小児における食物手がかり反応に対する遺伝的素因
2024年11月18日 更新者：Diane Gilbert-Diamond、Trustees of Dartmouth College
遺伝的要因、食事の手がかり、自己規制と子供の過剰摂取および肥満の関係
この研究では、遺伝的要因、食物合図に関連する神経反応性、自己調節能力、空腹時以外の食事（EAH）、および小児の肥満増加の間の関連性を評価しています。
調査の概要
詳細な説明
研究者らは、遺伝的要因、食べ物の合図に関連する神経反応性、食べ物の合図に反応した空腹時の食事（EAH）、および小児の肥満増加の間の関連性を評価する予定である。 彼らはまた、自主規制能力がこれらの関連性を修正するかどうかも判断します。 具体的に調査された遺伝的要因には、FTO、MC4R、ドーパミン作動性経路に関与する遺伝子の多型、およびゲノム全体の肥満関連遺伝子座から構築された複合遺伝的リスクスコアが含まれます。
[2020/3/14]: 新型コロナウイルス感染症のパンデミックにより研究者の募集を一時停止しました
研究の種類
介入
入学 (実際)
189
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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New Hampshire
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Lebanon、New Hampshire、アメリカ、03756
- Dartmouth-Hitchcock
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
8年～12年 (子)
健康ボランティアの受け入れ
はい
説明
包含基準:
- 流暢な英語
- すべての研究訪問に参加する意欲があること
除外基準:
- 関連する食物アレルギーまたは食事制限
- ボディ内またはボディ上の金属
- 閉所恐怖症
- 精神障害および神経障害
- 研究の親戚
- 食欲や注意力を変える薬や病気
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：防止
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
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アクティブコンパレータ：食品広告と fMRI
FMRIスキャン中に食品広告にさらされる
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年齢に応じたテレビ番組に組み込まれた食品広告に触れる
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偽コンパレータ：食品以外の広告と fMRI
FMRIスキャン中に食品以外の広告にさらされる
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年齢に応じたテレビ番組に埋め込まれた食品以外の広告を目にする
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アクティブコンパレータ：食品広告とテレビ番組
年齢に応じたテレビ番組に埋め込まれた食品広告に触れる
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年齢に応じたテレビ番組に組み込まれた食品広告に触れる
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偽コンパレータ：食品以外の広告とテレビ番組
年齢に応じたテレビ番組に埋め込まれた食品以外の広告を目にする
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年齢に応じたテレビ番組に埋め込まれた食品以外の広告を目にする
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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食べ物の合図に関連する神経活動
時間枠：ベースライン
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FMRIスキャン中の血中酸素濃度依存性反応の違いによって測定される、食物と非食物の合図に反応した脳の報酬領域の活性化。
研究者らは、FTO、MC4R の多型間の関連性、および遺伝的リスクスコアと異なる神経活動との関連性を調査する予定です。
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ベースライン
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食べ物の合図に関連した空腹時の食事 (EAH)
時間枠：ベースライン、2週間、4週間
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行動セッションにおける食物と非食物刺激への曝露に応じて消費されるkcalの差。
研究者らは、食物の合図と非食物の合図に反応する異なる神経活動がEAHにどのように関係するかを調査する予定である。
研究者らはまた、自己調節能力が差次的神経活動とEAHとの関連性を減少させるかどうかも評価する予定である。
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ベースライン、2週間、4週間
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BMIの変化
時間枠：ベースライン、1年間の追跡調査
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ベースラインとフォローアップで評価された Center for DiseaSe Control 2000 Growth Reference Curves に基づく BMI z スコア間の差。
研究者らは、遺伝的要因（FTO、MC4Rの多型、および遺伝的肥満リスクスコア）、食物合図に関連する神経活動、およびBMIの変化とEAHの間の関連性を評価する予定である。
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ベースライン、1年間の追跡調査
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
協力者
捜査官
- 主任研究者：Diane Gilbert-Diamond, ScD、Dartmouth-Hitchcock Medical Center
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
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Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.
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研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2019年1月10日
一次修了 (実際)
2024年3月27日
研究の完了 (実際)
2024年3月27日
試験登録日
最初に提出
2018年12月4日
QC基準を満たした最初の提出物
2018年12月4日
最初の投稿 (実際)
2018年12月6日
学習記録の更新
投稿された最後の更新 (実際)
2024年11月21日
QC基準を満たした最後の更新が送信されました
2024年11月18日
最終確認日
2024年11月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。