Technical report: an online international weight control registry to inform precision approaches to healthy weight management

Susan B Roberts, Sai Krupa Das, R Drew Sayer, Ann E Caldwell, Holly R Wyatt, Tapan S Mehta, Anna M Gorczyca, Jennifer L Oslund, John C Peters, James E Friedman, Chia-Ying Chiu, Frank L Greenway, Joseph E Donnelly, Maria Carlota Dao, Adolfo G Cuevas, Olivia Affuso, Larrell L Wilkinson, Diana Thomas, Ebaa Al-Ozairi, Mary Yannakoulia, Yeganeh M Khazrai, Raoul J Manalac, Vasil Bachiashvili, James O Hill, Susan B Roberts, Sai Krupa Das, R Drew Sayer, Ann E Caldwell, Holly R Wyatt, Tapan S Mehta, Anna M Gorczyca, Jennifer L Oslund, John C Peters, James E Friedman, Chia-Ying Chiu, Frank L Greenway, Joseph E Donnelly, Maria Carlota Dao, Adolfo G Cuevas, Olivia Affuso, Larrell L Wilkinson, Diana Thomas, Ebaa Al-Ozairi, Mary Yannakoulia, Yeganeh M Khazrai, Raoul J Manalac, Vasil Bachiashvili, James O Hill

Abstract

Background: Personalizing approaches to prevention and treatment of obesity will be a crucial aspect of precision health initiatives. However, in considering individual susceptibility to obesity, much remains to be learned about how to support healthy weight management in different population subgroups, environments and geographical locations.

Subjects/methods: The International Weight Control Registry (IWCR) has been launched to facilitate a deeper and broader understanding of the spectrum of factors contributing to success and challenges in weight loss and weight loss maintenance in individuals and across population groups. The IWCR registry aims to recruit, enroll and follow a diverse cohort of adults with varying rates of success in weight management. Data collection methods include questionnaires of demographic variables, weight history, and behavioral, cultural, economic, psychological, and environmental domains. A subset of participants will provide objective measures of physical activity, weight, and body composition along with detailed reports of dietary intake. Lastly, participants will be able to provide qualitative information in an unstructured format on additional topics they feel are relevant, and environmental data will be obtained from public sources based on participant zip code.

Conclusions: The IWCR will be a resource for researchers to inform improvements in interventions for weight loss and weight loss maintenance in different countries, and to examine environmental and policy-level factors that affect weight management in different population groups. This large scale, multi-level approach aims to inform efforts to reduce the prevalence of obesity worldwide and its associated comorbidities and economic impacts.

Trial registration: NCT04907396 (clinicaltrials.gov) sponsor SB Roberts; Tufts University IRB #13075.

Conflict of interest statement

The IWCR was launched in the United States with a grant from the NIH awarded to the Nutrition Obesity Research Center (NORC) at the University of Alabama Birmingham (NIH project number 3P30DK056336-19S1, primary sponsor for JOH); a grant from the United States Department of Agriculture awarded to Tufts University (USDA/ARS project number 8050-51000-105-00D, primary sponsor for SBR); a grant from the NIH awarded to the University of Colorado NORC (NIH project number 2P30DK048520-26, secondary sponsor); and a small, 1-year unrestricted gift from Gelesis Inc. Dr. Roberts founded the iDiet, a web-based behavioral weight loss program (www.theidiet.com), and is a Board member of Danone. Dr. Hill has ownership interests in Shakabuku LLC. He has received research grants from National Cattleman’s Beef Association and owns a patent for the Energy Gap. He has received consulting fees from Gelesis and has stock options in the company. Dr. Sayer has no financial conflicts of interest directly related to the IWCR. He has received research grants for nutrition and obesity-related studies from General Mills, National Cattlemen’s Beef Association, and Gelesis. Dr. Wyatt has ownership interests in Shakabuku LLC and Dr Holly LLC. She has received research grants from Novo Nordisk, Epitomee, National Cattleman’s Beef Association, and Gelesis. She has received speaking fees from Novo Nordisk and a consulting fee from Gelesis and Roman Health. She is the author of the book entitled State of Slim that is published by Rodale. She owns a patent for the Energy Gap. Dr. Greenway owns stock in Slim Health Nutrition, Ketogenic Health Systems, UR Labs, Plensat, Energesis and Rejuvenate Bio. He is a consultant to Academic Technology Venures, General Nutrition Corporation, Basic Research, Novmeta Pharma and Jazz Pharmaceuticals. Dr. Greenway has a shared patent with Melior Discoveries, and he is on the scientific advisory board for Pfizer and Gelesis. The remaining authors have no relevant conflicts of interest to disclose.

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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