Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis

Verônica Colpani, Frederico Soares Falcetta, Augusto Bacelo Bidinotto, Natália Luiza Kops, Maicon Falavigna, Luciano Serpa Hammes, Adele Schwartz Benzaken, Ana Goretti Kalume Maranhão, Carla Magda Allan S Domingues, Eliana Márcia Wendland, Verônica Colpani, Frederico Soares Falcetta, Augusto Bacelo Bidinotto, Natália Luiza Kops, Maicon Falavigna, Luciano Serpa Hammes, Adele Schwartz Benzaken, Ana Goretti Kalume Maranhão, Carla Magda Allan S Domingues, Eliana Márcia Wendland

Abstract

Objectives: This study aimed to estimate the prevalence of genital, anal and oral HPV infection in Brazil through systematic review and meta-analysis.

Methods: We searched EMBASE, LILACS, MEDLINE, Web of Science and SciELO from inception to December 2018. Original research articles that assessed the prevalence of genital (i.e., cervical, penile), anal and oral HPV infection in Brazil were selected in pairs by independent authors. No sex, age, HPV vaccination, language or date restrictions were applied. HPV prevalence was estimated and stratified according to risk factors population and by geographic area throughout the country. The study prevalence was pooled using a random effects model. Analysis was performed using R (version 3.5.2), packages meta version 4.9-4 and metaphor 2.0-0. This review is registered on PROSPERO under protocol number CRD42016032751.

Results: We identified 3,351 references. After the screening process, 139 of them were eligible for this systematic review (57,513 total participants). Prevalence of cervical HPV was 25.41% (95% CI 22.71-28.32). Additionally, prevalence was 36.21% (95% CI 23.40, 51.33) in the penile region, 25.68% (95%CI 14.64, 41.04) in the anal region, and 11.89% (95%CI 6.26, 21.43) in the oral region. Subgroup analysis showed prevalence in each anatomic site was higher in high-risk populations.

Conclusion: The prevalence of HPV is high in the Brazilian population and varies by population risk and anatomic body site, with lower rates in the oral cavity compared to that in the cervical, penile and anal region. Studies on HPV have primarily been developed to evaluate infection and cancer in the cervical region. There is a profound lack of HPV data in many geographic regions of Brazil and for different anatomic sites.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. PRISMA flow diagram for the…
Fig 1. PRISMA flow diagram for the selection of included studies.
Fig 2. Overall prevalence of cervical infection…
Fig 2. Overall prevalence of cervical infection by high-risk HPV genotypes.
Forest plot of a metanalysis of studies reporting prevalence of infection of the cervix by HR-HPV genotypes in Brazil.
Fig 3. Overall prevalence of cervical infection…
Fig 3. Overall prevalence of cervical infection by HPV-16.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV-16 in Brazil.
Fig 4. Overall prevalence of cervical infection…
Fig 4. Overall prevalence of cervical infection by HPV-18.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV-18 in Brazil.
Fig 5. Prevalence of cervical HPV infection…
Fig 5. Prevalence of cervical HPV infection in low-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in low-risk populations in Brazil.
Fig 6. Prevalence of cervical HPV infection…
Fig 6. Prevalence of cervical HPV infection in high-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in high-risk populations in Brazil.
Fig 7. Prevalence of cervical HPV in…
Fig 7. Prevalence of cervical HPV in the South region of Brazil.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in the South region of Brazil.
Fig 8. Prevalence of cervical HPV in…
Fig 8. Prevalence of cervical HPV in the Southeast region of Brazil.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in the Southeast region of Brazil.
Fig 9. Prevalence of cervical HPV in…
Fig 9. Prevalence of cervical HPV in the North region of Brazil.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in the North region of Brazil.
Fig 10. Prevalence of cervical HPV in…
Fig 10. Prevalence of cervical HPV in the Northeast region of Brazil.
Forest plot of a metanalysis of studies reporting prevalence of cervical infection by HPV in the Northeast region of Brazil.
Fig 11. Prevalence of cervical HPV in…
Fig 11. Prevalence of cervical HPV in the Central-West region of Brazil.
Forest plot of a metanlysis of studies reporting prevalence of cervical infection by HPV in the Central-west region of Brazil.
Fig 12. Overall prevalence of penile HPV.
Fig 12. Overall prevalence of penile HPV.
Forest plot of metanalysis of studies reporting prevalence of penile HPV infection in Brazil.
Fig 13. Overall prevalence of penile infection…
Fig 13. Overall prevalence of penile infection by high-risk HPV genotypes.
Forest plot of a metanalysis of studies reporting prevalence of penile infection by HR-HPV genotypes in Brazil.
Fig 14. Prevalence of penile HPV infection…
Fig 14. Prevalence of penile HPV infection in low-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of penile infection by HPV in low-risk populations in Brazil.
Fig 15. Prevalence of penile HPV infection…
Fig 15. Prevalence of penile HPV infection in high-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of penile infection by HPV in high-risk populations in Brazil.
Fig 16. Overall prevalence of anal HPV…
Fig 16. Overall prevalence of anal HPV infection.
Forest plot of a metanalysis of studies reporting prevalence of anal infection by HPV in Brazil.
Fig 17. Overall prevalence of anal infection…
Fig 17. Overall prevalence of anal infection by high-risk HPV genotypes.
Forest plot of a metanalysis of studies reporting prevalence of anal infection by HR-HPV in Brazil.
Fig 18. Prevalence of anal HPV infection…
Fig 18. Prevalence of anal HPV infection in low-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of anal infection by HPV in low-risk populations in Brazil.
Fig 19. Prevalence of anal HPV infection…
Fig 19. Prevalence of anal HPV infection in high-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of anal infection by HPV in high-risk populations in Brazil.
Fig 20. Prevalence of anal HPV infection…
Fig 20. Prevalence of anal HPV infection in Brazil, by region.
Forest plot of a metanalysis of studies reporting prevalence of anal infection by HPV, stratified by region in which each of them took place.
Fig 21. Overall prevalence of oral HPV…
Fig 21. Overall prevalence of oral HPV infection.
Forest plot of a metanalysis of studies reporting prevalence of oral infection by HPV in Brazil.
Fig 22. Overall prevalence of oral infection…
Fig 22. Overall prevalence of oral infection by high-risk HPV genotypes.
Forest plot of a metanalysis of studies reporting prevalence of oral infection by HR-HPV in Brazil.
Fig 23. Prevalence of oral HPV infection…
Fig 23. Prevalence of oral HPV infection in low-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of oral HPV infection in low-risk populations in Brazil.
Fig 24. Prevalence of oral HPV infection…
Fig 24. Prevalence of oral HPV infection in high-risk populations.
Forest plot of a metanalysis of studies reporting prevalence of oral HPV infection in high-risk populations in Brazil.
