Predicting adherence of patients with HF through machine learning techniques

Georgia Spiridon Karanasiou, Evanthia Eleftherios Tripoliti, Theofilos Grigorios Papadopoulos, Fanis Georgios Kalatzis, Yorgos Goletsis, Katerina Kyriakos Naka, Aris Bechlioulis, Abdelhamid Errachid, Dimitrios Ioannis Fotiadis, Georgia Spiridon Karanasiou, Evanthia Eleftherios Tripoliti, Theofilos Grigorios Papadopoulos, Fanis Georgios Kalatzis, Yorgos Goletsis, Katerina Kyriakos Naka, Aris Bechlioulis, Abdelhamid Errachid, Dimitrios Ioannis Fotiadis

Abstract

Heart failure (HF) is a chronic disease characterised by poor quality of life, recurrent hospitalisation and high mortality. Adherence of patient to treatment suggested by the experts has been proven a significant deterrent of the above-mentioned serious consequences. However, the non-adherence rates are significantly high; a fact that highlights the importance of predicting the adherence of the patient and enabling experts to adjust accordingly patient monitoring and management. The aim of this work is to predict the adherence of patients with HF, through the application of machine learning techniques. Specifically, it aims to classify a patient not only as medication adherent or not, but also as adherent or not in terms of medication, nutrition and physical activity (global adherent). Two classification problems are addressed: (i) if the patient is global adherent or not and (ii) if the patient is medication adherent or not. About 11 classification algorithms are employed and combined with feature selection and resampling techniques. The classifiers are evaluated on a dataset of 90 patients. The patients are characterised as medication and global adherent, based on clinician estimation. The highest detection accuracy is 82 and 91% for the first and the second classification problem, respectively.

Keywords: cardiology; chronic disease; diseases; heart failure; learning (artificial intelligence); machine learning techniques; medication; nutrition; patient adherence prediction; patient monitoring; patient treatment; physical activity.

Figures

Fig. 1
Fig. 1
Flowchart for the prediction of adherence of the patient

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