Acupuncture for breathlessness in COVID-19: A protocol for systematic review and meta-analysis

Baozhen Zhang, Kai Zhang, Qilin Tang, Kaihang Sun, Zhenzhen Han, Baozhen Zhang, Kai Zhang, Qilin Tang, Kaihang Sun, Zhenzhen Han

Abstract

Background: At present, accumulative attention has been paid to coronavirus disease 2019 (COVID-19) due to its global prevalence. Acupuncture may play a beneficial role in patients with breathlessness in COVID-19. This study is designed to determine the efficacy and safety of acupuncture for breathlessness in COVID-19.

Methods: Randomized controlled trials (RCT) will be searched from 7 electronic databases, with the last search update being 30 June 2020. Studies by registers of clinical trials will be additionally searched. Two investigators will independently select studies, extract data and evaluate study quality. Finally, a meta-analysis will be used to evaluate the pooled intervention effect if possible.

Results: Our present findings will indicate the application of acupuncture as an adjunctive treatment for dyspnea in COVID-19, which will be published in a peer-reviewed journal.

Conclusion: Our study will provide a reference foundation for clinical optimization of treatment.

Prospero registration number: CRD42020182323.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Types of current evidence on TCM treatment of COVID-19.
Figure 2
Figure 2
Possible related symptoms of COVID-19 treated with acupuncture.
Figure 3
Figure 3
Study selection flow diagram.