Fig 25. Prevalence of oral HPV infection…
Fig 25. Prevalence of oral HPV infection in Brazil, by region.
Forest plot of a metanalysis of studies reporting prevalence of oral infection by HPV, stratified by region in which each of them took place.

References

    1. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer; 2018.
    1. Beltrão M, Wanderley MSO, de Santana NA, Bruneska D, de Lima Filho JL. Site of infections associated with human papillomavirus. Arch Gynecol Obstet. 2015;291: 481–491. 10.1007/s00404-014-3480-5
    1. Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, de Sanjosé S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 2010;202: 1789–1799. 10.1086/657321
    1. Giuliano AR, Nyitray AG, Kreimer AR, Pierce Campbell CM, Goodman MT, Sudenga SL, et al. EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection. Int J Cancer. 2015;136: 2752–2760. 10.1002/ijc.29082
    1. Ayres ARG, Silva GA. Cervical HPV infection in Brazil: systematic review. Rev Saúde Pública. 2010;44: 963–974.
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55: 74–108. 10.3322/canjclin.55.2.74
    1. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2005;14: 467–475. 10.1158/1055-9965.EPI-04-0551
    1. Gillison ML, Broutian T, Pickard RKL, Tong Z, Xiao W, Kahle L, et al. Prevalence of Oral HPV Infection in the United States, 2009–2010. JAMA. 2012;307: 693–703. 10.1001/jama.2012.101
    1. Estimativa 2018: Incidência de Câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. Coordenação de Prevenção e Vigilância.–Rio de Janeiro: INCA, 2017. In: INCA—Instituto Nacional de Câncer [Internet]. [cited 27 Mar 2019].
    1. Colpani V, Bidinotto AB, Falavigna M, Giozza SP, Benzaken AS, Pimenta C, et al. Prevalence of papillomavirus in Brazil: a systematic review protocol. BMJ Open. 2016;6: e011884 10.1136/bmjopen-2016-011884
    1. Assessing Cardiovascular Risk: Systematic Evidence Review from the Risk Assessment Work Group | National Heart, Lung, and Blood Institute (NHLBI). [cited 27 Mar 2019].
    1. Iorio A, Spencer FA, Falavigna M, Alba C, Lang E, Burnand B, et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015;350: h870 10.1136/bmj.h870
    1. IntHout J, Ioannidis JPA, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016;6: e010247 10.1136/bmjopen-2015-010247
    1. Alvarez-Argüelles M, Melon S, Villa L, Palacio A, Boga J, Junquera M, et al. Distribution of genotypes of human papilloma virus in women from different countries. Clin Microbiol Infect. 2009;15: S107–S612. 10.1111/j.1469-0691.2009.02858.x
    1. Amaro Filho SM, Nuovo GJ, Cunha CB, de O Ramos Pereira L, Oliveira-Silva M, Russomano F, et al. Correlation of MCM2 detection with stage and virology of cervical cancer. Int J Biol Markers. 2014;29: e363–371. 10.5301/jbm.5000081
    1. Amorim AT, Marques LM, Campos GB, Lobão TN, Souza Lino V, Cintra RC, et al. Co-infection of sexually transmitted pathogens and Human Papillomavirus in cervical samples of women of Brazil. BMC Infect Dis. 2017;17.
    1. Araujo MP, Kleine HT, Parmigiano TR, Gomes NT, Caparroz GP, Silva IDCG, et al. Prevalence of sexually transmitted diseases in female athletes in São Paulo, Brazil. Einstein São Paulo. 2014;12: 31–35. 10.1590/S1679-45082014AO2949
    1. Augusto EF, Santos LS, Oliveira L do H dos S, Augusto EF, Santos LS, Oliveira L do H dos S. Human papillomavirus detection in cervical scrapes from women attended in the Family Health Program. Rev Lat Am Enfermagem. 2014;22: 100–107. 10.1590/0104-1169.3189.2398
    1. Ayres ARG, Silva GA, Teixeira MTB, Duque K de CD, Machado MLSM, Gamarra CJ, et al. HPV in women assisted by the Family Health Strategy. Rev Saúde Pública. 2017;51: 92 10.11606/S1518-8787.2017051000065
    1. Balbi F do SM. Estudo da prevalência da infecção pelo Papiloma Vírus Humano (HPV) em mulheres no climatério em um hospital de referência de Belém. Universidade Federal do Pará. 2015.
    1. Baldin-Dal Pogetto MR, Silva MG, Parada CMG de L. Prevalence of sexually transmitted diseases in female sex workers in a city in the interior of São Paulo, Brazil. Rev Lat Am Enfermagem. 2011;19: 493–499. 10.1590/S0104-11692011000300007
    1. Batista JE, Saddi VA, Carvalho KPA, Ribeiro AA, Segati KD, Carneiro MA dos S, et al. Human papillomavirus genotypes 68 and 58 are the most prevalent genotypes in women from quilombo communities in the state of Maranhão, Brazil. Int J Infect Dis. 2017;55: 51–55. 10.1016/j.ijid.2017.01.001
    1. Becker E, Edelweiss MI, Nonnenmacher B, Bozzetti MC. Prevalence and epidemiologic correlates of atypical squamous cells of undetermined significance in women at low risk for cervical cancer. Diagn Cytopathol. 2001;24: 276–282. 10.1002/dc.1059
    1. Boon ME, Veen G, Barlow Y, Graudenz MS, Kok LP. Presence of proliferating (MiB-1-positive) cells in cervical smears of women infected with HIV is associated with clinical outcome: a study of Brazilian women. Diagn Cytopathol. 2001;24: 373–377. 10.1002/dc.1083
    1. Brito EB, Martins SJ, Menezes RC. Human papillomaviruses in Amerindian women from Brazilian Amazonia. Epidemiol Infect. 2002;128: 485–489. 10.1017/s0950268802006908
    1. Caixeta RCA, Ribeiro AA, Segatti KD, Saddi VA, Figueiredo Alves RR, Santos Carneiro MA, et al. Association between the human papillomavirus, bacterial vaginosis and cervicitis and the detection of abnormalities in cervical smears from teenage girls and young women. Diagn Cytopathol. 2015;43: 780–785. 10.1002/dc.23301
    1. Campos ACC, Murta EFC, Michelin MA, Reis C. Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus. ISRN Obstet Gynecol. 2012;2012: 342075 10.5402/2012/342075
    1. Campos KLM, Machado AP, Almeida FG, Bonin CM, Prata TTM, Almeida LZ, et al. Good agreements between self and clinician-collected specimens for the detection of human papillomavirus in Brazilian patients. Mem Inst Oswaldo Cruz. 2014;109: 352–355. 10.1590/0074-0276130397
