Oral protein calorie supplementation for children with chronic disease
Damian K Francis, Joanne Smith, Tawab Saljuqi, Ruth M Watling, Damian K Francis, Joanne Smith, Tawab Saljuqi, Ruth M Watling
Abstract
Background: Poor growth and nutritional status are common in children with chronic diseases. Oral protein calorie supplements are used to improve nutritional status in these children. These expensive products may be associated with some adverse effects, e.g. the development of inappropriate eating behaviour patterns. This is a new update of a Cochrane review last updated in 2009.
Objectives: To examine evidence that in children with chronic disease, oral protein calorie supplements alter daily nutrient intake, nutritional indices, survival and quality of life and are associated with adverse effects, e.g. diarrhoea, vomiting, reduced appetite, glucose intolerance, bloating and eating behaviour problems.
Search methods: Trials of oral protein calorie supplements in children with chronic diseases were identified through comprehensive electronic database searches, handsearching relevant journals and abstract books of conference proceedings. Companies marketing these products were also contacted.Most recent search of the Group's Trials Register: 24 February 2015.
Selection criteria: Randomised or quasi-randomised controlled trials comparing oral protein calorie supplements for at least one month to increase calorie intake with existing conventional therapy (including advice on improving nutritional intake from food or no specific intervention) in children with chronic disease.
Data collection and analysis: We independently assessed the outcomes: indices of nutrition and growth; anthropometric measures of body composition; calorie and nutrient intake (total from oral protein calorie supplements and food); eating behaviour; compliance; quality of life; specific adverse effects; disease severity scores; and mortality; we also assessed the risk of bias in the included trials.
Main results: Four studies (187 children) met the inclusion criteria. Three studies were carried out in children with cystic fibrosis and one study included children with paediatric malignant disease. Overall there was a low risk of bias for blinding and incomplete outcome data.Two studies had a high risk of bias for allocation concealment. Few statistical differences were found in the outcomes we assessed between treatment and control groups, except change in total energy intake at six and 12 months, mean difference 304.86 kcal per day (95% confidence interval 5.62 to 604.10) and mean difference 265.70 kcal per day (95% confidence interval 42.94 to 485.46), respectively. However, these were based on the analysis of just 58 children in only one study. Only two chronic diseases were included in these analyses, cystic fibrosis and paediatric malignant disease. No other studies were identified which assessed the effectiveness of oral protein calorie supplements in children with other chronic diseases.
Authors' conclusions: Oral protein calorie supplements are widely used to improve the nutritional status of children with a number of chronic diseases. We identified a small number of studies assessing these products in children with cystic fibrosis and paediatric malignant disease, but were unable to draw any conclusions based on the limited data extracted. We recommend a series of large, randomised controlled trials be undertaken investigating the use of these products in children with different chronic diseases. Until further data are available, we suggest these products are used with caution.
Conflict of interest statement
Original review and updates to 2009Two of the authors are dietitians (VP, RW) who have received travel expenses to attend conferences from the manufacturers of oral protein calorie supplements.
All three of the authors of this review were involved in the CALICO trial (Poustie 2006).
Subsequent updatesRuth Watling is a dietitian who has received sponsorship to attend meetings and conferences and honorarium to present lectures at conferences and study days from companies who produce oral protein calorie supplements. She declares that this does not influence the use of such products in her clinical practice where the clinical condition, age and nutritional status of the child in conjunction with the scientific evidence is paramount to her decision making. Ruth Watling was also involved in the CALICO trial (Poustie 2006).
The remaining authors declare no conflict of interest.
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References
References to studies included in this review Bayram 2009 {published data only}
- Bayram I, Erbey F, Celik N, Nelson J L, Tanyeli A. The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy‐related weight loss in children. Pediatric Blood & Cancer 2009;52(5):571‐4.
- Hanning RM, Blimkie CJ, Bar‐Or O, Lands LC, Moss LA, Wilson WM. Relationships among nutritional status and skeletal and respiratory muscle function in cystic fibrosis: does early dietary supplementation make a difference?. American Journal of Clinical Nutrition 1993;57(4):580‐7.
- Lands LC, Heigenhauser GJF, Bar‐Or O, Blimkie C, Hanning R, Wilson WM, et al. The effect of early nutritional supplementation on respiratory function in cystic fibrosis (CF). American Review of Respiratory Disease 1992;145:115.
- Kalnins D, Corey M, Ellis L, Pencharz PB, Tullis E, Durie PR. Failure of conventional strategies to improve nutritional status in malnourished adolescents and adults with cystic fibrosis. Journal of Pediatrics 2005;147(3):399‐401.
- Kalnins D, Durie PR. Oral supplements vs normal food intake in children and adults. Israel Journal of Medical Science 1996;32:S120‐1.
- Kalnins D, Durie PR, Corey M, Ellis L, Pencharz P, Tullis E. Are oral dietary supplements effective in the nutritional management of adolescents and adults with cystic fibrosis. Pediatric Pulmonology 1996;Suppl 11:314‐5.
- Poustie VJ, Russell JE, Watling RM, Ashby D, Smyth RL. Baseline characteristics of children participating in the CALICO trial of oral calorie supplements for cystic fibrosis. Journal of cystic fibrosis 2004;3(Suppl 1):S79.
- Poustie VJ, Russell JE, Watling RM, Ashby D, Smyth RL. Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trial. BMJ 2006;332(7542):632‐6.
