A roentgenographic assessment of regenerative efficacy of bioactive Gengigel(®) in conjunction with amnion membrane in grade II furcation defect

S Harveen Kalra, Chandni Monga, K Heena Kalra, S Harshneet Kalra, S Harveen Kalra, Chandni Monga, K Heena Kalra, S Harshneet Kalra

Abstract

Background: Nowadays, techniques are being developed to guide and instruct the specialized cellular components of the periodontium to participate in the regenerative process. This approach of reconstruction makes use of understanding of the development of the periodontium and the cellular processes that are involved. Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration, and proliferation. Hence, its administration to periodontal wound sites could achieve comparable beneficial effects in periodontal tissue regeneration. Hence, the purpose of the present case report was to assess roentgenographically, the regenerative capacity of Gengigel(®) in conjunction with bioactive amnion guided tissue regeneration (GTR) membrane in a patient with Grade II furcation defect.

Case presentation: A patient complained of bleeding gums from the lower back tooth region, reportedly found Grade II furcation in the lower right mandibular first molar. After Phase, I therapy, Gengigel(®) along with bioactive amnion membrane was placed in the furcation area during the surgical phase. Roentgenographic assessment was done at 4 months and 6 months postoperatively. It resulted in complete defect-fill and loss of radiolucency at 6 months.

Conclusion: Surgical placement of Gengigel(®) along with amnion membrane in the furcation defect can significantly improve the periodontal defect morphology.

Keywords: 0.2% hyaluronic acid; Bioactive amnion membrane; Gengigel®; furcation.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Preoperative radiograph showing furcation defect having ~ 3 mm vertical dimension (a and b) (Also, arrow showing large intrabony defect on the mesial of right mandibular first molar)
Figure 2
Figure 2
Crevicular incision
Figure 3
Figure 3
Exposure of defect site after debridement
Figure 4
Figure 4
Intra-operative furcation defect measurement using Q2N Naber's probe having horizontal dimension ~ 3 mm (Grade II furcation)
Figure 5
Figure 5
Application of Gengigel® (0.2% Hyaluronic acid) in the defect site after presuturing
Figure 6
Figure 6
Placement of bioactive amnion membrane to cover the Gengigel®
Figure 7
Figure 7
4 months postoperative radiograph showing reduction furcation defect having ~ 1.5 mm vertical dimension (a1 and b1) (Also, arrow showing defect fill mesial to the right mandibular molar)
Figure 8
Figure 8
Six months postoperative radiograph showing almost complete furcation defect fill having vertical residual radiolucency of
All figures (8)

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