    1. Cassel APR, Barcellos RB, Silva CMD, Matos Almeida SE, Rossetti MLR. Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology. Genet Mol Biol. 2014;37: 360–363. 10.1590/s1415-47572014005000010
    1. Ceccato BPV Junior, Lopes APC, Nascimento LF, Novaes LM, Melo VH, Ceccato BPV Junior, et al. Prevalence of cervical infection by human papillomavirus and cervical intraepithelial neoplasia in HIV-positive and negative women. Rev Bras Ginecol E Obstetrícia. 2015;37: 178–185. 10.1590/SO100-720320150005184
    1. Chagas BS, Comar M, Gurgel APAD, Paiva S, Seraceni S, Freitas AC, et al. Association Study between Cervical Lesions and Single or Multiple Vaccine-Target and Non-Vaccine Target Human Papillomavirus (HPV) Types in Women from Northeastern Brazil. PLoS One. 2015;10: e0132570 10.1371/journal.pone.0132570
    1. Coser J, Rocha Boeira T, Simon D, Kazantzi Fonseca AS, Ikuta N, Lunge VR. Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil. Genet Mol Res GMR. 2013;12: 4276–4285. 10.4238/2013.February.19.3
    1. Coser J, Boeira T da R, Wolf JM, Cerbaro K, Simon D, Lunge VR. Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil. Braz J Infect Dis. 2016;20: 61–68. 10.1016/j.bjid.2015.10.008
    1. Costa-Lira E, Jacinto AHVL, Silva LM, Napoleão PFR, Barbosa-Filho RAA, Cruz GJS, et al. Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology. Genet Mol Res GMR. 2017;16: gmr16029626. 10.4238/gmr16029626
    1. da Silva MC, Martins HPR, Souza JL, Tognim MCB, Svidzinski TIE, Teixeira JJV, et al. Prevalence of HPV infection and genotypes in women with normal cervical cytology in the state of Paraná, Brazil. Arch Gynecol Obstet. 2012;286: 1015–1022. 10.1007/s00404-012-2399-y
    1. de Abreu AL, Malaguti N, Souza RP, Uchimura NS, Ferreira ÉC, Pereira MW, et al. Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion. Am J Cancer Res. 2016;6: 1371–1383.
    1. de Aguiar SRV, Villanova FE, Martins LC, Santos MS, de P Maciel J, Falcão LFM, et al. Human papillomavirus: prevalence and factors associated in women prisoners population from the Eastern Brazilian Amazon. J Med Virol. 2014;86: 1528–1533. 10.1002/jmv.23972
    1. de Almeida FG, Machado AP, Fernandes CEDS, Ferreira AT, Padovani CTJ, Tozetti IA. Molecular epidemiology of the human papillomavirus infection in self-collected samples from young women. J Med Virol. 2014;86: 266–271. 10.1002/jmv.23725
    1. De Brot L, Pellegrini B, Moretti ST, Carraro DM, Soares FA, Rocha RM, et al. Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix. Cancer Cytopathol. 2017;125: 138–143. 10.1002/cncy.21789
    1. de Mattos AT, Freitas LB, Lima BMC, Miranda AE, Spano LC. Diversity and uncommon HPV types in HIV seropositive and seronegative women attending an STI clinic. Braz J Microbiol. 2011;42: 786–793.
    1. de Melo Kuil L, Lorenzi AT, Stein MD, Resende JCP, Antoniazzi M, Longatto-Filho A, et al. The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytol. 2017;61: 425–433. 10.1159/000477331
    1. de Oliveira GR, Vieira VC, Ávila EC, Finger-Jardim F, Caldeira TD, Gatti FA, et al. Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions. Mem Inst Oswaldo Cruz. 2017;112: 492–498. 10.1590/0074-02760160530
    1. dos Santos JC, dos S Cezar MR, Lisboa MR, Moura MM da F. Occurrence of human papillomavirus in uterine cervix of women in the western Brazilian Amazon. Acta Amaz. 2013;43: 185–190. 10.1590/S0044-59672013000200008
    1. Duarte D, Vieira R, Brito E, Pinheiro M, Monteiro J, Valente M, et al. Prevalence of Human Papillomavirus Infection and Cervical Cancer Screening among Riverside Women of the Brazilian Amazon. Rev Bras Ginecol E Obstetrícia. 2017;39: 350–357. 10.1055/s-0037-1604027
    1. Eluf-Neto J, Booth M, Muñoz N, Bosch FX, Meijer CJ, Walboomers JM. Human papillomavirus and invasive cervical cancer in Brazil. Br J Cancer. 1994;69: 114–119. 10.1038/bjc.1994.18
    1. Fedrizzi EN, Schlup CG, Menezes ME, Ocampos M. Infecção pelo Papilomavírus Humano (HPV) em Mulheres HIV-Positivo de Florianópolis, Santa Catarina. J Bras Doenças Sex Transm DST. 2008;20: 73–79.
    1. Fedrizzi EN, Villa LL, Souza IV, Sebastião APM, Urbanetz AA, De Carvalho NS. Does human papillomavirus play a role in endometrial carcinogenesis? Int J Gynecol Pathol. 2009;28: 322–327. 10.1097/PGP.0b013e318199943b
    1. de M Fernandes TAA, de V Meissner R, Bezerra LF, Azevedo PRM, Fernandes JV. Human papillomavirus infection in women attended at a cervical cancer screening service in Natal, Brazil. Braz J Microbiol. 2008;39: 573–578.
    1. Figueiredo Alves RR, Turchi MD, Santos LE, Guimarães EM de B, Garcia MMD, Seixas MSC, et al. Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiânia, Brazil: a community-based study. BMC Public Health. 2013;13 10.1186/1471-2458-13-1041
    1. Fonseca AJ, Taeko D, Chaves TA, Amorim LD da C, Murari RSW, Miranda AE, et al. HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest. PLOS ONE. 2015;10: e0133635 10.1371/journal.pone.0133635
    1. Franco EL, Villa LL, Ruiz A, Costa MC. Transmission of cervical human papillomavirus infection by sexual activity: differences between low and high oncogenic risk types. J Infect Dis. 1995;172: 756–763. 10.1093/infdis/172.3.756
    1. Freitas LB, Pereira CC, Checon R, Leite JPG, Nascimento JP, Spano LC. Adeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women. Eur J Obstet Gynecol Reprod Biol. 2009;145: 41–44. 10.1016/j.ejogrb.2009.03.024
    1. Gadelha SR, Soares-Barreto DMV, Costa GB, Leal VCN, Gomes LGS, Santos UR, et al. Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil. Epidemiol Infect. 2017;145: 3398–3404. 10.1017/S0950268817002448
    1. Gillio-Tos A, Bicalho M da G, Fiano V, Grasso C, Tarallo V, De Marco L, et al. Case-control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis. BMC Cancer. 2012;12: 618 10.1186/1471-2407-12-618
    1. Girianelli VR, Thuler LCS, Silva GA. [Prevalence of HPV infection among women covered by the family health program in the Baixada Fluminense, Rio de Janeiro, Brazil]. Rev Bras Ginecol E Obstet Rev Fed Bras Soc Ginecol E Obstet. 2010;32: 39–46.