- Poustie VJ, Russell JE, Watling RM, Ashby D, Smyth RL. Recruitment of children to the CALICO trial of oral calorie supplements for cystic fibrosis. Journal of cystic fibrosis 2004;3(Suppl 1):S76.
- Poustie VJ, Russell JE, Watling RM, Ashby D, Smyth RS. The CALICO multi‐centre randomised controlled trial of oral calorie supplements for children with cystic fibrosis [abstract]. Pediatric Pulmonology 2004;38(Suppl 27):333.
- Abdulhamid I, Beck FW, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatric Pulmonology 2008;43(3):281‐7.
- Abdulhamid I, Millard S, Beck F, Chen X, Wagnen C, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis [abstract]. Pediatric Pulmonology 2005;40(Suppl 28):348.
- Agtmaal VE, Egger RJ, Bloem MW. Effects of nutritional supplementation on the protein composition of tear fluid of marginally nourished preschool children. Documenta Ophthalmologica 1990;76:178.
- Akobeng AK, Miller V, Stanton J, Elbadri AM, Thomas AG. Double‐blind randomized controlled trial of glutamine‐enriched polymeric diet in the treatment of active Crohn's disease. Journal of Pediatric Gastroenterology and Nutrition 2000;30(1):78‐84.
- Akobeng AK, Richmond K, Miller V, Thomas AG. Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease. Clinical Nutrition 2007;26(1):51‐6.
- Alexander JW, MacMillan BG, Stinnett JD, Ogle CK, Bozian RC, Fischer JE, et al. Beneficial effects of aggressive protein feeding in severely burned children. Annals of Surgery 1980;192(4):505‐17.
- Arora NK, Anand NK, Bhan MK, Jailkhani B, Aggarwal A, Meenu R, et al. Nutrient absorption from a fat‐enriched diet in young malnourished children: a randomised controlled trial. Acta Paediatrica 1998;87(2):143‐8.
- Attard‐Montalto SP, Hadley J, Kingston JE, Eden OB, Saha V. Ongoing assessment of nutritional status in children with malignant disease. Pediatric Hematology and Oncology 1998;15(5):393‐403.
- Badaloo A, Boyne M, Reid M, Persaud C, Forrester T, Millward DJ, et al. Dietary protein, growth and urea kinetics in severely malnourished children and during recovery. Journal of Nutrition 1999;129(5):969‐79.
- Ball C, Punchard NA, Howell S, Thompson RPH. Essential fatty acid supplementation in children with cystic fibrosis [abstract]. Proceedings of the 16th Annual Meeting of the European Working Group for Cystic Fibrosis. 1989:84. [MEDLINE: ]
- Barbosa E, Moreira EA, Goes JE, Faintuch J. Pilot study with a glutamine‐supplemented enteral formula in critically ill infants. Revista do Hospital das Clinicas 1999;54(1):21‐4.
- Bengoa JM, Griessen M, Kahn JM, Vadas L, Infante F, LE. Glycemic response and hydrogen production in blenderized and polymeric enteral nutrition formulas [abstract]. Clinical Nutrition 1985;4(Spec Suppl):112.
- Bennett VA, Morales E, Gonzalez J, Peerson JM, Lopez DR, Brown KH. Effects of dietary viscosity and energy density on total daily energy consumption by young Peruvian children. American Journal of Clinical Nutrition 1999;70(2):285‐91. [MEDLINE: ]
- Bernstein ML, Baruchel S, Devine S, Markoglou N, Wainer IW, Williams M, et al. Phase I and pharmacokinetic study of CI‐980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study. Journal of the American Society of Pediatric Hematology/Oncology 1999;21(6):494‐500.
- Berry HK, Kellogg FW, Hunt MM, Ingberg RL, Gutjahr C. Dietary supplement and nutrition in children with cystic fibrosis. American Journal of Diseases of Childhood 1975;129:165‐71. [MEDLINE: ]
- Borrelli O, Cordischi L, Cirulli M, Paganelli M, Labalestra V, Uccini S, Russo PM, Cucchiara S. Polymeric diet alone versus corticosteroids in the treatment of active Crohn's disease: a randomised controlled open‐label trial. Clinical Gastroenterology & Hepatology 2006;4(6):744‐53.
- Botrán M, López‐Herce J, Mencía S, Urbano J, Solana M J, García A. Enteral nutrition in the critically ill child: comparison of standard and protein‐enriched diets. The Journal of Pediatrics 2011:27‐32.e1.
- Braga M, Gianotti L, Radaelli G, Vignali A, Mari G, Gentilini O, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double‐blind phase 3 trial. Archives of Surgery 1999;134(4):428‐33. [MEDLINE: ]
- Bruzzese E, Raia V, Spagnuolo MI, Volpicelli M, Marco G, Maiuri L, et al. Effect of Lactobacillus GG supplementation on pulmonary exacerbations in patients with cystic fibrosis: a pilot study. Clinical Nutrition 2007;26(3):322‐8.
- Cassidy JT. Medical management of children with juvenile rheumatoid arthritis. Drugs 1999;58(5):831‐50.
- Chan JC, Greifer I, Boineau FG, Mendoza SA, McEnery PT, Strife CF, et al. Rational of the growth failure in children with renal diseases study. Journal of Pediatrics 1990; Vol. 116:S11‐6. [MEDLINE: ]
- Massie MD, Strife CF, Foreman JW, Chan JC. Quality control of the nutritional component of the growth failure in children with renal diseases study. Journal of Pediatrics 1990;116(2):S40‐5.
