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Effects of Native Whey or Milk Supplementation on Adaptations to 12 Weeks of Strength Training in Young and Elderly

2017年1月24日 更新者:Truls Raastad、Norwegian School of Sport Sciences

Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly

The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.

研究概览

详细说明

Increasing or maintaining muscle mass is of great importance for populations ranging from athletes to patients and elderly. Resistance exercise and protein ingestion are two of the most potent stimulators of muscle protein synthesis. Both the physical characteristic of proteins (e.g. different digestion rates of whey and casein) and the amino acid composition, affects the potential of a certain protein to stimulate muscle protein synthesis. Given its superior ability to rapidly increase blood leucine concentrations to high levels, whey is often considered the most potent protein source to stimulate muscle protein synthesis. Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey has different characteristics than milk. Of special interest is the higher amounts of the highly anabolic amino acid leucine in native whey.

The higher levels of leucine can be of great interest for elderly individuals as some studies in elderly has shown an anabolic resistance to the effects of protein feeding and strength training. By increasing levels of leucine one might overcome this anabolic resistance in the elderly.

The aim of this double-blinded, randomized, partial cross-over study is to compare the changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training intervention with daily supplementation of either 2x20g of native whey or milk proteins in young and elderly individuals. In order to explain potential differences between supplements an acute study investigating acute responses in blood amino acid concentrations and intracellular signalling is planned, in a subgroup of participants, before and after the training intervention.

The investigators hypothesize that native whey will induce greater muscle hypertrophy and strength gains than milk.

研究类型

介入性

注册 (实际的)

66

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

      • Oslo、挪威、0863
        • Norwegian School of Sport Sciences

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

20年 及以上 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

描述

Inclusion Criteria:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral
  • Between 20 and 45, or above 70 years of age

Exclusion Criteria:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 主要用途:基础科学
  • 分配:随机化
  • 介入模型:并行分配
  • 屏蔽:四人间

武器和干预

参与者组/臂
干预/治疗
安慰剂比较:Milk supplementation
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g milk protein.
实验性的:Native whey
11 (elderly) or 12 (young) weeks of strength training and daily supplementation of 2x20g native whey protein.

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Lean mass
大体时间:Before the training intervention
Measured by whole body dual x-ray absorptiometry (DXA)
Before the training intervention
Lean mass
大体时间:After 11-12 weeks of strength training
Measured by whole body dual x-ray absorptiometry (DXA)
After 11-12 weeks of strength training