    1. Golfetto L, Alves EV, Martins TR, Sincero TCM, Castro JBS, Dannebrock C, et al. PCR-RFLP assay as an option for primary HPV test. Braz J Med Biol Res. 2018;51 10.1590/1414-431x20177098
    1. Holanda F, Castelo A, Veras TMCW, Almeida FML, Lins MZ, Dores GB. Primary screening for cervical cancer through self sampling. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2006;95: 179–184. 10.1016/j.ijgo.2006.07.012
    1. Igansi CN, Santos VK, Rosa MI, Rosa MTM, Calil LN, Cortez-Herrera E, et al. Infecção genital pelo HPV e Chlamydia trachomatis em mulheres assintomáticas: prevalência, fatores associados e relação com lesões cervicais. Cad Saúde Coletiva. 2012;20: 287–96.
    1. Krambeck WM, Cadidé RM, Dalmarco EM, Cordova CMM. HPV detection and genotyping as an earlier approach in cervical cancer screening of the female genital tract. Clin Exp Obstet Gynecol. 2008;35: 175–178.
    1. Leite KRM, Silva T, Naum B, Canavez F, Canavez J, Pimenta R, et al. Validation of a New Low-Cost, Methanol-Based Fixative for Cervical Cytology and Human Papillomavirus Detection. Acta Cytol. 2018;62: 393–396. 10.1159/000489873
    1. Lima L, Hoelzle C, Simões R, Lima M, Fradico J, Mateo E, et al. Sexually Transmitted Infections Detected by Multiplex Real Time PCR in Asymptomatic Women and Association with Cervical Intraepithelial Neoplasia. Rev Bras Ginecol E Obstetrícia RBGO Gynecol Obstet. 2018;40: 540–546. 10.1055/s-0038-1669994
    1. Lippman SA, Sucupira MCA, Jones HE, Luppi CG, Palefsky J, Wijgert JHHM, et al. Prevalence, distribution and correlates of endocervical human papillomavirus types in Brazilian women. Int J STD AIDS. 2010;21: 105–109. 10.1258/ijsa.2009.008436
    1. Lopes F, Latorre M do RD de O, Pignatari ACC, Buchalla CM. HIV, HPV, and syphilis prevalence in a women’s penitentiary in the city of São Paulo, 1997–1998. Cad Saúde Pública. 2001;17: 1473–1480.
    1. Lorenzato F, Ho L, Terry G, Singer A, Santos LC, De Lucena Batista R, et al. The use of human papillomavirus typing in detection of cervical neoplasia in Recife (Brazil). Int J Gynecol Cancer Off J Int Gynecol Cancer Soc. 2000;10: 143–150.
    1. Lorenzi AT, Fregnani JHT, Possati-Resende JC, Antoniazzi M, Scapulatempo-Neto C, Syrjänen S, et al. Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas? Cancer Cytopathol. 2016;124: 581–588. 10.1002/cncy.21718
    1. Lugo LZA, Jacob CMB, Machado AP, Almeida FG, Ávila LS, Prata TTM, et al. Human papillomavirus and coinfections with Chlamydia trachomatis, Gardnerella vaginalis, and Trichomonas vaginalis in self-collected samples from female sex workers in the Central-Western region of Brazil. J Bras Patol E Med Lab. 2018;54: 46–51. 10.5935/1676-2444.20180010
    1. Martins TR, Fedrizzi EN, Alves EV, Vituri CL, Silva RM, Bazzo ML. Cervical Cytology, HPV DNA and MRNA—A Comparative Study in 162 Patients. J Bras Doenças Sex Transm DST. 2012;24: 79–84. 10.5533/DST-2177-8264-201224203
    1. Martins TR, Mendes de Oliveira C, Rosa LR, Campos Centrone C, Rodrigues CLR, Villa LL, et al. HPV genotype distribution in Brazilian women with and without cervical lesions: correlation to cytological data. Virol J. 2016;13: 138 10.1186/s12985-016-0594-3
    1. Martins TR, Longatto-Filho A, Cohen D, Viscondi JYK, Fuza LM, Cury L, et al. Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening. Am J Clin Pathol. 2018;149: 316–323. 10.1093/ajcp/aqx163
    1. McCormick TM, Canedo NHS, Furtado YL, Silveira FA, Lima RJ, Rosman ADF, et al. Association between human papillomavirus and Epstein—Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study. Diagn Pathol. 2015;10: 59 10.1186/s13000-015-0283-3
    1. Miranda PM, Silva NNT, Pitol BCV, Silva IDCG, Lima-Filho JL, Carvalho RF, et al. Persistence or clearance of human papillomavirus infections in women in Ouro Preto, Brazil. BioMed Res Int. 2013;2013: 578276 10.1155/2013/578276
    1. Muñoz N, Kato I, Bosch FX, Eluf-Neto J, De Sanjosé S, Ascunce N, et al. Risk factors for HPV DNA detection in middle-aged women. Sex Transm Dis. 1996;23: 504–510. 10.1097/00007435-199611000-00012
    1. Naud P, Matos J, Hammes L, Stuckzynski J, Brouwers K, Magno V, et al. Factors predicting intermediate endpoints of cervical cancer and exposure to human papillomavirus (HPV) infections in young women screened as potential targets for prophylactic HPV vaccination in south of Brazil. Eur J Obstet Gynecol Reprod Biol. 2006;124: 110–118. 10.1016/j.ejogrb.2005.02.001
    1. Nonato DR, Alves RRF, Ribeiro AA, Saddi VA, Segati KD, Almeida KP, et al. Prevalence and factors associated with coinfection of human papillomavirus and Chlamydia trachomatis in adolescents and young women. Am J Obstet Gynecol. 2016;215: 753.e1–753.e9. 10.1016/j.ajog.2016.07.003
    1. Nonnenmacher B, Breitenbach V, Villa LL, Prolla JC, Bozzetti MC. Identificação do papilomavírus humano por biologia molecular em mulheres assintomáticas. Rev Saúde Pública. 2002;36: 95–100.
