Predictors of nonresponse and drop-out among children and adolescents receiving TF-CBT: investigation of client-, therapist-, and implementation factors

Ane-Marthe Solheim Skar, Nora Braathu, Tine K Jensen, Silje Mørup Ormhaug, Ane-Marthe Solheim Skar, Nora Braathu, Tine K Jensen, Silje Mørup Ormhaug

Abstract

Background: There is a paucity of evidence about effective implementation strategies to increase treatment response and prevent drop-out among children receiving evidence-based treatment. This study examines patient, therapist, and implementation factors and their association to nonresponse and drop-out among youth receiving Trauma-Focused Cognitive Behavioral Therapy (TF-CBT).

Methods: Youth (n = 1240) aged 6-18 (M = 14.6) received TF-CBT delivered by 382 TF-CBT therapists at 66 clinics. Odds ratio analyses were used to investigate whether pretreatment child (age, gender, number of trauma experiences, post-traumatic stress symptoms (PTSS), therapist (education), and implementation strategy factors (high-low, low-low, low-high intensity therapist and leadership training respectively) or tele-mental health training during the Covid-19 pandemic are associated with nonresponse (above clinical PTSS level post-treatment) and drop-out (therapist-defined early termination). Fidelity checks were conducted to ensure that TF-CBT was used consistently.

Results: One fourth of the children (24.4%) were nonresponders and 13.3 percent dropped out. Exposure to three or more traumatic experiences were related to nonresponse and drop-out. Higher baseline PTSS was related to a higher probability of nonresponse. There was no effect of therapist education or child gender on nonresponse and drop-out, whereas children over 15 years had a higher likelihood of both. After controlling for baseline PTSS, the effect of age on nonresponse was no longer significant. Drop-out was related to fewer sessions, and most dropped out during the first two phases of TF-CBT. Fidelity was high throughout the different implementation phases. High-intensity therapist training was related to a lower probability of both nonresponse and drop-out, whereas low therapist and leadership training were related to a higher likelihood of both. Multivariate analysis revealed higher child age and higher PTSS baseline scores as significant predictors of nonresponse, and number of trauma experiences (> = 3) at baseline as the only predictor of drop-out.

Conclusions: High-intensity therapist training seem key to prevent patient nonresponse and drop-out. Leadership training might positively affect both, although not enough to compensate for less intensive therapist training. More complex cases (higher PTSS and exposure to more traumas) predict nonresponse and drop-out respectively, which underscores the importance of symptom assessment to tailor the treatment. The lack of predictive effect of therapist education increases the utilization of TF-CBT.

Trial registration: Retrospectively registered in ClinicalTrials, ref. nr. NCT05248971.

Keywords: Attrition; Evidence-based practice; Treatment interruption.

Conflict of interest statement

The authors declare that they have no competing interests.

© 2022. The Author(s).

