Tourniquet Use During Knee Replacement Surgery May Contribute to Muscle Atrophy in Older Adults
Hans C Dreyer, Hans C Dreyer
Abstract
Muscle atrophy after total knee arthroplasty (TKA) occurs at a rate of 1% per day for the first 2 wk. Our hypothesis is that tourniquet-induced ischemia-reperfusion injury occurring during TKA influences metabolism and may contribute to atrophy. Identifying pathways that are upregulated during this critical "14-d window" after surgery may help us delineate therapeutic approaches to avoid muscle loss.
Trial registration: ClinicalTrials.gov NCT02145949.
Conflict of interest statement
Conflict of Interest Statement: The author declares that no conflict of interest exists.
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Source: PubMed