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Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

24. ledna 2017 aktualizováno: Truls Raastad, Norwegian School of Sport Sciences

Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

Přehled studie

Postavení

Dokončeno

Podmínky

Intervence / Léčba

Detailní popis

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

Typ studie

Intervenční

Zápis (Aktuální)

66

Fáze

  • Nelze použít

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

  • Norsko
      • Oslo, Norsko, 0863
        • Norwegian School of Sport Sciences

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

20 let a starší (Dospělý, Starší dospělý)

Přijímá zdravé dobrovolníky

Ano

Pohlaví způsobilá ke studiu

Všechno

Popis

Inclusion Criteria:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Exclusion Criteria:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

  • Primární účel: Základní věda
  • Přidělení: Randomizované
  • Intervenční model: Paralelní přiřazení
  • Maskování: Čtyřnásobek

Zbraně a zásahy

Skupina účastníků / Arm
Intervence / Léčba
Komparátor placeba: Milk supplementation
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
Jiný: Silový trénink
Doplněk stravy: Mléko
Experimentální: Native whey
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.
Jiný: Silový trénink
Doplněk stravy: Nativní syrovátka

Co je měření studie?

Primární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Lean mass
Časové okno: Before the training intervention
Measured by whole body dual x-ray absorptiometry (DXA)
Before the training intervention
Lean mass
Časové okno: After 11-12 weeks of strength training
Measured by whole body dual x-ray absorptiometry (DXA)
After 11-12 weeks of strength training

Sekundární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Thigh muscle cross sectional area
Časové okno: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Thigh muscle cross sectional area
Časové okno: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Pectoralis muscle cross sectional area
Časové okno: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Pectoralis muscle cross sectional area
Časové okno: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Arm cross sectional area
Časové okno: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Arm cross sectional area
Časové okno: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Thickness of the lateral vasti
Časové okno: Before the training intervention
Measured by ultrasound
Before the training intervention
Thickness of the lateral vasti
Časové okno: After 11-12 weeks of strength training
Measured by ultrasound
After 11-12 weeks of strength training
1 repetition maximum in leg press
Časové okno: Before the training intervention
Before the training intervention
1 repetition maximum in leg press
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training
1 repetition maximum in bench press
Časové okno: Before the training intervention
Before the training intervention
1 repetition maximum in bench press
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Časové okno: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Plasma amino acid concentration
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Plasma amino acid concentration
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Muscle force generating capacity change from baseline
Časové okno: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Muscle force generating capacity change from baseline
Časové okno: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum glucose
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum glucose
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum insulin
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum insulin
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum urea
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum urea
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum creatine kinase
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum creatine kinase
Časové okno: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 6 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 6 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 8 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 8 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1b mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1b mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 4 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 4 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 10 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 10 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 17D mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 17D mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Atrogin-1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Atrogin-1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Časové okno: 30 min after exercise and protein intake, after 11-12 weeks of strength training
30 min after exercise and protein intake, after 11-12 weeks of strength training
Fasting cholesterol (only in elderly)
Časové okno: Before training intervention
Before training intervention
Fasting cholesterol (only in elderly)
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting triglycerides (only in elderly)
Časové okno: Before training intervention
Before training intervention
Fasting triglycerides (only in elderly)
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting LDL (only in elderly)
Časové okno: Before training intervention
Before training intervention
Fasting LDL (only in elderly)
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting HDL (only in elderly)
Časové okno: Before training intervention
Before training intervention
Fasting HDL (only in elderly)
Časové okno: After 11-12 weeks of strength training
After 11-12 weeks of strength training

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

Norwegian School of Sport Sciences

Spolupracovníci

The Research Council of Norway
Tine

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia

1. srpna 2014

Primární dokončení (Aktuální)

1. června 2015

Dokončení studie (Aktuální)

1. listopadu 2016

Termíny zápisu do studia

První předloženo

19. ledna 2017

První předloženo, které splnilo kritéria kontroly kvality

24. ledna 2017

První zveřejněno (Odhad)

27. ledna 2017

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Odhad)

27. ledna 2017

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

24. ledna 2017

Naposledy ověřeno

1. ledna 2017

Více informací

Termíny související s touto studií

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