次要结果测量

结果测量
措施说明
大体时间
Thigh muscle cross sectional area
大体时间:Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Thigh muscle cross sectional area
大体时间:After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Pectoralis muscle cross sectional area
大体时间:Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Pectoralis muscle cross sectional area
大体时间:After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Arm cross sectional area
大体时间:Before the training intervention
Measured by magnetic resonance imaging (MRI)
Before the training intervention
Arm cross sectional area
大体时间:After 11-12 weeks of strength training
Measured by magnetic resonance imaging (MRI)
After 11-12 weeks of strength training
Thickness of the lateral vasti
大体时间:Before the training intervention
Measured by ultrasound
Before the training intervention
Thickness of the lateral vasti
大体时间:After 11-12 weeks of strength training
Measured by ultrasound
After 11-12 weeks of strength training
1 repetition maximum in leg press
大体时间:Before the training intervention
Before the training intervention
1 repetition maximum in leg press
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training
1 repetition maximum in bench press
大体时间:Before the training intervention
Before the training intervention
1 repetition maximum in bench press
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Ratio of phosphorylated to total ribosomal protein S6 kinase beta-1(P70S6K) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic elongation factor 2 (eEF-2) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, before the training intervention
Phosphorylation of phosphorylated to total eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1) change from baseline
大体时间:30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Biopsies from m. Vastus Lateralis was analyzed by western blot
30 min before and 2 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Plasma amino acid concentration
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Plasma amino acid concentration
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Muscle force generating capacity change from baseline
大体时间:15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, before the training intervention
Muscle force generating capacity change from baseline
大体时间:15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Measured as unilateral isometric knee extension force (Nm) with 90° in the hip and knee joints.
15 min before, 10 min, 2.5 hours and 24 hours after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum glucose
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum glucose
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum insulin
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum insulin
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum urea
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum urea
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Serum creatine kinase
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, before the training intervention
Serum creatine kinase
大体时间:60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
60 min before and 45, 60, 75 and 120 min after exercise and protein supplement intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa messenger ribonucleic acid (mRNA)
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Tumor necrosis factor alfa mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Tumor necrosis factor alfa mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 6 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 6 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 6 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 8 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 8 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 8 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1b mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1b mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1b mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 1 Receptor Antagonist mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 1 Receptor Antagonist mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 4 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 4 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 4 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 10 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 10 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 10 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Cholesterol 25-Hydroxylase mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Cholesterol 25-Hydroxylase mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 8 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 8 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Interleukin 17D mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Interleukin 17D mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Interleukin 17D mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 3 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 3 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-X-C Motif Chemokine Ligand 16 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-X-C Motif Chemokine Ligand 16 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
C-C Motif Chemokine Ligand 5 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
C-C Motif Chemokine Ligand 5 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 4 Group A Member 3 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Uncoupling Protein 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Uncoupling Protein 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Matrix Metallopeptidase 9 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Matrix Metallopeptidase 9 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
ATP Binding Cassette Subfamily A Member 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
ATP Binding Cassette Subfamily A Member 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Leukocyte Differentiation Antigen CD36 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Leukocyte Differentiation Antigen CD36 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Toll Like Receptor 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Toll Like Receptor 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Nuclear Receptor Subfamily 1 Group H Member 3 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 3 Member 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 3 Member 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 7 Member 5 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 7 Member 5 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 36 Member 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 36 Member 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Solute Carrier Family 38 Member 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Solute Carrier Family 38 Member 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Muscle-Specific RING Finger Protein 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Muscle-Specific RING Finger Protein 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Atrogin-1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Atrogin-1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Atrogin-1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box Protein O1A mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box Protein O1A mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Forkhead Box O3 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Forkhead Box O3 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 7 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 7 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 2 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 2 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myosin Heavy Chain 1mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myosin Heavy Chain 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Insulin Like Growth Factor 1 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Mast Cell Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Hepatocyte Growth Factor mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Myostatin mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Myostatin mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Striated Muscle Activator Of Rho-Dependent Signaling mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
JunB Proto-Oncogene, AP-1 Transcription Factor Subunit mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Actin, Alpha 1, Skeletal Muscle mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Colony Stimulating Factor 3 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Prostaglandin-Endoperoxide Synthase 2 mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
TATA-Box Binding Protein mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Filamin B mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Filamin B mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, after 11-12 weeks of strength training
2 hours after exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, before training intervention
30 min before exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
大体时间:2 hours after exercise and protein intake, before training intervention
2 hours after exercise and protein intake, before training intervention
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min before exercise and protein intake, after 11-12 weeks of strength training
30 min before exercise and protein intake, after 11-12 weeks of strength training
Beta-2-Microglobulin mRNA Myosin Heavy Chain 1 mRNA
大体时间:30 min after exercise and protein intake, after 11-12 weeks of strength training
30 min after exercise and protein intake, after 11-12 weeks of strength training
Fasting cholesterol (only in elderly)
大体时间:Before training intervention
Before training intervention
Fasting cholesterol (only in elderly)
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting triglycerides (only in elderly)
大体时间:Before training intervention
Before training intervention
Fasting triglycerides (only in elderly)
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting LDL (only in elderly)
大体时间:Before training intervention
Before training intervention
Fasting LDL (only in elderly)
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training
Fasting HDL (only in elderly)
大体时间:Before training intervention
Before training intervention
Fasting HDL (only in elderly)
大体时间:After 11-12 weeks of strength training
After 11-12 weeks of strength training

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2014年8月1日

初级完成 (实际的)

2015年6月1日

研究完成 (实际的)

2016年11月1日

研究注册日期

首次提交

2017年1月19日

首先提交符合 QC 标准的

2017年1月24日

首次发布 (估计)

2017年1月27日

研究记录更新

最后更新发布 (估计)

2017年1月27日

上次提交的符合 QC 标准的更新

2017年1月24日

最后验证

2017年1月1日

更多信息

与本研究相关的术语

其他研究编号

  • Tine 12wk

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)?

未定

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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