    1. Noronha VL, Cruz EM, Pinho CN, Mello WA, Villa LL, Russomano FB. Papilomavírus humano (HPV) em mulheres submetidas a rastreamento para câncer de cérvice uterina, Belém—Pará—Brasil. J Bras Doenças Sex Transm DST. 2011;23: 5–11. 10.5533/2177-8264-201123103
    1. Oliveira FA, Pfleger V, Lang K, Heukelbach J, Miralles I, Fraga F, et al. Sexually transmitted infections, bacterial vaginosis, and candidiasis in women of reproductive age in rural Northeast Brazil: a population-based study. Mem Inst Oswaldo Cruz. 2007;102: 751–756. 10.1590/s0074-02762007000600015
    1. Oliveira LHS, Ferreira MDPL, Augusto EF, Melgaço FG, Santos LS, Cavalcanti SMB, et al. Human papillomavirus genotypes in asymptomatic young women from public schools in Rio de Janeiro, Brazil. Rev Soc Bras Med Trop. 2010;43: 4–8. 10.1590/s0037-86822010000100002
    1. Oliveira GR, Vieira VC, Barral MFM, Döwich V, Soares MA, Conçalves CV, et al. Fatores de risco e prevalência da infecção pelo HPV em pacientes de Unidades Básicas de Saúde e de um Hospital Universitário do Sul do Brasil. Rev Bras Ginecol E Obstetrícia. 2013;35: 226–232.
    1. Padovani CTJ, Bonin CM, Tozetti IA, Ferreira AMT, dos S Fernandes CE, Costa IP. Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection. Rev Soc Bras Med Trop. 2013;46: 288–292. 10.1590/0037-8682-0029-2013
    1. Paesi S, Correa L, Tregnago MC, Mandelli J, Roesch-Ely M. Human papillomavirus among women with atypical squamous cells of undetermined significance in southern Brazil. Int J Gynecol Obstet. 2015;128: 23–26. 10.1016/j.ijgo.2014.07.027
    1. Peres AL, Camarotti JRSL, Cartaxo M, Alencar N, Stocco RC, Beçak W, et al. Molecular analysis and conventional cytology: association between HPV and bacterial vaginosis in the cervical abnormalities of a Brazilian population. Genet Mol Res. 2015;14: 9497–9505. 10.4238/2015.August.14.13
    1. Pinheiro MCN, Baia de Brito E, Nascimento Pinheiro D, Emanuelle Sanches Borges B, Silva Soares E, Antônia Nunes Gomes J, et al. Principais genótipos de papilomavírus humano em mulheres ribeirinhas na Amazônia brasileira. Rev Bras Em Promoção Saúde. 2016;29: 68–74. 10.5020/18061230.2016.p68
    1. Pinto D da S, Fuzii HT, Quaresma JAS. Prevalence of genital HPV infection in urban and rural women in the Eastern Brazilian Amazon. Cad Saúde Pública. 2011;27: 769–778. 10.1590/s0102-311x2011000400016
    1. Porcari AM, Negrão F, Tripodi GL, Pitta DR, Campos EA, Montis DM, et al. Molecular Signatures of High-Grade Cervical Lesions. Front Oncol. 2018;8: 99 10.3389/fonc.2018.00099
    1. Rama CH, Roteli-Martins CM, Derchain SFM, Oliveira EZ, Aldrighi JM, Mariani Neto C. Serological detection of anti HPV 16/18 and its association with pap smear in adolescents and young women. Rev Assoc Médica Bras. 2006;52: 43–47. 10.1590/S0104-42302006000100021
    1. Rama CH, Villa LL, Pagliusi S, Andreoli MA, Costa MC, Thomann P, et al. Opportunity for catch-up HPV vaccination in young women after first delivery. J Epidemiol Community Health. 2010;64: 610–615. 10.1136/jech.2008.086439
    1. Resende LS de A, Rabelo-Santos SH, Sarian LO, Figueiredo Alves RR, Ribeiro AA, Zeferino LC, et al. A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions. BMC Infect Dis. 2014;14: 214 10.1186/1471-2334-14-214
    1. Richardson LA, El-Zein M, Ramanakumar AV, Ratnam S, Sangwa-Lugoma G, Longatto-Filho A, et al. HPV DNA testing with cytology triage in cervical cancer screening: Influence of revealing HPV infection status: HPV/Pap: Concealed Versus Revealed HPV. Cancer Cytopathol. 2015;123: 745–754.
    1. Rocha DAP, Barbosa Filho RAA, de Queiroz FA, dos Santos CMB. High Prevalence and Genotypic Diversity of the Human Papillomavirus in Amazonian Women, Brazil. Infect Dis Obstet Gynecol. 2013;2013: 514859 10.1155/2013/514859
    1. Rodrigues DA, Pereira ÉR, Oliveira LS de S, Speck NM de G, Gimeno SGA, Rodrigues DA, et al. Prevalence of cytological atypia and high-risk human papillomavirus infection in Panará indigenous women in Central Brazil. Cad Saúde Pública. 2014;30: 2587–2593.
    1. Rodrigues LLS, Morgado MG, Sahasrabuddhe VV, De Paula VS, Oliveira NS, Chavez-Juan E, et al. Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors. Gynecol Oncol. 2018;151: 102–110. 10.1016/j.ygyno.2018.08.004
    1. Rosa MI, Fachel JMG, Rosa DD, Medeiros LR, Igansi CN, Bozzetti MC. Persistence and clearance of human papillomavirus infection: a prospective cohort study. Am J Obstet Gynecol. 2008;199: 617.e1–7 10.1016/j.ajog.2008.06.033
    1. Roteli-Martins CM, Carvalho NS, Naud P, Teixeira J, Borba P, Derchain S, et al. Prevalence of human papillomavirus infection and associated risk factors in young women in Brazil, Canada, and the United States: a multicenter cross-sectional study. Int J Gynecol Pathol. 2011;30: 173–184. 10.1097/PGP.0b013e3181f38dfe
    1. Salcedo MMBP, Damin APS, Agnes G, Pessini SA, Beitune PE, Alexandre COP, et al. Prevalence of human papillomavirus infection in pregnant versus non-pregnant women in Brazil. Arch Gynecol Obstet. 2015;292: 1273–1278. 10.1007/s00404-015-3752-8
    1. Santos CR, Franciscatto LG, Barcellos RB, Almeida SEM, Rossetti MLR. Use of FTA elute card impregnated with cervicovaginal sample directly into the amplification reaction increases the detection of human papillomavirus DNA. Braz J Microbiol. 2012;43: 389–392.
    1. Santos Filho MVC, Gurgel APAD, Lobo CDP, Freitas ACF, Silva-Neto JC, Silva LAF. Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women. Genet Mol Res. 2016;15: gmr8315. 10.4238/gmr.15028315
    1. Silva KC, Rosa MLG, Moyse N, Afonso LA, Oliveira LH, Cavalcanti SM. Risk factors associated with human papillomavirus infection in two populations from Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2009;104: 885–891. 10.1590/s0074-02762009000600011
    1. Simões R, Silva E, Barth O. Lb3.246 Prevalence and risk factors of human papillomavirus infection in unimmunized women in brazil. Sex Transm Infect. 2017;93: A185–A186. 10.1136/sextrans-2017-053264.481
    1. Smith JS, Muñoz N, Herrero R, Eluf-Neto J, Ngelangel C, Franceschi S, et al. Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines. J Infect Dis. 2002;185: 324–331. 10.1086/338569
    1. Soares CP, Benatti Neto C, Fregonezi PAG, Teresa DB, de M Santos RT, Longatto Filho A, et al. Computer-assisted analysis of p53 and PCNA expression in oral lesions infected with human papillomavirus. Anal Quant Cytol Histol. 2003;25: 19–24.