- Chawla P, Puri R. An evaluation of the pre‐school supplementary feeding programme in Chandigarh. Indian Pediatrics 1983;20(5):357‐61. [MEDLINE: ]
- Coghlin‐Dickson TM, Wong RM, Offrin RS, Shizuru JA, Johnston LJ, Hu WW, et al. Effect of oral glutamine supplementation during bone marrow transplantation. Journal of Parenteral and Enteral Nutrition 2000;24(2):61‐6.
- Dartois AM, Terzi F, Kleinknecht C, Niaudet P. Comparison of two protein diets in infants with chronic renal failure. Journal of Renal Nutrition 1995;5:52‐61.
- Dhanraj P, Chacko A, Mammen M, Bharathi R. Hospital‐made diet versus commercial supplement in postburn nutritional support. Burns 1997;23(6):512‐4. [MEDLINE: ]
- Dykman KD, Dykman RA. Effect of nutritional supplements on attentional‐deficit hyperactivity disorder. Integrative Physiological and Behavioral Science : the official journal of the Pavlovian Society 1998;33(1):49‐60.
- Dziechciarz P, Horvath A, Shamir R, Szajewska H. Meta‐analysis: enteral nutrition in active Crohn's disease in children. Alimentary Pharmacology & Theraputics 2007;26(6):795‐806.
- Edefonti A, Picca M, Damiani B, Loi S, Ghio L, Giani M, et al. Dietary prescription based on estimated nitrogen balance during peritoneal dialysis. Pediatric Nephrology 1999;13(3):253‐8. [MEDLINE: ]
- Elhasid R, Laor A, Lischinsky S, Postovsky S, Weyl BA. Nutritional status of children with solid tumors. Cancer 1999;86(1):119‐25. [MEDLINE: ]
- Massie MD, Strife CF, Foreman JW, Chan JC. Quality control of the nutritional component of the growth failure in children with renal diseases study. Journal of Pediatrics 1990; Vol. 116, issue 2:S40‐5. [MEDLINE: ]
- English RM, Badcock JC, Giay T, Ngu T, Waters AM, Bennett SA. Effect of nutrition improvement project on morbidity from infectious diseases in preschool children in Vietnam: comparison with control commune. BMJ 1997;315(7116):1122‐5.
- Fauveau C, Siddiqui M, Briend A, Silimperi DR, Begum N, Fauveau V. Limited impact of a targeted food supplementation programme in Bangladeshi urban slum children. Annals of Tropical Paediatrics 1992; Vol. 12, issue 1:41‐6. [MEDLINE: ]
- Fell JM, Paintin M, Arnaud BF, Beattie RM, Hollis A, Kitching P, et al. Mucosal healing and a fall in mucosal pro‐inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease. Alimentary Pharmacology & Therapeutics 2000;14(3):281‐9.
- Gianotti L, Braga M, Fortis C, Soldini L, Vignali A, Colombo S, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine‐, omega‐3 fatty acid‐, and RNA‐enriched enteral diet: effect on host response and nutritional status. Journal of Parenteral and Enteral Nutrition 1999;23(6):314‐20.
- Gibson RA, Makrides M, Neumann MA, SK. Dietary long chain polyunsaturated fatty acids (LCPUFA) do not influence growth of term infants: a randomised clinical trial [abstract]. Proceedings of the Nutrition Society of Australia. 1998; Vol. 22:95.
- Gottrand F, Hankard R, Michaud L, Ategbo S, Dabadie A, Druon D, et al. Effect of glucose to fat ratio on energy substrate disposal in children with cystic fibrosis fed enterally. Clinical Nutrition 1999;18(5):297‐300.
- Granados EA. Which treatment should children with recurrent urinary infections, without anatomical anomalies, receive?. Archivos Espanoles de Urologia 1998;51(4):354‐7.
- Haffejee A, Angorn IB, Baker LW. Nutritional support in high‐output fistulas of the alimentary tract. South African Medical Journal 1980;57(7):227‐31.
- Hanafy MM, Aref MK, Seddik Y, Zein MS, el‐Kashlan KM. Effect of supplementary feeding on the nutritional status of preschool children. Journal of Tropical Medicine and Hygeine 1967;70(10):238‐42. [MEDLINE: ]
- Hansen GV, Nielson L, Kluger E, Thysen M, Emmertsen H, Stengaard‐Pedersen K, et al. Nutritional status of Danish rheumatoid arthritis patients and effects of a diet adjusted in energy intake, fish‐meal and antioxidants. Scandinavian Journal of Rheumatology 1996;25(5):325‐30. [MEDLINE: ]
- Heikens GT, Schofield WN, Dawson S, and‐Grantham MS. The Kingston project. I. Growth of malnourished children during rehabilitation in the community, given a high energy supplement. European Journal of Clinical Nutrition 1989;43(3):145‐60.
- Hopman GD, Pena EG, Broekhof WJ. Nutritional support for children who undergo bone marrow transplantation: enteral or parenteral?. Tijdschrift voor Kindergeneeskunde 1997;65:39.
- Hopman E, Pena E, Broekhof S, Cessie S, Hullu A, Weel M, et al. Nutritional support in children undergoing bone marrow transplantation: enteral or parenteral? [abstract]. European Journal of Gastroenterology & Hepatology 1998;10:A.
