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Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

2017年1月24日 更新者：Truls Raastad、Norwegian School of Sport Sciences

Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

調査の概要

状態

完了

条件

介入・治療

詳細な説明

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

研究の種類

介入

入学 (実際)

66

段階

  • 適用できない

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究場所

  • ノルウェー
      • Oslo、ノルウェー、0863
        • Norwegian School of Sport Sciences

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

20年歳以上 (大人、高齢者)

健康ボランティアの受け入れ

はい

受講資格のある性別

全て

説明

Inclusion Criteria:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Exclusion Criteria:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

  • 主な目的：基礎科学
  • 割り当て：ランダム化
  • 介入モデル：並列代入
  • マスキング：4倍

武器と介入

参加者グループ / アーム
介入・治療
プラセボコンパレーター：Milk supplementation
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
他の：筋力トレーニング
ダイエットサプリメント：牛乳
実験的：Native whey
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.
他の：筋力トレーニング
ダイエットサプリメント：ネイティブホエイ

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
Lean mass
時間枠：Before the training intervention
Measured by whole body dual x-ray absorptiometry (DXA)
Before the training intervention
Lean mass
時間枠：After 11-12 weeks of strength training
Measured by whole body dual x-ray absorptiometry (DXA)
After 11-12 weeks of strength training

二次結果の測定

結果測定
メジャーの説明
時間枠
Thigh muscle cross sectional area
時間枠：Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Thigh muscle cross sectional area
時間枠：After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Pectoralis muscle cross sectional area
時間枠：Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Pectoralis muscle cross sectional area
時間枠：After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Arm cross sectional area
時間枠：Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Arm cross sectional area
時間枠：After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Thickness of the lateral vasti
時間枠：Before the training intervention
Measured by ultrasound
Before the training intervention
Thickness of the lateral vasti
時間枠：After 11-12 weeks of strength training
Measured by ultrasound
After 11-12 weeks of strength training
1 repetition maximum in leg press
時間枠：Before the training intervention
Before the training intervention
1 repetition maximum in leg press
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training
1 repetition maximum in bench press
時間枠：Before the training intervention
Before the training intervention
1 repetition maximum in bench press
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
時間枠：30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Plasma amino acid concentration
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Plasma amino acid concentration
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Muscle force generating capacity change from baseline
時間枠：15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Muscle force generating capacity change from baseline
時間枠：15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum glucose
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum glucose
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum insulin
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum insulin
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum urea
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum urea
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum creatine kinase
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum creatine kinase
時間枠：60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 6 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 6 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 8 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 8 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1b mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1b mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 4 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 4 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 10 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 10 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 17D mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 17D mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Atrogin-1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Atrogin-1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
時間枠：2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
時間枠：30 min after exercise and protein intake, after 11-12 weeks of strength training
30 min after exercise and protein intake, after 11-12 weeks of strength training
Fasting cholesterol (only in elderly)
時間枠：Before training intervention
Before training intervention
Fasting cholesterol (only in elderly)
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting triglycerides (only in elderly)
時間枠：Before training intervention
Before training intervention
Fasting triglycerides (only in elderly)
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting LDL (only in elderly)
時間枠：Before training intervention
Before training intervention
Fasting LDL (only in elderly)
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting HDL (only in elderly)
時間枠：Before training intervention
Before training intervention
Fasting HDL (only in elderly)
時間枠：After 11-12 weeks of strength training
After 11-12 weeks of strength training

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

Norwegian School of Sport Sciences

協力者

The Research Council of Norway
Tine

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始

2014年8月1日

一次修了 (実際)

2015年6月1日

研究の完了 (実際)

2016年11月1日

試験登録日

最初に提出

2017年1月19日

QC基準を満たした最初の提出物

2017年1月24日

最初の投稿 (見積もり)

2017年1月27日

学習記録の更新

投稿された最後の更新 (見積もり)

2017年1月27日

QC基準を満たした最後の更新が送信されました

2017年1月24日

最終確認日

2017年1月1日

詳しくは

本研究に関する用語

その他の研究ID番号

  • Tine 12wk

個々の参加者データ (IPD) の計画

個々の参加者データ (IPD) を共有する予定はありますか?

未定

この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。

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