Biological Aging of Skeletal Muscles in Humans (BioAge)
Biological Aging of Skeletal Muscles in Humans, a Monocentric, Prospective Study
Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. Sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more.
However, strong inter-individual variations of this prevalence of sarcopenia exists. The key issue is to understand why the biological aging of the skeletal muscle is so different between people.
In this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.
調査の概要
詳細な説明
Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to the aging contributes to the lack of autonomy and dependence, but also to an increase of the mortality risks. Sarcopenia is also a prevalent condition, because it is detected in 13-24% of 60 years old, and 50% of 80 years old and more.
However, strong inter-individual variations of this prevalence of sarcopenia exists. Some elderly (60 years old) reveal a biological aging of 80 years old, whereas 60 years old people reveal a biological aging of 60 years old. The key issue is to understand why the biological aging of the skeletal muscle is so different between people.
Previous sarcopenia studies in Humans did not really focus on chronological aging, they were all based on a comparison between young and old people. No study considered inter-individual modifications (biological aging) in sarcopenia. Furthermore, few studies were associated in the same study to "omic", histological, and epigenetic data, to obtain integrated point of view of Human Sarcopenia.
In this study, mechanisms involved in biological aging of the skeletal muscle in aging people (same chronological age) will be specified.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Saint Etienne、フランス、42100
- CHU Saint Etienne
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Belonging to the Proof cohort
- Between 80 and 83 years old
- Informed consent signed
- Genetic analyses consent signed
- Subject affiliated or entitled to a social security scheme
Exclusion Criteria:
- Anti coagulative treatment
- Severe obesity (>35)
- All chronic pathology requiring a treatment
- Severe renal insufficiency (discovery less than 6 months)
- Abnormal coagulation appraisal
- Allergy to local anesthetics
- Installation of a prosthetic hip and / or knee in the last six months
- Senile dementia
- Refusal of genetic study
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
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Proof cohort : muscular assessment
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Clinical examination, blood appraisal, urinary collection, MVC, checking muscle functional skills and muscular biopsy will be performed.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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The area of type IIA fibers called vastus lateralis.
時間枠：Day 15
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The primary endpoint is the cross sectional area (measured in µm2) of type IIA fibers from the vastus lateralis muscle biopsies.
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Day 15
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協力者と研究者
協力者
捜査官
- 主任研究者：FEASSON Léonard, MD、CHU Saint Etienne
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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