Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Sara Akerström, Mehrdad Mousavi-Jazi, Jonas Klingström, Mikael Leijon, Ake Lundkvist, Ali Mirazimi, Sara Akerström, Mehrdad Mousavi-Jazi, Jonas Klingström, Mikael Leijon, Ake Lundkvist, Ali Mirazimi
Abstract
Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.
Figures
Source: PubMed