Anemia of Chronic Renal Disease

Hira Shaikh, Muhammad F. Hashmi, Narothama R. Aeddula, Hira Shaikh, Muhammad F. Hashmi, Narothama R. Aeddula

Excerpt

Anemia is generally defined as hemoglobin of less than 13.0 g/dL in men and less than 12.0 g/dL in premenopausal women. Anemia of chronic kidney disease (CKD) is a form of normocytic normochromic, hypoproliferative anemia. Among other complications of CKD, it is frequently associated with poor outcomes in CKD and increased mortality.

The disorder starts to develop when the glomerular filtration rate drops below 60 mg/ml. The anemia is rare when the GFR exceeds 80 mL/min/1.73 m2. However, as the GFR worsens, the anemia gets more severe.

Anemia is one of the common associations of CKD responsible for poor outcomes. The current management options for anemia in CKD are controversial, with some clinical trials indicating raised morbidity and mortality associated with erythropoiesis-stimulating agents. One hundred seventy years ago, anemia was linked to CKD for the first time by Richard Bright. With the progression of kidney disease, the prevalence of anemia increases affecting almost all patients with stage 5 CKD. Anemia of chronic renal disease often leads to declined quality of life and increased risk of cardiovascular diseases, cognitive impairment, hospitalizations, and mortality.

Conflict of interest statement

Disclosure: Hira Shaikh declares no relevant financial relationships with ineligible companies.

Disclosure: Muhammad Hashmi declares no relevant financial relationships with ineligible companies.

Disclosure: Narothama Aeddula declares no relevant financial relationships with ineligible companies.

Copyright © 2024, StatPearls Publishing LLC.

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