Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome

Md Ashraful Alam, Md Mahbubur Rahman, Md Ashraful Alam, Md Mahbubur Rahman

Abstract

Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency. This deficiency has been implicated in several clinical disorders such as heart failure, hypertension, Parkinson's disease and obesity. The lipid lowering drug statin inhibits conversion of HMG-CoA to mevalonate and lowers plasma Co-Q10 concentrations. However, supplementation with Co-Q10 improves the pathophysiological condition of statin therapy. Recent evidence suggests that Co-Q10 supplementation may be useful for the treatment of obesity, oxidative stress and the inflammatory process in metabolic syndrome. The anti-inflammatory response and lipid metabolizing effect of Co-Q10 is probably mediated by transcriptional regulation of inflammation and lipid metabolism. This paper reviews the evidence showing beneficial role of Co-Q10 supplementation and its potential mechanism of action on contributing factors of metabolic and cardiovascular complications.

Keywords: Co-enzyme Q10; Inflammation; Metabolic syndrome; Obesity; Oxidative stress.

Figures

Figure 1
Figure 1
Schematic diagram of Co-Q10, Mito-Q and Idebenone.
Figure 2
Figure 2
Proposed mechanism of Co-Q supplementation on anti-inflammatory and lipid metabolism pathways in tissues in case of metabolic syndrome. AMPK, Adenosine monophosphate activated protein kinase; PPAR, Peroxisome proliferator activated receptor; PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator-1; oxLDL, Oxidized Low density lipoprotein; NRF, nuclear respiration factor; LXR, Liver X receptor; PPRE PPAR response element.

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