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Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

24 janvier 2017 mis à jour par: Truls Raastad, Norwegian School of Sport Sciences

Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

Aperçu de l'étude

Description détaillée

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

Type d'étude

Interventionnel

Inscription (Réel)

66

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Lieux d'étude

      • Oslo, Norvège, 0863
        • Norwegian School of Sport Sciences

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

20 ans et plus (Adulte, Adulte plus âgé)

Accepte les volontaires sains

Oui

Sexes éligibles pour l'étude

Tout

La description

Inclusion Criteria:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Exclusion Criteria:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: Science basique
  • Répartition: Randomisé
  • Modèle interventionnel: Affectation parallèle
  • Masquage: Quadruple

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Comparateur placebo: Milk supplementation
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
Expérimental: Native whey
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
Lean mass
Délai: Before the training intervention
Measured by whole body dual x-ray absorptiometry (DXA)
Before the training intervention
Lean mass
Délai: After 11-12 weeks of strength training
Measured by whole body dual x-ray absorptiometry (DXA)
After 11-12 weeks of strength training

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
Thigh muscle cross sectional area
Délai: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Thigh muscle cross sectional area
Délai: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Pectoralis muscle cross sectional area
Délai: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Pectoralis muscle cross sectional area
Délai: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Arm cross sectional area
Délai: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Arm cross sectional area
Délai: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Thickness of the lateral vasti
Délai: Before the training intervention
Measured by ultrasound
Before the training intervention
Thickness of the lateral vasti
Délai: After 11-12 weeks of strength training
Measured by ultrasound
After 11-12 weeks of strength training
1 repetition maximum in leg press
Délai: Before the training intervention
Before the training intervention
1 repetition maximum in leg press
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training
1 repetition maximum in bench press
Délai: Before the training intervention
Before the training intervention
1 repetition maximum in bench press
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Délai: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Plasma amino acid concentration
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Plasma amino acid concentration
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Muscle force generating capacity change from baseline
Délai: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Muscle force generating capacity change from baseline
Délai: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum glucose
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum glucose
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum insulin
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum insulin
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum urea
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum urea
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum creatine kinase
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum creatine kinase
Délai: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 6 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 6 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 8 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 8 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1b mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1b mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 4 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 4 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 10 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 10 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 17D mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 17D mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Atrogin-1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Atrogin-1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Délai: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Délai: 30 min after exercise and protein intake, after 11-12 weeks of strength training
30 min after exercise and protein intake, after 11-12 weeks of strength training
Fasting cholesterol (only in elderly)
Délai: Before training intervention
Before training intervention
Fasting cholesterol (only in elderly)
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting triglycerides (only in elderly)
Délai: Before training intervention
Before training intervention
Fasting triglycerides (only in elderly)
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting LDL (only in elderly)
Délai: Before training intervention
Before training intervention
Fasting LDL (only in elderly)
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting HDL (only in elderly)
Délai: Before training intervention
Before training intervention
Fasting HDL (only in elderly)
Délai: After 11-12 weeks of strength training
After 11-12 weeks of strength training

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude

1 août 2014

Achèvement primaire (Réel)

1 juin 2015

Achèvement de l'étude (Réel)

1 novembre 2016

Dates d'inscription aux études

Première soumission

19 janvier 2017

Première soumission répondant aux critères de contrôle qualité

24 janvier 2017

Première publication (Estimation)

27 janvier 2017

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Estimation)

27 janvier 2017

Dernière mise à jour soumise répondant aux critères de contrôle qualité

24 janvier 2017

Dernière vérification

1 janvier 2017

Plus d'information

Termes liés à cette étude

Autres numéros d'identification d'étude

  • Tine 12wk

Plan pour les données individuelles des participants (IPD)

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INDÉCIS

Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .

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