- Caulfield LE, Himes JH, Rivera JA. Nutritional supplementation during early childhood and bone mineralization during adolescence. Journal of Nutrition 1995;125(Suppl 4):1104S‐10S. [MEDLINE: ]
- Haas JD, Martinez EJ, Murdoch S, Conlisk E, Rivera JA, Martorell R. Nutritional supplementation during the preschool years and physical work capacity in adolescent and young adult Guatemalans. Journal of Nutrition 1995;125(Suppl 4):1078S‐89S. [MEDLINE: ]
- Habicht JP, Martorell R, Rivera JA. Nutritional impact of supplementation in the INCAP longitudinal study: analytic strategies and interences. Journal of Nutrition 1995;125(Suppl 4):1042S‐50S. [MEDLINE: ]
- Martorell R. Results and implications of the INCAP follow‐up study. Journal of Nutrition 1995;125(Suppl 4):1127S‐38S.
- Martorell R, Habicht JP, Rivera JA. History and design of the INCAP longitudinal study (1969‐77) and its follow‐up (1988‐89). Journal of Nutrition 1995;125(Suppl 4):1027S‐41S.
- Pickett KE, Haas JD, Rivera JA, Martorell R. Early nutritional supplementation and skeletal maturation in Guatemalan adolescents. Journal of Nutrition 1995;125(Suppl 4):1097S‐103S. [MEDLINE: ]
- Rivera JA, Habicht JP. The recovery of Guatemalan children with mild to moderate wasting: factors enhancing the impact of supplementary feeding. American Journal of Public Health 1996;86(10):1430‐4.
- Rivera JA, Habicht JP, Robson DS. Effect of supplementary feeding on recovery from mild to moderate wasting in preschool children. American Journal of Clinical Nutrition 1991;54(1):62‐8.
- Rivera JA, Martorell R, Ruel MT, Habicht JP, Haas JD. Nutritional supplementation during the preschool years influences body size and composition of Guatemalan adolescents. Journal of Nutrition 1995;125(Suppl 4):1068S‐77S.
- Schroeder DG, Martorell R, Rivera JA, Ruel MT. Age differences in the impact of nutritional supplementation on growth. Journal of Nutrition 1995;125(Suppl 4):1051S‐9S. [MEDLINE: ]
- Iyengar AK, Rao BS, Reddy V. Effect of varying protein and energy intakes on nitrogen balance in Indian preschool children. British Journal of Nutrition 1979;42(3):417‐23.
- Jackson AA, Doherty J, Benoist MH, Hibbert J, Persaud C. The effect of the level of dietary protein, carbohydrate and fat on urea kinetics in young children during rapid catch‐up weight gain. British Journal of Nutrition 1990;64(2):371‐85.
- Jain MK, Heyland D, Dhaliwal R, Day AG, Drover J, Keefe L, Gelula M. Dissemination of the Canadian clinical practice guidelines for nutrition support: results of a cluster randomized controlled trial. Critical Care Medicine 2006;34(9):2362‐9.
- Grantham‐McGregor SM, Powell CA, Walker SP. Nutritional supplements, stunting and child development (letter). Lancet 1989;2:809‐10. [MEDLINE: ]
- Grantham‐McGregor SM, Powell CA, Walker SP, Himes JH. Nutritional supplementation, psychosocial stimulation, and mental development of stunted children: the Jamaica study. Lancet 1991;338(8758):1‐5. [MEDLINE: ]
- Meeks‐Gardner J, Grantham‐McGregor SM, Chang SM, Himes JH, Powell CA. Activity and behavioural development in stunted and non‐stunted children and response to nutritional supplementation. Child Development 1995;66(6):1785‐97.
- Walker SP, Grantham‐McGregor SM, Himes JH, Powell CA, Chang SM. Early childhood supplementation does not benefit the long‐term growth of stunted children in Jamaica. Journal of Nutrition 1996;126(12):3017‐24.
- Walker SP, Powell CA, Grantham‐McGregor SM, Himes JH, Chang SM. Nutritional supplementation, psychosocial stimulation, and growth of stunted children: the Jamaica study. American Journal of Clincial Nutrition 1991;54(4):642‐8.
- Johnson T, MacDonald S, Hill SM, Thomas A, Murphy MS. Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial. Gut 2006;55(3):356‐61.
- Kabir I, Malek MA, Rahman MM, Khaled MA, Mahalanabis D. Changes in body composition of malnourished children after dietary supplementation as measured by bioelectrical impedance. American Journal of Clinical Nutrition 1994;59(1):5‐9.
- Karkos PD, Leong SC, Arya AK, Papouliakos SM, Apostolidou MT, Issing WJ. Complementry ENT: A systematic review of commonly used supplements. Journal of Laryngology & Otology 2007;121(8):779‐82.
- Kashirskaja N, Hill CM, Ilangovan P, Kapranov N, Simonova O, Shabalova L, Rolles CJ. The relative contribution of optimal nutritional support in cystic fibrosis. Journal of the Royal Society of Medicine 1996;89(Suppl 27):48‐50. [MEDLINE: ]
- Kaur P, Bhatt CM. Effect of supplementary feeding on the nutritional status of pre‐school children. Indian Pediatrics 1979; Vol. 16, issue 12:1091‐6. [MEDLINE: ]
- Keele AM, Bray MJ, Emery PW, Silk DBA. Two‐phase randomised controlled clinical trial of oral dietary supplements in surgical patients [abstract]. Proceedings of the 17th European Society of Parenteral & Enteral Nutrition Conference. 1995:8.
