Abuse and Addiction in ICU
2021年8月18日 更新者：Jinwoo Lee、Seoul National University Hospital
Effect of Recent Alcohol, Smoking and Psychotropic Drug Use on Delirium in ICU
Investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (ICU) admission on incidence of delirium and sedation requirements.
Study design: A prospective observational study, in a medical ICU of a tertiary university hospital.
Methods: For all new ICU admissions, a 1-page questionnaire including Alcohol Use Disorders Identification Test (AUDIT-C), smoking history and prior medication use was given to the patient or closest family members.
Delirium was assessed by trained ICU nurses using Intensive Care Delirium Screening Checklist and Richmond Agitation-Sedation Scale.
調査の概要
研究の種類
観察的
入学 (予想される)
200
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Seoul、大韓民国、110744
- Seoul National University Hospital
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年歳以上 (大人、高齢者)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
サンプリング方法
非確率サンプル
調査対象母集団
For all new ICU admissions above age of 18 years, except for those who fulfill exclusion criteria
説明
Inclusion Criteria:
- Patients who are older than 18 years of age
- New patients admitted to medical ICU for the 1st time during their stay in hospital
Exclusion Criteria:
- Had history of stroke or other primary neurologic disease
- GCS ≤ 8 prior to ICU admission
- Transferred from other ICU (except for emergency ICU stay which is limited to less than 36 hours)
- Not registered within 24 hours after admission
- Refused to participate
- If comatous state persists
- Delirium assessment is not possible due to newly developed neurologic disease, such as cerebral infarction
- Medical ICU stay less than 24 hours
- Readmission to medical ICU
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：コホート
- 時間の展望：見込みのある
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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AUDIT-C > 4
Significant alcohol use within 1 year prior to ICU admission (AUDIT-C>4)
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including AUDIT-C about his/her alcohol behavior during last year and will be categorized into two groups: Those with AUDIT-C>4 versus AUDIT-C of 4 or below.
他の名前：
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AUDIT-C <=4
No significant alcohol use within 1 year prior to ICU admission (AUDIT-C: equal or less than 4)
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including AUDIT-C about his/her alcohol behavior during last year and will be categorized into two groups: Those with AUDIT-C>4 versus AUDIT-C of 4 or below.
他の名前：
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Smoking history positive last year
Who smoke cigarette within 1-year prior to ICU admission
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including smoking history during last year and will be categorized into two groups: Current smoker versus ex- or never smoker (we also recorded smoking pack-years to distinguish heavy smokers)
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Smoking history negative last year
Who did not smoke cigarette within 1-year prior to ICU admission
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including smoking history during last year and will be categorized into two groups: Current smoker versus ex- or never smoker (we also recorded smoking pack-years to distinguish heavy smokers)
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Prior psychotropic medication use - yes
Who used psychotropic medication within 1-year prior to ICU admission
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including psychotropic medication use prior admission to ICU and will be categorized into two groups: Those who use psychotropic medication versus those who do not use psychotropic medication.
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Prior psychotropic medication use - no
Who did not use psychotropic medication within 1-year prior to ICU admission
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Patients or their proxy/closest family member(s) undergo a comprehensive questionnaire including psychotropic medication use prior admission to ICU and will be categorized into two groups: Those who use psychotropic medication versus those who do not use psychotropic medication.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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Delirium during ICU stay
時間枠：From date of ICU admission until the date of ICU discharge, whichever came first, assessed up to 3 months
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From date of ICU admission until the date of ICU discharge, whichever came first, assessed up to 3 months
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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ICU length of stay
時間枠：From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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Mortality
時間枠：From date of ICU admission until the date of death, assessed up to 3 months
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Death in MICU
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From date of ICU admission until the date of death, assessed up to 3 months
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Maximal doses of dexmedetomidine
時間枠：From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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Cumulative dose of dexmedetomidine
時間枠：From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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Cumulative dose of dexmedetomidine during the patient's MICU stay
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From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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Cumulative dose of midazolam
時間枠：From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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Cumulative dose of midazolam during the patient's MICU stay
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From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- スタディチェア：Jinwoo Lee, Professor、Seoul National University Hospital
- 主任研究者：Jungsil Lee, M.D.、Seoul National University Hospital
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始
2016年3月1日
一次修了 (予想される)
2022年12月1日
研究の完了 (予想される)
2022年12月1日
試験登録日
最初に提出
2016年10月11日
QC基準を満たした最初の提出物
2016年10月30日
最初の投稿 (見積もり)
2016年11月1日
学習記録の更新
投稿された最後の更新 (実際)
2021年8月20日
QC基準を満たした最後の更新が送信されました
2021年8月18日
最終確認日
2021年8月1日
詳しくは
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