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Implementation strategies

References

    1. Aarons GA, Ehrhart MG, Farahnak LR, Hurlburt MS. Leadership and organizational change for implementation (LOCI): a randomized mixed method pilot study of a leadership and organization development intervention for evidence-based practice implementation. Implement Sci. 2015;10:11. doi: 10.1186/s13012-014-0192-y.
    1. Aarons GA, Ehrhart MG. (2022). Leading implementation by focusing on strategic implementation leadership. Implementation Science, 1st Edition, Routledge.
    1. Akoglu H. User's guide to correlation coefficients. Turk J Emerg Med. 2018;18(3):91–93. doi: 10.1016/j.tjem.2018.08.001.
    1. Alisic E, Zalta AK, Wesel F, Larsen SE, Smid GE. Rates of posttraumatic stress disorder in trauma-exposed children and adolescents: meta-analysis. Br J Psychiatry. 2014;204:335–340. doi: 10.1192/bjp.bp.113.131227.
    1. Amaya-Jackson L, Hagele D, Sideris J, Potter D, Briggs EC, Keen L, Murphy RA, Dorsey S, Parchett V, Ake GS, Socolar R. Pilot to policy: Statewide dissemination and implementation of evidence-based treatment for traumatized youth. BMC Health Serv Res. 2018;18(1):589. doi: 10.1186/s12913-018-3395-0.
    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth edition. (DSM-5). 2013.
    1. Bates, D., Maechler, M., Bolker, B., Walker, S., Christensen, R. H., Singmann, H., Krivitsky, P. N. (2021). LME4: Linear mixed-effects models using 'Eigen' and S4. Retrieved November 6, 2021, from
    1. Bear HA, Edbrooke-Childs J, Norton S, Krause KR, Wolpert M. Systematic review and meta-analysis: outcomes of routine specialist mental health care for young people with depression and/or anxiety. Child AdolescPsychiatr. 2020;59(7):810–841.
    1. Borge RH, Egeland KM, Aarons GA, Ehrharat MG, Sklar M, Skar A-MS. “Change Doesn’t Happen by Itself”: A Thematic Analysis of First-Level Leaders’ Experiences Participating in the Leadership and Organizational Change for Implementation (LOCI) Strategy. Adm Policy Ment Health. 2022;542:5.
    1. Borrelli B, Sepinwall D, Ernst D, Orwig D. A new tool to assess treatment fidelity and evaluation of treatment fidelity across 10 years of health behavior research. J Consult Clin Psychol. 2005;73(5):852–860. doi: 10.1037/0022-006X.73.5.852.
    1. Cohen JA, Deblinger E, Mannarino AP, Steer R. A Multi-site, randomized controlled trial for children with abuse-related PTSD symptoms. J Am Acad Child Adolesc Psychiatry. 2004;43(4):393–402. doi: 10.1097/00004583-200404000-00005.
    1. Cohen JA, Mannarino AP, Iyengar S. Community treatment of posttraumatic stress disorder for children exposed to intimate partner violence: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011;165:16–21. doi: 10.1001/archpediatrics.2010.247.
    1. Cohen JA, Mannarino AP, Deblinger E. (2006). Treating trauma and traumatic grief in children and adolescents. Guilford Press.
    1. Cohen JA, Mannarino AP, Deblinger E. (2016). Treating trauma and traumatic grief in children and adolescents. Guilford Publications.
    1. Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50:217–226. doi: 10.1097/MLR.0b013e3182408812.
    1. Deblinger E, Cohen J, Mannarino A, Runyon M, Hanson R. TF-CBT PRACTICE fidelity Checklist. Unpublished instrument. Stratford: CARES Institute, RowanSOM; 2014.
    1. Deblinger E, Mannarino AP, Cohen JA, Runyon MK, Steer RA. Trauma-focused cognitive behavioral therapy for children: impact of the trauma narrative and treatment length. Depress Anxiety. 2011;28(1):67–75. doi: 10.1002/da.20744.
    1. de Haan AM, Boon AE, de Jong JTVM, Vermeiren RRJM. A meta-analytic review on treatment dropout in child and adolescent outpatient mental health care. Clin Psychol Rev. 2013;33(5):698–711. doi: 10.1016/j.cpr.2013.04.005.
    1. Diehle J, Opmeer B, Broer F, Mannarino AP, Lindauer RJL. Trauma-focused cognitive behavioral therapy or eye movement desensitization and reprocessing: what works in children with posttraumatic stress symptoms? A randomized controlled trial. Eur Child Adolesc Psychiatry. 2015;24(2):227–236. doi: 10.1007/s00787-014-0572-5.
    1. Dossett KW, Reid GJ. Defining dropout from children's mental health services: a novel need-based definition. J Child Fam Stud. 2020;29:2028–2038. doi: 10.1007/s10826-019-01631-1.
    1. Egeland KM, Skar A-MS, Endsjø M ... Aarons GA. Testing the leadership and organizational change for implementation (LOCI) intervention in Norwegian mental health clinics: a stepped-wedge cluster randomized design study protocol. Implement Sci. 2019;14(1). 10.1186/s13012-019-0873-7.
    1. Espeleta HC, Peer SO, Are F, Hanson R. (2021). Therapists' Perceived Competence in Trauma-Focused Cognitive Behavioral Therapy and Client Outcomes: Findings From a Community-Based Learning Collaborative. Child Maltreatment. 10.1177/10775595211003673