- Kendell BD, Fonseca RJ, Lee M. Postoperative nutritional supplementation for the orthognathic surgery patient. Journal of Oral and Maxillofacial Surgery 1982;40(4):205‐13. [MEDLINE: ]
- Heikens GT, Schofield WN, Christie CD, Gernay J, Dawson S. The Kingston Project III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth. European Journal of Clinical Nutrition 1993;47(3):174‐91. [MEDLINE: ]
- Heikens GT, Schofield WN, Dawson S. The Kingston Project II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry. European Journal of Clinical Nutrition 1993;47(3):160‐73. [MEDLINE: ]
- Heikens GT, Schofield WN, Dawson S, Grantham‐McGregor SM. The Kingston Project I. Growth of malnourished children during rehabilitation in the community, given a high energy supplement. European Journal of Clinical Nutrition 1989;43(3):145‐60. [MEDLINE: ]
- Knops N, Wulffraat N, Lodder S, Houwen R, Meer K. Resting energy expenditure and nutritional status in children with juvenile rheumatoid arthritis. Journal of Rheumatology 1999;26(9):2039‐43. [MEDLINE: ]
- Kobayashi K, Katsumata T, Yokoyama K, Takahashi H, Igarashi M, Saigenji K. A randomized controlled study of total parenteral nutrition and enteral nutrition by elemental and polymeric diet as primary therapy in active phase of Crohn's disease. Nippon Shokakibyo Gakkai Zasshi [Japanese Journal of Gastroenterology] 1998;95(11):1212‐21.
- Koletzko B, Ruhl‐Bagheri I, Thiel I, Steinkamp G. Effects of a formula supplement rich in linoleic acid on the essential fatty acid status of cystic fibrosis patients [abstract]. Clinical Nutrition 1992;11:39.
- Steinkamp G, Demmelmair H, Ruhl‐Bagheri I, Hardt H, Koletzko B. Energy supplements rich in linoleic acid improve body weight and essential fatty acid status of cystic fibrosis patients. Journal of Gastroenterology and Nutrition 2000;31(4):418‐23.
- Koretz RL, Avenell A, Lipman TO, Braunschweig CL, Milne AC. Does enteral nutrition affect clinical outcome? A systematic review of the randomised trials. American Journal of Gastroenterology 2007;102(2):412‐429.
- Kossmann J, Nestel P, Herrera MG, Amin A, Fawzi WW. Undernutrition in relation to childhood infections: a prospective study in the Sudan. European Journal of Clinical Nutrition 2000;54(6):463‐72.
- Ladas EJ, Sacks N, Brophy P, Rogers PC. Standards of nutritional care in pediatric oncology: results from a nationwide survey on the standards of practice in pediatric oncology. A children's oncology groups study. Pediatric blood & cancer 2006;46(3):339‐44.
- Lagstrom H, Seppanen R, Jokinen E, Niinikoski H, Ronnemaa T, Viikari J, et al. Influence of dietary fat on the nutrient intake and growth of children from 1 to 5 y of age: the Special Turku Coronary Risk Factor Intervention Project. American Journal of Clinical Nutrition 1999;69(3):516‐23.
- Lambert B, MacDonald A, Booth IW. An open prospective randomised comparison of a newly available high energy enteral feed, with a conventional formula designed for children 1‐6 years [abstract]. Proceedings of the 5th The British Association for Parenteral and Enteral Nutrition Conference. 1995. [MEDLINE: ]
- Lepage G, Yesair DW, Ronco N, Champagne J, Bureau N, Chemtob S, et al. Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis. Journal of Pediatrics 2002;141(2):178‐85.
- Linday LA. Nutritional supplements and pediatric upper respiratory tract illnesses [letter]. Journal of Allergy & Clinical Immunology 2006;117(4):953‐4.
- Linday LA, Shindledecker RD, Tapia‐Mendoza J, Dolitsky JN. Effect of daily cod liver oil and a multivitamin‐mineral supplement with selenium on upper respiratory tract pediatric visits by young, inner‐city, Latino children: randomized pediatric sites.. The Annals of otology, rhinology, and laryngology 2004;113(11):891‐901.
- Lloyd‐Still J, Powers CA, Hoffman DR, Boyd‐Trull K, Lester LA, Benisek DC, et al. A randomized, controlled study examining the bioavailability and safety of an algal docosahexaenoic acid (DHA) triacylglycerol in cystic fibrosis (CF) patients [abstract]. Pediatric Pulmonology 2004;38(Suppl 27):331.
- Lloyd‐Still JD, Powers CA, Hoffman DR, Arterburn LM, Benisek DC, Lester LA. Bioavailability and safety of an algal docosahexaenoic acid (DHA) triglyceride in cystic fibrosis (CF) [abstract]. Pediatric Research 2001;49(4 Suppl):455a.
- Lloyd‐Still JD, Powers CA, Hoffman DR, Boyd‐Trull K, Arterburn LM, Benisek DC, et al. Blood and tissue essential fatty acids after docosahexaenoic acid supplementation in cystic fibrosis [abstract]. Pediatric Pulmonology 2001;32(Suppl 22):263.
- Lloyd‐Still JD, Powers CA, Hoffman DR, Boyd‐Trull K, Lester LA, Benisek DC, et al. Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study. Nutrition 2006;22(1):36‐46.
- Powers CA, Lloyd‐Still JD, Hoffman DR, Arterburn LM, Benisek DC, Lester LA. Lipid soluble antioxidant status during supplementation with algal docosahexaenoic acid triglyceride in CF [abstract]. Proceedings of 24th European Cystic Fibrosis Conference; 2001 June 6‐9; Vienna, Austria. 2001:P133.
