Antibody persistence and immune memory 4 years post-vaccination with combined hepatitis A and B vaccine in adults aged over 40 years
Roman Chlibek, Frank von Sonnenburg, Pierre Van Damme, Jan Smetana, Petr Tichy, Bhavyashree Gunapalaiah, Maarten Leyssen, Jeanne-Marie Jacquet, Roman Chlibek, Frank von Sonnenburg, Pierre Van Damme, Jan Smetana, Petr Tichy, Bhavyashree Gunapalaiah, Maarten Leyssen, Jeanne-Marie Jacquet
Abstract
Persistence of immune response was assessed in adults aged >40 years (N = 596) following primary vaccination with combined hepatitis A/B vaccine or concomitant monovalent hepatitis A and B vaccines. Anti-hepatitis A virus antibody responses persisted for at least 4 years regardless of the vaccine used, with anti-hepatitis B surface antibody responses higher and more sustained in subjects who received the combined hepatitis A/B vaccine. Response rates to an additional dose of the same vaccine(s) used for priming were high.
Trial registration: ClinicalTrials.gov NCT00603252 NCT00684671.
© 2011 International Society of Travel Medicine.
Source: PubMed