    1. Ströher DJ, Aramburu TDB, Nunes VT. Analysis of cytopathologic examination and hybrid capture in women receiving care in basic health units. J Bras Doenças Sex Transm DST. 2016;28: 110–114.
    1. Syrjänen K, Naud P, Derchain S, Roteli-Martins C, Longatto-Filho A, Tatti S, et al. Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS study. Anticancer Res. 2005;25: 3469–3480.
    1. Tamegão-Lopes BP, Sousa-Júnior EC, Passetti F, Ferreira CG, Mello WA, Duarte Silvestre RV. Prevalence of human papillomavirus infection and phylogenetic analysis of HPV-16 E6 variants among infected women from Northern Brazil. Infect Agent Cancer. 2014;9: 25 10.1186/1750-9378-9-25
    1. Teixeira LO, Vieira VC, Germano FN, Gonçalves CV, Soares MA, Martinez AMB. Prevalence of Human Papillomavirus types in women attending at University hospital in southern Brazil. Medicina (Mex). 2016;49: 116.
    1. Torres KL, Mariño JM, Pires Rocha DA, Mello MB, Melo Farah HH, Reis R dos S, et al. Self-sampling coupled to the detection of HPV 16 and 18 E6 protein: A promising option for detection of cervical malignancies in remote areas. Tornesello ML, editor. PLoS One. 2018;13: e0201262 10.1371/journal.pone.0201262
    1. Tota JE, Ramanakumar AV, Villa LL, Richardson H, Burchell AN, Coutlée F, et al. Cervical Infection With Vaccine-Associated Human Papillomavirus (HPV) Genotypes as a Predictor of Acquisition and Clearance of Other HPV Infections. J Infect Dis. 2016;214: 676–684. 10.1093/infdis/jiw215
    1. Trugilo KP, Cebinelli GCM, Berti FCB, Okuyama NCM, Cezar-dos-Santos F, Sena MM, et al. Polymorphisms in the TGFB1 signal peptide influence human papillomavirus infection and development of cervical lesions. Med Microbiol Immunol (Berl). 2019;208: 49–58. 10.1007/s00430-018-0557-y
    1. Vieira RC, Monteiro J do SV, Manso EP, Dos Santos MRM, Tsutsumi MY, Ishikawa EAY, et al. Prevalence of type-specific HPV among female university students from northern Brazil. Infect Agent Cancer. 2015;10: 21 10.1186/s13027-015-0017-x
    1. Waisberg MG, Ribeiro ACM, Candido WM, Medeiros PB, Matsuzaki CN, Beldi MC, et al. Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study. Rheumatol Int. 2015;35: 459–463. 10.1007/s00296-014-3157-1
    1. Wohlmeister D, Vianna DRB, Helfer VE, Gimenes F, Consolaro MEL, Barcellos RB, et al. Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples. Mem Inst Oswaldo Cruz. 2016;111: 106–113. 10.1590/0074-02760150330
    1. Xavier-Souza E, Rapp A, Teles P, Timbó M, Lessa K, Trindade R, et al. Risk factors associated to STI in female adolescents attending a reference centre in Bahia, Brazil. Int J Gynecol Obstet. 2018;143: EP0555.
    1. Yamamoto LSU, Alves VAF, Maeda MYS, Longatto-Filho A, Utagawa ML, Eluf Neto J. A morphological protocol and guide-list on uterine cervix cytology associated to Papillomavirus infection. Rev Inst Med Trop São Paulo. 2004;46: 189–193. 10.1590/s0036-46652004000400003
    1. Afonso LA, Cordeiro TI, Carestiato FN, Ornellas AA, Alves G, Cavalcanti SMB. High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. J Urol. 2016;195: 1784–1789. 10.1016/j.juro.2015.12.096
    1. Eleutério J, Barros IC, Cavalcante DIM, Eleutério RMN, Giraldo PC. HPV-DNA hybrid capture test: influence of cellularity in penile samples. Acta Cytol. 2010;54: 546–550. 10.1159/000325175
    1. Franceschi S, Castellsagué X, Dal Maso L, Smith JS, Plummer M, Ngelangel C, et al. Prevalence and determinants of human papillomavirus genital infection in men. Br J Cancer. 2002;86: 705–711. 10.1038/sj.bjc.6600194
    1. Giraldo PC, Eleutério J, Cavalcante DIM, Gonçalves AKS, Romão JAA, Eleutério RMN. The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions. Eur J Obstet Gynecol Reprod Biol. 2008;137: 88–91. 10.1016/j.ejogrb.2006.12.026
    1. Menezes W, Ceperuelo DL, Cordeiro TI, Dobao E, Gouvêa TVD, Carestiato FN, et al. Human papillomavirus infection in healthy men from Rio de Janeiro, Brazil. J Bras Doenças Sex Transm DST. 2014;26: 21–24. 10.5533/DST-2177-8264-2014261-405
    1. Rocha MG de L, Faria FL, Gonçalves L, Souza M do CM, Fernandes PÁ, Fernandes AP. Prevalence of DNA-HPV in male sexual partners of HPV-infected women and concordance of viral types in infected couples. PLoS One. 2012;7: e40988 10.1371/journal.pone.0040988
    1. Rocha WM, Afonso LA, Dobao E, Gouvea TD, Carestiato FN, Cavalcanti SMB. Evaluation of anogenital Human Papillomavirus Infection in asymptomatic men from Rio de Janeiro, Brazil. Rev Patol Trop. 2015;44: 375–385.
