A Anie, Hannah Grocott, Lauren White, Mendwas Dzingina, Gabriel Rogers, Gavin Cho, Kofi A Anie, Hannah Grocott, Lauren White, Mendwas Dzingina, Gabriel Rogers, Gavin Cho

Abstract

Introduction: Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.

Objectives: To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.

Design: Longitudinal study across three time-points.

Setting: Secondary care, single specialist sickle cell centre.

Participants: 510 adult patients with SCD admitted to hospital daycare or inpatient units.

Outcome measures: Self-assessments of pain, mood and health-related quality of life with health utility (measured on the EQ-5D) on admission, before discharge and at 1-week postdischarge.

Results: Mood, general health and quality of life showed significant steady improvements with reduction of pain in patients with SCD on admission to hospital, before discharge and at 1-week follow-up (p<0.01). Health utility scores derived from the EQ-5D showed a negative association with pain in regression analysis over the three time-points.

Conclusion: Examining health-related quality of life and health utility in relation to pain during hospital admissions is valuable in terms of targeting appropriate psychological interventions within the context of a multidisciplinary approach to managing sickle cell pain. This has implications for healthcare costs.

Conflict of interest statement

Competing interests: KAA was a co-opted expert to the NICE Guideline Development Group for the Sickle Cell Acute Painful Episode. The authors declare that there is no support from any organisation for the submitted work, no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years and no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1
Pain and health-related quality of life assessment form.
Figure 2
Figure 2
Pain, mood and general health status scores of adult patients with sickle cell disease (general health scores are scaled down from 100 to 10).
Figure 3
Figure 3
Health utility indices of adult patients with sickle cell disease.
Figure 4
Figure 4
Relationship between sickle cell pain and health utility. VAS, Visual Analogue Scales.

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Source: PubMed

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