References

    1. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 2015;1282:1–23.
    1. Paules CI, Marston HD, Fauci AS. Coronavirus Infections-More Than Just the Common Cold. JAMA 2020.
    1. Del Rio C, Malani PN. COVID-19-new insights on a rapidly changing epidemic. JAMA 2020.
    1. Wang C, Horby PW, Hayden FG, et al. A novel coronavirus outbreak of global health concern. Lancet 2020;395:470–3.
    1. Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA 2020.
    1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054–62.
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020;323:1239–42.
    1. Niu S, Tian S, Lou J, et al. Clinical characteristics of older patients infected with COVID-19: a descriptive study. Arch Gerontol Geriatr 2020;89:104058.
    1. Jin YH, Cai L, Cheng ZS, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res 2020;7:4.
    1. Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther 2020;14:58–60.
    1. Liu X, Zhang M, He L, et al. Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS). Cochrane Database Syst Rev 2012;10:CD004882.
    1. Ren JL, Zhang AH, Wang XJ. Traditional Chinese medicine for COVID-19 treatment. Pharmacol Res 2020;155:104743.
    1. Zhang K. Is traditional Chinese medicine useful in the treatment of COVID-19? Am J Emerg Med 2020.
    1. Zhang K, Tang Q. The dilemma and hope of Traditional Chinese Medicine practitioners in China. Integr Med Res 2020.
    1. Yang Y, Islam MS, Wang J, et al. Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective. Int J Biol Sci 2020;16:1708–17.
    1. von Trott P, Oei SL, Ramsenthaler C. Acupuncture for breathlessness in advanced diseases: a systematic review and meta-analysis. J Pain Symptom Manage 2020;59:327–38. e3.
    1. Zhang K, Li Y, Tang Q. Acupuncture for breathlessness in advanced diseases: methodological issues. J Pain Symptom Manage 2020;59:e3–4.
    1. Kaptchuk TJ. Acupuncture: theory, efficacy, and practice. Ann Intern Med March 2002;136:374–83.
    1. Lovell N, Maddocks M, Etkind SN, et al. Characteristics,symptom management and outcomes of 101 patients with COVID-19 referred for hospital palliative care. J Pain Symptom Manage 2020.
    1. Cheong KB, Zhang JP, Huang Y, et al. The effectiveness of acupuncture in prevention and treatment of postoperative nausea and vomiting--a systematic review and meta-analysis. PLoS One 2013;8:e82474.
    1. Zhang Y, Lin L, Li H, et al. Effects of acupuncture on cancer-related fatigue: a meta-analysis. Support Care Cancer 2018;26:415–25.
    1. Tang Q, Wang S, Zhang K, et al. Interventions for sleep problems during pregnancy: a systematic review. Sleep Med Rev 2020;51:101287.
    1. Lee SH, Lim SM. Acupuncture for insomnia after stroke: a systematic review and meta-analysis. BMC Complement Altern Med 2016;16:228.
    1. Amorim D, Amado J, Brito I, et al. Acupuncture and electroacupuncture for anxiety disorders: a systematic review of the clinical research. Complement Ther Clin Pract 2018;31:31–7.
    1. Tang Q, Zhang K. Association of acupuncture and acupressure with improved cancer pain. JAMA Oncol 2020.
    1. Zhang K, Gao C, Li C, et al. Acupuncture for acute pancreatitis: a systematic review and meta-analysis. Pancreas 2019;48:1136–47.
    1. Zhang K, Li C, Gao C, et al. Efficacy and safety of acupuncture as an adjuvant treatment for acute pancreatitis: a protocol of systematic review and meta-analysis. BMJ Open 2019;9:e029327.
    1. Coyle ME, Shergis JL, Huang ET, et al. Acupuncture therapies for chronic obstructive pulmonary disease: a systematic review of randomized, controlled trials. Altern Ther Health Med 2014;20:10–23.
    1. Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;349:g7647.
    1. National Health Commission of the People's Republic of China.<Guideline on diagnosis and treatment of COVID-19 (Trial 6th edition). . [access date February 23, 2020].
    1. Ahn DG, Shin HJ, Kim MH, et al. Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol 2020;30:313–24.
    1. Aitken RC. Measurement of feelings using visual analogue scales. Proc R Soc Med 1969;62:989–93.
    1. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377–81.
    1. Zhang K, Li Y, Tang Q. Acupuncture for stable angina pectoris: A few noteworthy additions. Eur J Prev Cardiol 2019.
    1. Wang Q, Tang Q, Zhang K. Letter to the editor regarding “acupuncture-induced cranial epidural abscess: case report and review of the literature”. World Neurosurg 2019;132:443.
    1. Tang Q, Tian L, Gao C, et al. The efficacy and safety of Xuebijing injection as an adjunctive treatment for acute pancreatitis: Protocol for a systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore) 2020;99:e18743.
    1. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. .
    1. Zhang K. Is Nigella Sativa Supplementation Effective for Asthma? Am J Emerg Med 2020.
    1. Tang Q, Zhang K. Is endoscopic retrograde cholangiopancreatography safe during pregnancy? Saudi J Gastroenterol 2020;26:61–2.
    1. Zhang K. Water exchange versus air insufflation for colonoscopy: methodological issues of the meta-analysis are a cause for concern. Saudi J Gastroenterol 2019;25:205.
    1. Zhang K. Xuebijing combined with ulinastation for sepsis:a few noteworthy additions. Am J Emerg Med 2020.
    1. Li M, Yang X, Li K, et al. Traditional Chinese medicine for novel coronavirus pneumonia treatment: main force or supplement? Trad Med Res 2020;5:62–4.
    1. Cui HT, Li YT, Guo TY, et al. Traditional Chinese medicine for treatment of coronavirus disease 2019: a review. Trad Med Res 2020;5:65–73.
    1. Zhang K, Tang Q. Acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer. Breast 2019;45:119.
    1. Zhang K, Gao C, Tang Q. Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Respond to author. Support Care Cancer 2019;27:3171–2.
    1. Tang Q, Zhang K. Is acupuncture effective for knee osteoarthritis? Comment on a recent trial. Clin Rehabil 2019;33:1697–8.
    1. Zhang K, Tang Q, Zhao C. Traditional manual acupuncture combined with rehabilitation therapy for shoulder hand syndrome after stroke within the Chinese healthcare system. Clin Rehabil 2019;33:1699–700.
    1. Zhang K, Tang Q, Gao C. Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: a systematic review-methodological issues are a matter for concern. Curr Med Res Opin 2019;35:1319–20.

Source: PubMed

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