    1. Rombaldi RL, Serafini EP, Villa LL, Vanni AC, Baréa F, Frassini R, et al. Infection with human papillomaviruses of sexual partners of women having cervical intraepithelial neoplasia. Braz J Med Biol Res. 2006;39: 177–187. 10.1590/s0100-879x2006000200003
    1. Silva RJC, Casseb J, Andreoli MA, Villa LL. Persistence and clearance of HPV from the penis of men infected and non-infected with HIV. J Med Virol. 2011;83: 127–131. 10.1002/jmv.21950
    1. Sudenga SL, Torres BN, Silva R, Villa LL, Lazcano-Ponce E, Abrahamsen M, et al. Comparison of the Natural History of Genital HPV Infection among Men by Country: Brazil, Mexico, and the United States. Cancer Epidemiol Biomarkers Prev. 2017;26: 1043–1052. 10.1158/1055-9965.EPI-17-0040
    1. Eleutério J, Benício GC, Giraldo PC, Gonçalves AKS, Eleutério RMN, Oliveira DN, et al. Liquid-based cytology and HPV DNA testing using intra-anal specimens from HIV-negative women with and without genital HPV-induced lesions. Diagn Cytopathol. 2015;43: 360–365. 10.1002/dc.23238
    1. Nyitray AG, Smith D, Villa L, Lazcano-Ponce E, Abrahamsen M, Papenfuss M, et al. Prevalence of and risk factors for anal human papillomavirus infection in men who have sex with women: a cross-national study. J Infect Dis. 2010;201: 1498–1508. 10.1086/652187
    1. Soares PC, Ferreira S, Villa LL, Matos D. Identification of human papillomavirus in patients with anal squamous cell carcinoma and its relation with the grade of cellular differentiation and staging. Rev Bras Coloproctologia. 2011;31: 8–16. 10.1590/S0101-98802011000100002
    1. Sudenga SL, Nyitray AG, Torres BN, Silva R, Villa L, Lazcano-Ponce E, et al. Comparison of anal HPV natural history among men by country of residence: Brazil, Mexico, and the United States. J Infect. 2017;75: 35–47. 10.1016/j.jinf.2017.03.010
    1. Veo CAR, Saad SS, Fregnani JHTG, Scapulatempo-Neto C, Tsunoda AT, Resende JCP, et al. Clinical characteristics of women diagnosed with carcinoma who tested positive for cervical and anal high-risk human papillomavirus DNA and E6 RNA. Tumour Biol J Int Soc Oncodevelopmental Biol Med. 2015;36: 5399–5405. 10.1007/s13277-015-3205-9
    1. Antunes LCM, Lopes A de B, Pacheco LS, Brites PC, Muller LB, Fagundes RB. No role for infection with human papillomavirus in upper aerodisgestive tract cancers in smokers and alcoholics. J Clin Oncol. 2012;30: e14597–e14597.
    1. Araújo MV de A, Pinheiro HHC, Pinheiro J de JV, Quaresma JAS, Fuzii HT, Medeiros RC. Prevalência do papilomavírus humano (HPV) em Belém, Pará, Brasil, na cavidade oral de indivíduos sem lesões clinicamente diagnosticáveis. Cad Saúde Pública. 2014;30: 1115–1119.
    1. Cavenaghi VB, Ghosn EJE, Cruz N, Rossi LM, da Silva L, Costa HO, et al. Determination of HPV prevalence in oral/oropharyngeal mucosa samples in a rural district of São Paulo. Braz J Otorhinolaryngol. 2013;79: 599–602. 10.5935/1808-8694.20130107
    1. da Silva CEX dos SR, Silva IDCG, Cerri A, Weckx LLM. Prevalence of human papillomavirus in squamous cell carcinoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104: 497–500. 10.1016/j.tripleo.2007.04.028
    1. do Sacramento PR, Babeto E, Colombo J, Cabral Ruback MJ, Bonilha JL, Fernandes AM, et al. The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population. J Med Virol. 2006;78: 614–618. 10.1002/jmv.20583
    1. Esquenazi D, Bussoloti Filho I, Carvalho M da G da C, Barros FS. The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR. Braz J Otorhinolaryngol. 2010;76: 78–84.
    1. Gonçalves AKS, Giraldo P, Barros-Mazon S, Gondo ML, Amaral RL, Jacyntho C. Secretory immunoglobulin A in saliva of women with oral and genital HPV infection. Eur J Obstet Gynecol Reprod Biol. 2006;124: 227–231. 10.1016/j.ejogrb.2005.06.028
    1. Horewicz VV, Feres M, Rapp GE, Yasuda V, Cury PR. Human papillomavirus-16 prevalence in gingival tissue and its association with periodontal destruction: a case-control study. J Periodontol. 2010;81: 562–568. 10.1902/jop.2009.090571
    1. Kreimer AR, Pierce Campbell CM, Lin H-Y, Fulp W, Papenfuss MR, Abrahamsen M, et al. Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet. 2013;382: 877–887. 10.1016/S0140-6736(13)60809-0
    1. Machado AP, Gatto de Almeida F, Bonin CM, Martins Prata TT, Sobrinho Ávilla L, Junqueira Padovani CT, et al. Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men. Braz J Infect Dis. 2014;18: 266–270. 10.1016/j.bjid.2013.07.013
    1. Marques AEM, Barra GB, Resende Oyama CN, Guerra ENS. Low rate of oropharyngeal human papillomavirus infection of women with cervical lesions and their partners: new data from Brazilian population. J Oral Pathol Med. 2015;44: 453–458. 10.1111/jop.12252
    1. Oliveira LHS, Santos LS, Silva CO, Augusto EF, Neves FPG. Papillomavirus infections in the oral and genital mucosa of asymptomatic women. Braz J Infect Dis. 2017;21: 88–91. 10.1016/j.bjid.2016.08.015
    1. Peixoto AP, Campos GS, Queiroz LB, Sardi SI. Asymptomatic oral human papillomavirus (HPV) infection in women with a histopathologic diagnosis of genital HPV. J Oral Sci. 2011;53: 451–459. 10.2334/josnusd.53.451
    1. Silva CO, Santos LS, Pereira OMD, Azevedo KML, Oliveira LHS. High frequency of human papillomavirus type 53 in oral cavity of asymptomatic HIV-infected people. Braz J Infect Dis. 2016;20: 111–112. 10.1016/j.bjid.2015.10.006
    1. Tristão W, Ribeiro RMP, Oliveira CA, Betiol JC, Bettini J de SR. Epidemiological study of HPV in oral mucosa through PCR. Braz J Otorhinolaryngol. 2012;78: 66–70. 10.1590/S1808-86942012000400013
    1. Vidotti LR, Vidal FCB, Monteiro SCM, Nunes JD, Salgado JV, Brito LMO, et al. Association between oral DNA-HPV and genital DNA-HPV. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2014;43: 289–292. 10.1111/jop.12141
    1. Xavier SD, Bussoloti Filho I, Carvalho JM, Castro TMPPG, Framil VM de S, Syrjänen KJ. Prevalence of human papillomavirus (HPV) DNA in oral mucosa of men with anogenital HPV infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108: 732–737. 10.1016/j.tripleo.2009.06.020
    1. Zonta MA, Monteiro J, Santos G Jr, Pignatari ACC. Infecção oral pelo HPV em mulheres com lesão escamosa de colo uterino no sistema prisional da cidade de São Paulo, Brasil. Braz J Otorhinolaryngol. 2012;78: 66–72.