- Lutter CK, Rodriguez A, Fuenmayor G, Avila L, Sempertegui F, Escobar J. Growth and micronutrient status in children receiving a fortified complementary food. Journal of nutrition 2008;138(2):379‐88.
- Maes M, Sokal E, Otte JB. Growth factors in children with end‐stage liver disease before and after liver transplantation: a review. Pediatric Transplantation 1997;1(2):171‐5. [MEDLINE: ]
- Mahlungulu S, Grobler LA, Visser ME, Volmink J. Nutritional interventions for reducing morbidity and mortality in people with HIV. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD004536.pub2]
- Manguso F, D'Ambra G, Menchise A, Sollazzo R, D'Agostino L. Effects of an appropriate oral diet on the nutritional status of patients with HCV‐related liver cirrhosis: A prospective study. Clinical Nutrition 2005;24(5):751‐9. [PUBMED: 16182039]
- Marques IL, Barros Almeida Peres SP, Bettiol H, Barbieri MA, Andrea M, Souza L. Growth of children with isolated Robin sequence treated by nasopharyngeal intubation: Importance of a hypercaloric diet. Cleft Palete‐Craniofacial Journal 2004;41(1):53‐8. [PUBMED: 14697069]
- Martorell R, Habicht JP, Rivera JA. History and design of the INCAP longitudinal study (1969‐77) and its follow‐up (1988‐89). Journal of Nutrition 1995;125:1027S‐41S.
- Mathisen B, Worrall L, Masel J, Wall C, Shepherd RW. Feeding problems in infants with gastro‐oesophageal reflux disease: a controlled study. Journal of Paediatrics and Child Health 1999;35(2):163‐9. [MEDLINE: ]
- McCargar LJ, Innis SM, Bowron E, Leichter J, Dawson K, Toth E, et al. Effect of enteral nutritional products differing in carbohydrate and fat on indices of carbohydrate and lipid metabolism in patients with NIDDM. Molecular & Cellular Biochemistry 1998;188(1‐2):81‐9.
- McClure RJ, Newell SJ. Randomised controlled study of clinical outcome following trophic feeding. Archives of Disease in Childhood. Fetal and Neonatal Edition 2000;82(1):F29‐33.
- McWhirter JP, Pennington CR. A comparison between oral and nasogastric nutritional supplements in malnourished patients [abstract]. Proceedings of the 5th British Association of Parenteral and Enteral Nutrition Conference. 1995.
- Mok E, Eleouet‐Da VC, Daubrosse C, Gottrand F, Rigal O, Fontan JE, Cuisset JM, Guilhot J, Hankard R. Oral glutamine and amino acid supplementation inhibit whole‐body protein degradation in children with Duchenne muscular dystrophy. American Journal of Clinical Nutrition 2006;83(4):823‐8.
- Mora JO, Herrera MG, Suescun J, Navarro L, Wagner M. The effects of nutritional supplementation on physical growth of children at risk of malnutrition. American Journal of Clinical Nutrition 1981;34(9):1885‐92. [MEDLINE: ]
- Ndekha MJ, Manary MJ, Ashorn P, Briend A. Home‐based therapy with ready‐to‐use therapeutic food is of benefit to malnourished, HIV‐infected Malawian children. Acta Paediatrica 2005;94(2):222‐5. [PUBMED: 15981758]
- Newby EA, Sawczenko A, Thomas AG, Wilson D. Interventions for growth failure in childhood Crohn's disease. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD003873.pub2]
- Nielsen AA, Nielsen JN, Gronbaek H, Eivindson M, Vind I, Munkholm P, Brandslund I. Impact of enteral supplements enriched with omega‐3 fatty acid and/or omega‐6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion 2007;75(1):10‐6.
- Oudshoorn JH, Klijn PH, Hofman Z, Voorbij HA, Ent CK, Berger R, et al. Dietary supplementation with multiple micronutrients: no beneficial effects in pediatric cystic fibrosis patients. Journal of Cystic Fibrosis 2007;6(1):35‐40.
- Papadopoulou A. Nutritional considerations in children undergoing bone marrow transplantation. European Journal of Clinical Nutrition 1998;52(12):863‐71. [MEDLINE: ]
- Papas K, Kalbfleisch J, Mohon R. Bioavailability of a novel, water‐soluble vitamin E formulation in malabsorbing patients. Digestive Diseases and Sciences 2007;52(2):347‐52.
- Pelekanos JT, Holt TL, Ward LC, Cleghorn GJ, Shepherd RW. Protein turnover in malnourished patients with cystic fibrosis: Effects of elemental and non elemental nutritional supplements. Journal of Pediatric Gastroenterology & Nutrition 1990;10(3):339‐43.
- Powers SW, Schindler T, Schwarber L, Deeks CM, Byars KC, Arthur S, et al. Behavioral treatment to improve nutrition in toddlers with cystic fibrosis [abstract]. Pediatric Pulmonology 1999;Suppl 19:329.
- Powers SW, Piazza‐Waggoner C, Jones JS, Ferguson KS, Daines C, Acton JD. Examining clinical trial results with single‐subject analysis: an example involving behavioural and nutrition treatment for young children with cystic fibrosis. Journal of Pediatric Psychology 2006;31(6):574‐81.
