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Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

24 de janeiro de 2017 atualizado por: Truls Raastad, Norwegian School of Sport Sciences

Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

Visão geral do estudo

Descrição detalhada

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

Tipo de estudo

Intervencional

Inscrição (Real)

66

Estágio

  • Não aplicável

Contactos e Locais

Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.

Locais de estudo

      • Oslo, Noruega, 0863
        • Norwegian School of Sport Sciences

Critérios de participação

Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.

Critérios de elegibilidade

Idades elegíveis para estudo

20 anos e mais velhos (Adulto, Adulto mais velho)

Aceita Voluntários Saudáveis

Sim

Gêneros Elegíveis para o Estudo

Tudo

Descrição

Inclusion Criteria:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Exclusion Criteria:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Plano de estudo

Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.

Como o estudo é projetado?

Detalhes do projeto

  • Finalidade Principal: Ciência básica
  • Alocação: Randomizado
  • Modelo Intervencional: Atribuição Paralela
  • Mascaramento: Quadruplicar

Armas e Intervenções

Grupo de Participantes / Braço
Intervenção / Tratamento
Comparador de Placebo: Milk supplementation
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
Experimental: Native whey
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.

O que o estudo está medindo?

Medidas de resultados primários

Medida de resultado
Descrição da medida
Prazo
Lean mass
Prazo: Before the training intervention
Measured by whole body dual x-ray absorptiometry (DXA)
Before the training intervention
Lean mass
Prazo: After 11-12 weeks of strength training
Measured by whole body dual x-ray absorptiometry (DXA)
After 11-12 weeks of strength training

Medidas de resultados secundários

Medida de resultado
Descrição da medida
Prazo
Thigh muscle cross sectional area
Prazo: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Thigh muscle cross sectional area
Prazo: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Pectoralis muscle cross sectional area
Prazo: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Pectoralis muscle cross sectional area
Prazo: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Arm cross sectional area
Prazo: Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Arm cross sectional area
Prazo: After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Thickness of the lateral vasti
Prazo: Before the training intervention
Measured by ultrasound
Before the training intervention
Thickness of the lateral vasti
Prazo: After 11-12 weeks of strength training
Measured by ultrasound
After 11-12 weeks of strength training
1 repetition maximum in leg press
Prazo: Before the training intervention
Before the training intervention
1 repetition maximum in leg press
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training
1 repetition maximum in bench press
Prazo: Before the training intervention
Before the training intervention
1 repetition maximum in bench press
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
Prazo: 30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Plasma amino acid concentration
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Plasma amino acid concentration
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Muscle force generating capacity change from baseline
Prazo: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Muscle force generating capacity change from baseline
Prazo: 15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum glucose
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum glucose
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum insulin
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum insulin
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum urea
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum urea
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum creatine kinase
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum creatine kinase
Prazo: 60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 6 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 6 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 8 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 8 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1b mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1b mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 4 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 4 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 10 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 10 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 17D mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 17D mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Atrogin-1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Atrogin-1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
Prazo: 30 min after exercise and protein intake, after 11-12 weeks of strength training
30 min after exercise and protein intake, after 11-12 weeks of strength training
Fasting cholesterol (only in elderly)
Prazo: Before training intervention
Before training intervention
Fasting cholesterol (only in elderly)
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting triglycerides (only in elderly)
Prazo: Before training intervention
Before training intervention
Fasting triglycerides (only in elderly)
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting LDL (only in elderly)
Prazo: Before training intervention
Before training intervention
Fasting LDL (only in elderly)
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting HDL (only in elderly)
Prazo: Before training intervention
Before training intervention
Fasting HDL (only in elderly)
Prazo: After 11-12 weeks of strength training
After 11-12 weeks of strength training

Colaboradores e Investigadores

É aqui que você encontrará pessoas e organizações envolvidas com este estudo.

Datas de registro do estudo

Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados ​​pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.

Datas Principais do Estudo

Início do estudo

1 de agosto de 2014

Conclusão Primária (Real)

1 de junho de 2015

Conclusão do estudo (Real)

1 de novembro de 2016

Datas de inscrição no estudo

Enviado pela primeira vez

19 de janeiro de 2017

Enviado pela primeira vez que atendeu aos critérios de CQ

24 de janeiro de 2017

Primeira postagem (Estimativa)

27 de janeiro de 2017

Atualizações de registro de estudo

Última Atualização Postada (Estimativa)

27 de janeiro de 2017

Última atualização enviada que atendeu aos critérios de controle de qualidade

24 de janeiro de 2017

Última verificação

1 de janeiro de 2017

Mais Informações

Termos relacionados a este estudo

Outros números de identificação do estudo

  • Tine 12wk

Plano para dados de participantes individuais (IPD)

Planeja compartilhar dados de participantes individuais (IPD)?

INDECISO

Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .

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