    1. Bomfim-Hyppólito S, Eleuterio J, Nunes GC, Bomfim-Hyppólito E, Franco ES, Neto R da JP. HIV or human papillomavirus co-infection among Brazilian individuals infected with hepatitis B and/or hepatitis C. Int J Gynecol Obstet. 2013;122: 258–260. 10.1016/j.ijgo.2013.04.012
    1. Soares CC, Georg I, Lampe E, Lewis L, Morgado MG, Nicol AF, et al. HIV-1, HBV, HCV, HTLV, HPV-16/18, and Treponema pallidum infections in a sample of Brazilian men who have sex with men. PloS One. 2014;9: e102676 10.1371/journal.pone.0102676
    1. Stiepcich MM, Silva ID, Scarpellini B. Abstract 5506: HPV genotyping of 15,307 Brazilian patients using a microarray based platform. Cancer Res. 2012;72: 5506–5506. 10.1158/1538-7445.AM2012-5506
    1. Afonso LA, Rocha WM, Carestiato FN, Dobao EA, Pesca LF, Passos MRL, et al. Human papillomavirus infection among sexual partners attending a Sexually Transmitted Disease Clinic in Rio de Janeiro, Brazil. Braz J Med Biol Res. 2013;46: 533–538. 10.1590/1414-431X20132519
    1. Autran R, Mont’Alverne R, Eleuterio J, Melo KMRL, Rebouças KCF, Moraes A, et al. Correlation between cytology and DNA-HPV screening of the cervix and anus of immunocompetent women. Int J Gynecol Obstet. 2018;143: 433.
    1. Beder Ribeiro CM, Ferrer I, Santos de Farias AB, Fonseca DD, Morais Silva IH, Monteiro Gueiros LA, et al. Oral and genital HPV genotypic concordance between sexual partners. Clin Oral Investig. 2014;18: 261–268. 10.1007/s00784-013-0959-6
    1. Carestiato FN, Silva KC, Dimetz T, Oliveira LHS, Cavalcanti SMB. Prevalence of human papillomavirus infection in the genital tract determined by hybrid capture assay. Braz J Infect Dis. 2006;10: 331–336. 10.1590/s1413-86702006000500006
    1. Castro TMPPG, Bussoloti Filho I, Nascimento VX, Xavier SD. HPV detection in the oral and genital mucosa of women with positive histopathological exam for genital HPV, by means of the PCR. Rev Bras Otorrinolaringol. 2009;75: 167–171.
    1. Lima MDM, Braz-Silva PH, Pereira SM, Riera C, Coelho AC, Gallottini M. Oral and cervical HPV infection in HIV-positive and HIV-negative women attending a sexual health clinic in São Paulo, Brazil. Int J Gynaecol Obstet. 2014;126: 33–36. 10.1016/j.ijgo.2014.01.017
    1. Nicolau SM, Camargo CGC, Stávale JN, Castelo A, Dôres GB, Lörincz A, et al. Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection. Urology. 2005;65: 251–255. 10.1016/j.urology.2004.09.031
    1. Rosenblatt C, Lucon AM, Pereyra E a. G, Pinotti JA, Arap S, Ruiz CA. HPV prevalence among partners of women with cervical intraepithelial neoplasia. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2004;84: 156–161. 10.1016/j.ijgo.2003.08.008
    1. Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global Burden of Human Papillomavirus and Related Diseases. Vaccine. 2012;30: F12–F23. 10.1016/j.vaccine.2012.07.055
    1. Brasil, Instituto Brasileiro de Geografia e Estatística. Sinopse do censo demográfico : 2010. Rio de Janeiro: IBGE; 2011.
    1. Brasil, IBGE, Coordenação de População e Indicadores Sociais. Tábua completa de mortalidade para o Brasil [: análises e tabelas]. Rio de Janeiro: IBGE, Coordenação de População e Indicadores Sociais; 2018.
    1. de Oliveira MM, de A Andrade SSC, de Oliveira PPV, Silva GA e, da Silva MMA, Malta DC. Cobertura de exame Papanicolaou em mulheres de 25 a 64 anos, segundo a Pesquisa Nacional de Saúde e o Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico, 2013. Rev Bras Epidemiol. 2018;21: e180014.
    1. Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, et al. Prevalence of HPV infection among females in the United States. JAMA. 2007;297: 813–819. 10.1001/jama.297.8.813
    1. Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, Sanjosé S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 2010;202: 1789–1799. 10.1086/657321
    1. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR. Prevalence of HPV infection among men: A systematic review of the literature. J Infect Dis. 2006;194: 1044–1057. 10.1086/507432
    1. Giuliano AR, Lazcano-Ponce E, Villa LL, Flores R, Salmeron J, Lee J-H, et al. The Human Papillomavirus Infection in Men Study: Human Papillomavirus Prevalence and Type Distribution among Men Residing in Brazil, Mexico, and the United States. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2008;17: 2036–2043. 10.1158/1055-9965.EPI-08-0151
    1. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR. Prevalence of HPV infection among men: A systematic review of the literature. J Infect Dis. 2006;194: 1044–1057. 10.1086/507432
    1. Tam S, Fu S, Xu L, Krause KJ, Lairson DR, Miao H, et al. The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis. Oral Oncol. 2018;82: 91–99. 10.1016/j.oraloncology.2018.04.005
    1. Syrjänen K, Pyrhönen S, Aukee S, Koskela E. Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). Diagn Histopathol. 1982;5: 291–296.
    1. Liyanage SS, Rahman B, Ridda I, Newall AT, Tabrizi SN, Garland SM, et al. The Aetiological Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma: A Meta-Analysis. PLOS ONE. 2013;8: e69238 10.1371/journal.pone.0069238
    1. de Matos LL, Miranda GA, Cernea CR, de Matos LL, Miranda GA, Cernea CR. Prevalence of oral and oropharyngeal human papillomavirus infection in Brazilian population studies: a systematic review. Braz J Otorhinolaryngol. 2015;81: 554–567. 10.1016/j.bjorl.2015.04.001
    1. Brasil, Ministério da Saúde, Secretaria de Vigilância em Saúde, Depratamento de Vigilânida das Doenças Transmissíveis, Coordenação-geral do Programa Nacional de Imunizações. Informe técnico da ampliação da oferta das vacinas papilomavírus humano 6, 11, 16 e 18 (recombinante)–vacina HPV quadrivalente e meningocócica C (conjugada). Brasília; 2018 Mar.
    1. Smith JS, Melendy A, Rana RK, Pimenta JM. Age-specific prevalence of infection with human papillomavirus in females: a global review. J Adolesc Health Off Publ Soc Adolesc Med. 2008;43: S5–25, S25.e1–41. 10.1016/j.jadohealth.2008.07.009
    1. Wendland EM, Caierão J, Domingues C, Maranhão AGK, de Souza FMA, Hammes LS, et al. POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil. BMJ Open. 2018;8: e021170 10.1136/bmjopen-2017-021170

Source: PubMed

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