- Raynor P, Rudolf MC, Cooper K, Marchant P, Cottrell D. A randomised controlled trial of specialist health visitor intervention for failure to thrive. Archives of Disease in Childhood 1999;80(6):500‐6. [MEDLINE: ]
- Reifsnider E. Follow‐up study of children with growth deficiency. Western Journal of Nursing Research 1998;20(1):14‐29.
- Reifsnider E. Reversing growth deficiency in children: the effect of a community‐based intervention. Journal of Pediatric Health Care 1998;12(6 Pt 1):305‐12.
- Rettammel AL, Marcus MS, Farrell PM, Sondel SA, Koscil RE, Mischler EH. Oral supplementation with a high‐fat, high‐energy product improves nutritional status and alters serum lipids in patients with cystic fibrosis. Journal of the American Dietetic Association 1996;95:454‐9.
- Rickard KA, Foland BB, Detamore CM, Coates TD, Grosfeld JL, White NM, et al. Effectiveness of central parenteral nutrition versus peripheral parenteral nutrition plus enteral nutrition in reversing protein‐ energy malnutrition in children with advanced neuroblastoma and Wilm's tumor: A prospective randomized study. The American Journal of Clinical Nutrition 1983;38:445‐56.
- Rickard KA, Loghani ES, Grosfeld JL, Detamore CM, White NM, Foland BB, et al. Effectiveness of enteral and parenteral nutrition in preventing and/or reversing PEM in children with advanced neuroblastoma: a prospective randomized study [abstract]. Proceedings of the Annual Meeting of the American Society of Clinical Oncologists. 1984.
- Godshall BJ, Rickard KA, Loghmani ES, Coates TD, Grosfeld JL, Weetman RM, et al. Intergration of nutritional support into oncologic treatment protocols for high and low nutritional risk children with Wilm's tumor: a prospective randomized study [abstract]. Proceedings of the Annual Meeting of the American Society of Clinical Oncologists. 1987. [MEDLINE: ]
- Rickard KA, Detamore CM, Coates TD, Grosfeld JL, Weetman RM, White NM, et al. Effect of nutrition staging on treatment delays and outcome in Stage IV neuroblastoma. Cancer 1983;52:587‐98.
- Rickard KA, Godshall BJ, Loghmani ES, Coates TD, Grosfeld JL, Weetman RM, et al. Integration of nutrition support into oncologic treatment protocols for high and low nutritional risk children with Wilm's tumour. A prospective randomized study. Cancer 1989;64(2):491‐509.
- Rickard KA, Grosfeld JL, Kirksey A, Ballantine TVN, Baehner RL. Reversal of protein energy malnutrition in children during treatment of advanced neoplastic disease. Annals of Surgery 1979;190(6):771‐81.
- Rickard KA, Loghmani ES, Grosfeld JL, Detamore CM, White NM, Foland BB, et al. Effectiveness of enteral and parenteral nutrition in preventing and/or reversing PEM in children with advanced neuroblastoma: a prospective randomised study [abstract]. Proceedings of the Annual Meeting of the American Society of Clinical Oncologists. 1984.
- Rickard KA, Loghmani ES, Grosfeld JL, Lingard CD, White NM, Foland BB, et al. Short‐ and long‐term effectiveness of enteral and parenteral nutrition in reversing or preventing protein‐energy malnutrition in advanced neuroblastoma A prospective randomised study. Cancer 1985;56(12):2881‐97.
- Rock MJ, Davis L, Marcus M, Lai HC, Douglas J, Kosorok M, et al. Early nutritional intervention in infants with CF [abstract]. Pediatric Pulmonology 1999;Suppl 19:102‐3.
- Rollins NC, Broeck J, Kindra G, Pent M, Kasambira T, Bennish ML. The effect of nutritional support on weight gain of HIV‐infected children with prolonged diarrhoea. Acta Paediatrica 2007;96(1):62‐8.
- Saiyed F, Seshadri S. Impact of the integrated package of nutrition and health services. Indian Journal of Pediatrics 2000;67(5):322‐8.
- Shaw WC, Bannister RP, Roberts CT. Assisted feeding is more reliable for infants with clefts‐a randomized trial. The Cleft Palate‐Craniofacial Journal 1999;36(3):262‐8.
- Shepherd RW, Holt TL, Cleghorn G, Ward LC, Isles A, Francis P. Nutritional supplementation during management of pulmonary exacerbations in CF: a controlled study including effects on protein turnover [abstract]. Proceedings of the 10th International Cystic Fibrosis Congress. 1988.
- Shepherd RW, Holt TL, Cleghorn G, Ward LC, Isles A, Francis P. Short‐term nutritional supplementation during management of pulmonary exacerbations in cystic fibrosis: a controlled study, including effects on protein turnover. American Journal of Clinical Nutrition 1988;48(2):235‐9.
- Sirisinha S, Edelman R, Suskind R, Charupatana C, Olsen RE. Complement and C3‐proactive levels in children with protein‐calorie malnutrition and effect of dietary treatment. Lancet 1973; Vol. 1, issue 7811:1016‐20. [MEDLINE: ]
- Soliman AT, El‐Matary W, Abdel Fattah MM, Nasr IS, Alaily RK, Alaa Thabet M. The effect of high‐calorie diet on nutritional parameters of children with beta‐thalassaemia major. Clinical Nutrition 2004;23(5):1153‐8. [PUBMED: 15380908 ]
- Sondel SA, Parrell SW, Becker D, Mischler EH. Oral nutritional supplements in cystic fibrosis. Nutrition Support Services 1987;7(4):20‐2.
