Evaluation of the effect of hydrogen peroxide as a mouthwash in comparison with chlorhexidine in chronic periodontitis patients: A clinical study

Hazem Tarek Rashed, Hazem Tarek Rashed

Abstract

Aims and objective: This study was conducted to evaluate the effect of hydrogen peroxide (H2O2) as a mouthwash in comparison with chlorhexidine (CHX) in chronic periodontitis patients.

Materials and methods: A total of 45 patients suffering from localized mild to moderate chronic periodontitis were chosen. The subjects were divided equally into three groups. Group A patients were treated only with scaling and root planning (SRP). Group B were treated with SRP in combination with 0.2% CHX gluconate mouthwash twice daily for 10 days. Group C were treated with SRP in combination with 1.5% H2O2 mouthwash twice daily for 10 days. Gingival index, plaque index, pocket depth, and clinical attachment level were recorded for patients of all groups on day 0 (Baseline), 15, 30, and 90, respectively. Statistical analysis was done using the Statistical Package for the Social Sciences version 22.0. Repeated measures analysis of variance was used to assess the differences in the abovementioned indices because of time and groups.

Results: Both CHX gluconate and H2O2 mouthwashes significantly reduced the gingival index more than that observed in the control group, but similar to each other. There were no significant differences in the clinical attachment loss, plaque index, and pocket depth among the study groups, but improvement was seen within the CHX group participants. In participants with chronic periodontitis, SRP in combination with 0.2% CHX gluconate mouthwash was an effective treatment in reducing the gingival index and the pocket depth, as well as improving the clinical attachment level.

Conclusion: The use of CHX gluconate was observed to be higher than H2O2 for the reduction in the gingival index and the pocket depth, as well as for the improvement of the clinical attachment level.

Keywords: Chlorhexidine gluconate; chronic periodontitis; hydrogen peroxide.

Figures

Appendix 1
Appendix 1
Consort flow diagram
Figure 1
Figure 1
Change in gingival index across time in the study groups. Effect of time [F = 430.28, P< 0.0001; a, b, c, and d: Different letters denoting significant difference between follow up period]. Effect of groups [F = 10.12, P< 0.0001; A and B: Different letters denoting significant difference between the follow-up period]
Figure 2
Figure 2
Change in plaque index across time in the study groups. Effect of time [F = 291.73, P< 0.0001; a, b, c, and d: Different letters denoting significant difference between the follow-up period]. Effect of groups [F = 2.33, P= 0.11]
Figure 3
Figure 3
Change in pocket depth across time in the study groups. Effect of time [F = 596.36, P< 0.0001; a, b, c, and d: Different letters denoting significant difference between follow-up period]; effect of groups [F = 2.95, P = 0.06]
Figure 4
Figure 4
Change in the clinical attachment level across time in the study groups. Effect of time [F = 1.60, P = 0.21]; effect of groups [F = 0.02, P= 0.98]

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