A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova, Helen C Su, COVID Human Genetic Effort, Laurent Abel, Alessandro Aiuti, Saleh Almuhsen, Andres Augusto Arias, Paul Bastard, Catherine Biggs, Dusan Bogunovic, Bertrand Boisson, Stephanie Boisson-Dupuis, Alexandre Bolze, Anastasia Bondarenko, Aziz Bousfiha, Petter Brodin, Jacinta Bustamante, Manish Butte, Giorgio Casari, Michael Ciancanelli, Aurelie Cobat, Antonio Condino-Neto, Megan Cooper, Clifton Dalgard, Sara Espinosa, Hagit Feldman, Jacques Fellay, Jose Luis Franco, David Hagin, Yuval Itan, Emmanuelle Jouanguy, Carrie Lucas, Davood Mansouri, Isabelle Meyts, Joshua Milner, Trine Mogensen, Tomohiro Morio, Lisa Ng, Luigi D Notarangelo, Satoshi Okada, Tayfun Ozcelik, Pere Soler Palacín, Anna Planas, Carolina Prando, Anne Puel, Aurora Pujol, Claire Redin, Laurent Renia, Jose Carlos Rodriguez Gallego, Lluis Quintana-Murci, Vanessa Sancho-Shimizu, Vijay Sankaran, Mikko R J Seppänen, Mohammad Shahrooei, Andrew Snow, András Spaan, Stuart Tangye, Jordi Perez Tur, Stuart Turvey, Donald C Vinh, Horst von Bernuth, Xiaochuan Wang, Pawel Zawadzki, Qian Zhang, Shenying Zhang, Jean-Laurent Casanova, Helen C Su, COVID Human Genetic Effort, Laurent Abel, Alessandro Aiuti, Saleh Almuhsen, Andres Augusto Arias, Paul Bastard, Catherine Biggs, Dusan Bogunovic, Bertrand Boisson, Stephanie Boisson-Dupuis, Alexandre Bolze, Anastasia Bondarenko, Aziz Bousfiha, Petter Brodin, Jacinta Bustamante, Manish Butte, Giorgio Casari, Michael Ciancanelli, Aurelie Cobat, Antonio Condino-Neto, Megan Cooper, Clifton Dalgard, Sara Espinosa, Hagit Feldman, Jacques Fellay, Jose Luis Franco, David Hagin, Yuval Itan, Emmanuelle Jouanguy, Carrie Lucas, Davood Mansouri, Isabelle Meyts, Joshua Milner, Trine Mogensen, Tomohiro Morio, Lisa Ng, Luigi D Notarangelo, Satoshi Okada, Tayfun Ozcelik, Pere Soler Palacín, Anna Planas, Carolina Prando, Anne Puel, Aurora Pujol, Claire Redin, Laurent Renia, Jose Carlos Rodriguez Gallego, Lluis Quintana-Murci, Vanessa Sancho-Shimizu, Vijay Sankaran, Mikko R J Seppänen, Mohammad Shahrooei, Andrew Snow, András Spaan, Stuart Tangye, Jordi Perez Tur, Stuart Turvey, Donald C Vinh, Horst von Bernuth, Xiaochuan Wang, Pawel Zawadzki, Qian Zhang, Shenying Zhang

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

Conflict of interest statement

Declaration of Interests Helen Su holds Adjunct Faculty position in the Department of Pathology and Laboratory Medicine, University of Pennsylvania.

Copyright © 2020 Elsevier Inc. All rights reserved.

Figures

Figure 1
Figure 1
Monogenic Causes of Susceptibility or Resistance to SARS-CoV-2 Infection In the naive general population (black), a proportion of people become symptomatic (purple) when infected. Severe cases (red) tend to occur in the elderly or in those patients having co-morbidities. However, rare “idiopathic” severe cases can occur in the young without co-morbidities, and these are hypothesized to represent patients with monogenic causes. A proportion of people remain asymptomatic (blue) when infected. In some instances, these may be people who remain resistant to infection (orange), who can be identified by their remaining seronegative despite heavy or repeated exposures to the virus. Created with BioRender.

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