- Stark LJ, Hommel KA, Mackner LM, Janicke DM, Davis AM, Pfefferkorn M, et al. Randomized trial comparing two methods of increasing dietary calcium intake in children with inflammatory bowel disease. Journal of Pediatric Gastroenterology & Nutrition 2005;40(4):501‐7. [MEDLINE: ]
- Taylor SJ, Fettes SB, Jewkes C, Nelson RJ. Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury [see comments]. Critical Care Medicine 1999;27(11):2525‐31.
- Teixido‐Planas J, Ortiz A, Coronel F, Montenegro J, Lopez‐Menchero R, Ortiz R, et al. Oral protein‐energy supplements in peritoneal dialysis: A multicentre study. Peritoneal Dialysis International 2005;25(2):163‐72. [PUBMED: 15796145]
- Eys J, Cangir AC. Effect of nutritional supportive therapy on children with advanced cancer. Cancer Research 1982;42(2 Suppl):713‐4s.
- Walker SP, Grantham‐Mcgregor SM, Powell CA, Chang SM. Effects of growth restriction in early childhood on growth, IQ, and cognition at age 11 to 12 years and the benefits of nutritional supplementation and psychosocial stimulation. Journal of Pediatrics 2000;137(1):36‐41.
- Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T, Matsumoto K. Impact of long‐term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: A prospective, non‐randomised, parallel, controlled study. Alimentary Pharmacology & Theraputics 2007;25(1):67‐72.
- Cox SE, Makani J, Walter G, Mtunguja S, Kamala BA, Ellins E, et al. Ready‐to‐use supplementary food supplements improve endothelial function, hemoglobin and growth in Tanzanian children with sickle cell anaemia: the vascular function intervention study (V‐FIT), a random order crossover trial [abstract]. 56th ASH Annual Meeting and Exposition; 2014 Dec 6‐9; San Francisco, California 2014;1:Abstract no: 4087. [CENTRAL: 1017322; CFGD Register: SC262 ; CRS: 5500131000000279]
- Corey M, McLaughlin FJ, Williams M, Levison H. A comparison of survival, growth and pulmonary function in patients with cystic fibrosis in Boston and Toronto. Journal of Clinical Epidemiology 1988;41(6):583‐91.
- Canadian Paediatric Society Nutrition Committee. Undernutrition in children with a neurodevelopmental disability. Canadian Medical Association Journal 1994;151(6):753‐9.
- Curtin F, Elbourne D, Altman DG. Meta‐analysis combining parallel and cross‐over clinical trials. I: Continuous outcomes. Statistics in medicine 2002;21(15):2131‐44.
- Curtin F, Elbourne D, Altman DG. Meta‐analysis combining parallel and cross‐over clinical trials. II: Binary outcomes. Statistics in medicine 2002;21(15):2145‐59.
- Curtin F, Elbourne D, Altman DG. Meta‐analysis combining parallel and cross‐over clinical trials. III: The issue of carry‐over. Statistics in medicine 2002;21(15):2161‐73.
- Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. BMJ 1997;315(7109):629‐34.
- Elbourne DR, Altman DG, Higgins JPT, Curtin F, Worthington HV, Vail A. Meta‐analyses involving cross‐over trials: methodological issues. International Journal of Epidemiology 2002;31(1):140‐9.
- Florescu L, Paduraru DT, Mîndru DE, Temneanu OR, Petrariu FD, Matei MC. Epidemiological evaluation regarding the role of cystic fibrosis as a risk factor for child malnutrition.. Revista Medico‐chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 2014;118(2):450‐6.
- Hendricks KM, Duggan C, Gallagher L, Carlin AC, Richardson DS, Collier SB, et al. Malnutrition in hospitalised pediatric patients: current perspective. Arhives of Pediatrics and Adolescent Medicine 1995;149(10):1118‐22.
- Hendrickse WK, Reilly JJ, Weaver LT. Malnutrition in a children's hospital. Clinical Nutrition 1997;16:13‐8.
- Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing the risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐. Wiley Publishers, 2011.
- Johansson U, Portinsson S, Akesson A, Svantesson H, Ockerman PA, Akesson B. Nutritional status in girls with juvenile chronic arthritis. Human Nutrition: Clinical Nutrition 1986;40(1):57‐67.
- Joosten K F, Zwart H, Hop W C, Hulst J M. National malnutrition screening days in hospitalised children in The Netherlands. Arch Dis Child 2010;95:141‐5.
- Koscik RL, Farrell PM, Kosorok MR, Zaremba KM, Laxova A, Lai HC, et al. Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition. Pediatrics 2004;113(6):1549‐58.
- Moy RJD, Smallman S, Booth IW. Malnutrition in a UK Children's Hospital. Journal of Human Nutrition and Dietetics 1990;3:93‐100.
- Pawellek I, Dokoupil K, Koletzko B. Prevalence of malnutrition in paediatric hospital patients. Clin Nutr 2008;27:72‐6.
- The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
- Smyth RL, Rayner O. Oral calorie supplements for cystic fibrosis. Cochrane Database of Systematic Reviews 2014, Issue 11. [DOI: 10.1002/14651858.CD000406.pub4]
- Spagnuolo M I, Liguoro I, Chiatto F, Mambretti D, Guarino A. Application of a score system to evaluate the risk of malnutrition in a multiple hospital setting. Ital J Pediatr 2013;39:81.
- Poustie VJ, Smyth RL, Watling RM. Oral protein calorie supplementation for children with chronic disease. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD001914]
Source: PubMed