Adding Adjuvants to Fluoropyrimidine-based Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: An Option Worthy of Serious Consideration

Fengpeng Wu, Chaoxi Zhou, Bingyuan Wu, Xiaoxiao Zhang, Kanghua Wang, Jun Wang, Linlin Xiao, Guiying Wang, Fengpeng Wu, Chaoxi Zhou, Bingyuan Wu, Xiaoxiao Zhang, Kanghua Wang, Jun Wang, Linlin Xiao, Guiying Wang

Abstract

The application of fluoropyrimidine-based neoadjuvant chemoradiotherapy (Fu-nCRT) of locally advanced rectal cancer (LARC) has become a common therapeutic regimen. In order to improve the efficacy and enable more patients to benefit from this treatment, an accumulation of studies have been carried out on the auxiliary use of other drugs with Fu-nCRT. However, due to specific challenges and the potential opportunities that coexist in this field, a more reasonable approach to the mode of treatment remains to be explored. In this review, we have summarized the results of the studies on the combination of Fu-nCRT with cytotoxic drugs, anti-tumor angiogenesis, and anti-EGFR agents, as well as the status of the application of immune checkpoint inhibitors in the neoadjuvant therapy of LARC patients.

Keywords: adjuvants; cytotoxic chemotherapeutic drugs; immune checkpoint inhibitors; locally advanced rectal cancer; molecular targeted anticancer drugs; neoadjuvant chemoradiotherapy.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

© The author(s).

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Source: PubMed

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