Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: A respiratory virus snapshot

Sophie Amrane, Hervé Tissot-Dupont, Barbara Doudier, Carole Eldin, Marie Hocquart, Morgane Mailhe, Pierre Dudouet, Etienne Ormières, Lucie Ailhaud, Philippe Parola, Jean-Christophe Lagier, Philippe Brouqui, Christine Zandotti, Laetitia Ninove, Léa Luciani, Céline Boschi, Bernard La Scola, Didier Raoult, Matthieu Million, Philippe Colson, Philippe Gautret, Sophie Amrane, Hervé Tissot-Dupont, Barbara Doudier, Carole Eldin, Marie Hocquart, Morgane Mailhe, Pierre Dudouet, Etienne Ormières, Lucie Ailhaud, Philippe Parola, Jean-Christophe Lagier, Philippe Brouqui, Christine Zandotti, Laetitia Ninove, Léa Luciani, Céline Boschi, Bernard La Scola, Didier Raoult, Matthieu Million, Philippe Colson, Philippe Gautret

Abstract

Background: Rapid virological diagnosis is needed to limit the length of isolation for suspected COVID-19 cases.

Method: We managed the first 280 patients suspected to have COVID-19 through a rapid care circuit and virological diagnosis in our infectious disease reference hospital in Marseille, France. Rapid viral detection was performed on sputum and nasopharyngeal samples.

Results: Over our study period, no SARS-CoV-2 was detected. Results were obtained within approximately 3 h of the arrival of patient samples at the laboratory. Other viral infections were identified in 49% of the patients, with most common pathogens being influenza A and B viruses, rhinovirus, metapneumovirus and common coronaviruses, notably HKU1 and NL63.

Conclusion: Early recognition of COVID-19 is critical to isolate confirmed cases and prevent further transmission. Early rule-out of COVID-19 allows public health containment measures to be adjusted by reducing the time spent in isolation.

Keywords: COVID-19; Coronaviruses; Epidemic; Influenza; SARS-CoV-2; Travel.

Conflict of interest statement

None to declare.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Figures

Fig. 1
Fig. 1
Definition of suspected COVID-19 cases overtime in France.
Fig. 2
Fig. 2
Numbers of patients by date of consultation.
Fig. 3
Fig. 3
Proportion of each virus among patients testing positive according to region of exposure.

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Source: PubMed

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