Acute Coronary Syndrome Genetic Study

Inclusion Criteria:

• Written informed consent has been provided.
• Contact Order Form has been provided.
• Aged 18 years or older.

• Diagnosis of STEMI, NSTEMI or UA using the following definitions:

  1. Criteria for STEMI diagnosis:

     1. History of chest pain/discomfort and
     2. Persistent ST-segment elevation (> 30 min) of ≥ 0.1 mV in 2 or more contiguous ECG leads or presumed new left bundle branch block (LBBB) on admission and
     3. Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit.

  2. Criteria for NSTEMI diagnosis:

     1. History of chest pain/discomfort and
     2. Lack of persistent ST-segment elevation, LBBB or intraventricular conduction disturbances and
     3. Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit.

  3. Criteria for Unstable Angina diagnosis:

     1. Symptoms of angina at rest or on minimal exercise and
     2. At least 0.5mm ST deviation in at least 2 leads and
     3. No increase in biomarkers of necrosis
     4. OR objective evidence of ischaemia by non-invasive imaging OR significant coronary stenosis as determined by the treating physician at angiography if this is standard practice in study site.
• Hospitalized within 48 hours of onset of symptoms.

Exclusion Criteria:

Patients will not be eligible to participate if any of the following exclusion criteria are present:

• UA, STEMI and NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI.
• UA, STEMI and NSTEMI occurring in patients already hospitalized for other reasons.
• Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances).
• Presence of serious/severe co-morbidities in the opinion of the investigator which may limit short term (i.e. 6 month) life expectancy.
• Current participation in a randomised interventional clinical trial.