Cetuximab treatment in a patient with metastatic colorectal cancer and psoriasis

B Neyns, V Meert, F Vandenbroucke, B Neyns, V Meert, F Vandenbroucke

Abstract

Cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor, has activity against colorectal cancer. Treatment is associated with skin toxicity, and the safety of cetuximab in patients with psoriasis is unknown. We report the case of a male patient with stage iv colorectal cancer (crc) and a life-long history of extensive psoriasis. This patient experienced a durable remission of his crc and major improvement of his psoriasis during single-agent treatment with cetuximab. We conclude that, despite its known skin toxicity, cetuximab treatment can be offered to colorectal patients suffering from psoriasis.

Keywords: Cetuximab; colorectal cancer; psoriasis; skin toxicity.

Figures

FIGURE 1
FIGURE 1
Tumour response and resolution of psoriasis in a patient with metastatic colorectal cancer (crc) treated with cetuximab monotherapy. An 80-year-old man was treated with cetuximab third-line for metastatic crc. His psoriasis on lower limbs, elbows, forearms, trunk, and face diminished in intensity after 6 weeks of treatment. This improvement was accompanied by almost complete regression of liver metastases. (A,C) February 2007. (B,D) May 2007.

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Source: PubMed

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