    1. Finkelhor D, Ormrod RK, Turner HA, Holt MA. Pathways to poly-victimization. Child Maltreat. 2009;14(4):316–329. doi: 10.1177/1077559509347012.
    1. Fritz CO, Morris PE, Richler JJ. Effect size estimates: current use, calculations, and interpretation. J Exp Psychol Gen. 2012;141(1):2. doi: 10.1037/a0024338.
    1. Green JG, McLaughlin KA, Berglund P, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC. Childhood adversities and adult psychopathology in the National Comorbidity Survey Replication (NCS-R) I: Associations with first onset of DSM-IV disorders. Arch Gen Psychiatry. 2010;62:113–123. doi: 10.1001/archgenpsychiatry.2009.186.
    1. Grol R, Wensing M. (2013). Effective implementation of change in healthcare: a systematic approach. Wiley online Library. In Grol R, Wensing M, Eccles M, Davis D. Improving Patient Care, 2nd Edition. The Implementation of Change in Health Care. Wiley Blackwell, BMJ Books.
    1. Hauber K, Boon A, Vermeiren R. Therapeutic Relationship and Dropout in High-Risk Adolescents' Intensive Group Psychotherapeutic Programme. Front Prychol. 2020. 10.3389/fpsyg.2020.533903
    1. Hunsley J, Aubry TD, Verstervelt CM, Vito D. Comparing therapist and client perspectives on reasons for psychotherapy termination. Psychother Theory Res Pract Train. 1999;36(4):380. doi: 10.1037/h0087802.
    1. International Society for Traumatic Stress Studies, ISTSS (2021). From
    1. Jaberghaderi N, Rezaei M, Kolivand M, Shokoohi A. Effectiveness of cognitive behavioral therapy and eye movement desensitization and reprocessing in child victims of domestic violence. Iran J Psychiatry. 2019;14(1):67–75.
    1. Jensen TK, Holt T, Ormhaug SM, Egeland K, Granly L, Hoaas LC, Wentzel-Larsen T. A randomized effectiveness study comparing trauma-focused cognitive behavioral therapy with therapy as usual for youth. J Clin Child Adolesc Psychol. 2014;43(3):356–369. doi: 10.1080/15374416.2013.822307.
    1. Kazdin AE, Mazurick JL, Siegel TC. Treatment outcome among children with externalizing disorder who terminate prematurely versus those who complete psychotherapy. J Am Acad Child Adolesc Psychiatry. 1994;33:549–557. doi: 10.1097/00004583-199405000-00013.
    1. Kar N. Cognitive behavioral therapy for the treatment of posttraumatic stress disorder: a review. Neuropsychiatr Dis Treat. 2011;7:167–181. doi: 10.2147/NDT.S10389.
    1. Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Williams DR. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197:378–385. doi: 10.1192/bjp.bp.110.080499.
    1. Knutsen ML, Sachser C, Holt T, Goldbeck L, Jensen TK. Trajectories and possible predictors of treatment outcome for youth receiving trauma-focused cognitive behavioral therapy. Psychol Trauma. 2020;12(4):336–346. doi: 10.1037/tra0000482.
    1. Lee E, Bowles K. (2020). Navigating treatment recommendation for PTSD: A rapid review. Int J Ment Health, 10.1080/00207411.2020.1781407
    1. Lee E, Faber J, Bowles K. A Review of Trauma Specific Treatments (TSTs) for Post-Traumatic Stress Disorder (PTSD) Clin Soc Work J. 2022;50:147–159. doi: 10.1007/s10615-021-00816-w.
    1. Lenz SA, Hollenbaugh MK. Meta-analysis of trauma-focused cognitive behavioral threapy for treating PTSD and Co-occurring depression among children and adolescents. Counseling Outcome Research and Evaluation. 2015;6(1):18–32. doi: 10.1177/2150137815573790.
    1. McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky A, Kessler RC. Childhood adversities and first onset of psychiatric disorders in a national sample of adolescents. Arch Gen Psychiatry. 2012;69:1151–1160. doi: 10.1001/archgenpsychiatry.2011.2277.
    1. Mendez JL, Carpenter JL, LaForett DR, et al. Parental engagement and barriers to participation in a community-based preventive intervention. Am J Community Psychol. 2009;44:1–14. doi: 10.1007/s10464-009-9252-x.
    1. Murray LK, Skavenski S, Kane JC, Bolton PA. Effectiveness of trauma-focused cognitive behavioral therapy among trauma-affected children in Lusaka, Zambia: a randomized clinical trial. JAM Pedriatr. 2015;169(8):761–769. doi: 10.1001/jamapediatrics.2015.0580.
    1. National Institute for Health and Care Excellence, NICE (2018). From
    1. Keeffe SO, Martin P, Goodyer IM, Kelvin R, Dubicka B. IMPACT Consortium, Midgley, N. Prognostic Implications for Adolescents With Depression Who Drop Out of Psychological Treatment During a Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2019;58(10):983–92.
    1. Ormhaug SM, Jensen TK. Investigating treatment characteristics and first-session relationship variables as predictors of dropout in the treatment of traumatized youth. Psychother Res. 2018;28(2):235–249. doi: 10.1080/10503307.2016.1189617.
