Comparison of assisted reproductive technology outcomes in infertile women with polycystic ovary syndrome: In vitro maturation, GnRH agonist, and GnRH antagonist cycles

Min Hye Choi, Sun Hee Lee, Hye Ok Kim, Sun Hwa Cha, Jin Young Kim, Kwang Moon Yang, In Ok Song, Mi Kyoung Koong, Inn Soo Kang, Chan Woo Park, Min Hye Choi, Sun Hee Lee, Hye Ok Kim, Sun Hwa Cha, Jin Young Kim, Kwang Moon Yang, In Ok Song, Mi Kyoung Koong, Inn Soo Kang, Chan Woo Park

Abstract

Objective: We compared the assisted reproductive technology (ART) outcomes among infertile women with polycystic ovary syndrome (PCOS) treated with IVM, conventional IVF, GnRH agonist, and GnRH antagonist cycles.

Methods: The prospective study included a total of 67 cycles in 61 infertile women with PCOS. The women with PCOS were randomized into three IVF protocols: IVM/IVF with FSH and hCG priming with immature oocyte retrieval 38 hours later (group A, 14 cycles), GnRH agonist long protocol (group B, 14 cycles), and GnRH antagonist multi-dose flexible protocol (group C, 39 cycles). IVF outcomes, such as clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR), were compared among the three groups.

Results: Age, BMI, and basal FSH and LH levels did not differ among the three groups. The number of retrieved oocytes and 2 pronucleus embryos was significantly lower in group A compared with groups B and C. The CPR, IR, MR, and LBR per embryo transfer showed no differences among the three groups. There was no incidence of ovarian hyperstimulation syndrome in group A.

Conclusion: The IR, MR, and LBR in the IVM cycles were comparable to those of the GnRH agonist and GnRH antagonist cycles. The IVM protocol, FSH and hCG priming with oocyte retrieval 38 hours later, is an effective ART option that is comparable with conventional IVF for infertile women with PCOS.

Keywords: Assisted reproductive technology outcome; GnRH agonist; GnRH antagonist; In vitro maturation; Polycystic ovary syndrome.

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Source: PubMed

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