    1. Pfeiffer E, Ormhaug SM, Tutus D, Holt T, Rosner R, Wentzel Larsen T, Jensen TK. Does the therapist matter? Therapist characteristics and their relation to outcome in trauma-focused cognitive behavioral therapy for children and adolescents. Eur J Psychotraumatol. 2020;11(1):1776048. doi: 10.1080/20008198.2020.1776048.
    1. Powell BJ, Waltz TJ, Chinman MJ, Kirchner J. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci. 2014;10(21). 10.1186/s13012-015-0209-1.
    1. Powell BJ, Fernandez ME, Williams NJ, Weiner BJ. (2019). Enhancing the Impact of Implementaiton Strategies in Helathcare: A Research Agenda. Fron. Public Health. 10.3389/fpubh.2019.00003
    1. R Core Team (2020). R: A language and environment for statistical computing. Vienna, Austria.
    1. Racine N, Hartwick C, Collin-Vèzina D, Madigan S. Telemental health for child trauma treatment during and post-COVID-19: Limitations and considerations. Child Abuse Negl. 2020;101. 10.1016/j.chiabu.2020.104698.
    1. Sachser C, Berliner L, Holt T, et al. International development and psychometric properties of the Child and Adolescent Trauma Screen (CATS). J Affect Disord. 2017;210:189–95. 10.1016/j.jad.2016.12.040-DOI-PubMed.
    1. Sachser C, Berliner L, Risch E, et al. The child and Adolescent Trauma Screen 2 (CATS-2) – validation of an instrument to measure DSM-5 and ICD-11 PTSD and complex PTSD in children and Adolescents. Eur J Psychotraumatol. 2022;13(2):2105580. doi: 10.1080/20008066.2022.2105580.
    1. Simmons C, Meiser-Stedman R, Baily H, Beazley P. A meta-analysis of dropout from evidence-based psychological treatment for posttraumatic stress disorder (PTSD) in children and young people. Eur J Psychotraumatol. 2021;12(1):1947570. doi: 10.1080/20008198.2021.1947570.
    1. Skar A-MS, Braathu N, Peters N ... Egeland KM. A stepped-wedge randomized trial investigating the effect of the Leadership and Organizational Change for Implementation (LOCI) intervention on implementation and transformational leadership, and implementation climate. BMC Health Serv Res. 2022;22(298).
    1. Szumilas M. Explaining odds rations. J Can Acad Child Adolesc Psychiatry. 2010;19(3):227–229.
    1. Teicher MH, Samson JA. Annual research review: enduring neurobiological effects of childhood abuse and neglect. J Child Psychol Psychiatry. 2016;57(3):241–266. doi: 10.1111/jcpp.12507.
    1. Trickey D, Siddaway AP, Meiser-Stedman R, Serpell L, Field AP. A meta-analysis of risk factors for posttraumatic stress disorder in children and adolescents. Clin Psychol Rev. 2012;32(2):122–138. doi: 10.1016/j.cpr.2011.12.001.
    1. Varker T, Kartal D, Watson L, Hinton M. Defining response and non-response to post-traumatic stress disorder treatments: A systematic review. Clin Psychol Sci Pract. 2020;27(4).
    1. Wachen JS, Dondanville KA, Evans WR, Morris K, Cole A. Adjusting the Timeframe of Evidence-Based Therapies for PTSD-Massed Treatments. Curr Treat Options Psychiatry. 2019;6:107–118. doi: 10.1007/s40501-019-00169-9.
    1. Wamser-Nanney R, Steinzor CE. Factors related to attrition from trauma-focused cognitive behavioral therapy. Child Abuse Negl. 2017;66:73–83. doi: 10.1016/j.chiabu.2016.11.031.
    1. Wamser-Nanney R, Scheeringa M, Weems CF. Early treatment response in children and adolescents receiving CBT for trauma. J Pediatr Psychol. 2016;41(1):128–137. doi: 10.1093/jpepsy/jsu096.
    1. Weisz JR, Kuppens S, Eckshtain D, Ugueto AM, Hawley KM, Jensen- Doss A. Do Evidence-Based Youth Psychotherapies Outperform Usual Clinical Care? A Multilevel Meta-Analysis. JAMA Psychiatry. 2013;70(7).
    1. Wells JE, Browne MO, Aguilar-Gaxiola S, Kesller RC. Drop out from out-patient mental healthcare in the World Health Organization's World Mental Health Survey initiative. Br J Psychiatry. 2013;2020:42–49. doi: 10.1192/bjp.bp.112.113134.
    1. Wasserstein RL, Schirm AL, Lazar NA. Moving to a world beyond “p< 0.05”. Am Stat. 2019;73(S1):1–19. doi: 10.1080/00031305.2019.1583913.
    1. Wong CA, Cummings GG, Ducharme L. The relationship between nursing leadership and patient outcomes: a systematic review update. J Nurs Manag. 2013;5:709–724. doi: 10.1111/jonm.12116.
    1. Wright I, Mughal F, Bowers G, Meiser-Stedman R. Dropout from randomised controlled trials of psychological treatments for depression in children and youth: a systematic review and meta-analyses. J Affect Disord. 2021;281:880–890. doi: 10.1016/j.jad.2020.11.039.
    1. Yasinski C, Hayes AM, Alpert E, McCauley T, Ready CB, Webb C, Deblinger E. Treatment processes and demographic variables as predictors of dropout from trauma-focused cognitive behavioral therapy (TF-CBT) for youth. Behav Res Ther. 2018;107:10–18. doi: 10.1016/j.brat.2018.05.008.
    1. Ziliak S, McCloskey D. (2008). The cult of statistical significance: How the standard error costs us jobs, justice, and lives. University of Michigan Press.

Source: PubMed

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