Predisposição genética para reatividade alimentar em crianças
18 de novembro de 2024 atualizado por: Diane Gilbert-Diamond, Trustees of Dartmouth College
A relação de fatores genéticos, sinais alimentares e autorregulação com excesso de consumo e adiposidade em crianças
Este estudo avalia as associações entre fatores genéticos, reatividade neural relacionada aos estímulos alimentares, capacidade autorregulatória, alimentação na ausência de fome (EAH) e ganho de adiposidade em crianças.
Visão geral do estudo
Status
Concluído
Condições
Intervenção / Tratamento
Descrição detalhada
Os investigadores avaliarão as associações entre fatores genéticos, reatividade neural relacionada aos sinais alimentares, alimentação na ausência de fome (EAH) em resposta aos sinais alimentares e ganho de adiposidade em crianças. Também determinarão se a capacidade de auto-regulação modifica estas associações. Os fatores genéticos explorados incluem especificamente FTO, MC4R, polimorfismos em genes envolvidos em vias dopaminérgicas e um escore de risco genético composto construído a partir de loci relacionados à obesidade em todo o genoma.
[14/03/2020]: Recrutamento para estudo temporariamente suspenso devido à pandemia de COVID-19
Tipo de estudo
Intervencional
Inscrição (Real)
189
Estágio
- Não aplicável
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Locais de estudo
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New Hampshire
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Lebanon, New Hampshire, Estados Unidos, 03756
- Dartmouth-Hitchcock
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Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
8 anos a 12 anos (Filho)
Aceita Voluntários Saudáveis
Sim
Descrição
Critério de inclusão:
- Fluência em inglês
- Disponibilidade para participar em todas as visitas de estudo
Critério de exclusão:
- Alergias alimentares relevantes ou restrições alimentares
- Metal dentro ou sobre o corpo
- Claustrofobia
- Distúrbios psiquiátricos e neurológicos
- Parente no estudo
- Medicamentos ou distúrbios que alteram o apetite ou a atenção
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Prevenção
- Alocação: Randomizado
- Modelo Intervencional: Atribuição cruzada
- Mascaramento: Solteiro
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
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Comparador Ativo: Anúncios de alimentos e fMRI
Exposição a anúncios de alimentos durante uma ressonância magnética funcional
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Exposição a anúncios de alimentos incorporados em um programa de TV adequado à idade
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Comparador Falso: Anúncios não alimentares e fMRI
Exposição a anúncios não alimentares durante uma ressonância magnética funcional
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Exposição a anúncios não alimentares incorporados num programa de televisão adequado à idade
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Comparador Ativo: Anúncios de alimentos e programas de TV
Exposição a anúncios de alimentos incorporados em um programa de TV adequado à idade
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Exposição a anúncios de alimentos incorporados em um programa de TV adequado à idade
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Comparador Falso: Anúncios não alimentares e programas de TV
Exposição a anúncios não alimentares incorporados num programa de televisão adequado à idade
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Exposição a anúncios não alimentares incorporados num programa de televisão adequado à idade
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Atividade neural relacionada ao estímulo alimentar
Prazo: Linha de base
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Ativação em regiões de recompensa do cérebro em resposta a sinais alimentares versus sinais não alimentares, conforme medido pelas diferenças na resposta dependente do nível de oxigênio no sangue durante exames de fMRI.
Os investigadores examinarão associações entre polimorfismos em FTO, MC4R, bem como uma pontuação de risco genético com a atividade neural diferencial.
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Linha de base
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Alimentação relacionada a sugestões alimentares na ausência de fome (EAH)
Prazo: Linha de base, 2 semanas, 4 semanas
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Diferença em kcal consumidas em resposta à exposição a estímulos alimentares versus não alimentares nas sessões comportamentais.
Os investigadores examinarão como a atividade neural diferencial em resposta a sinais alimentares versus não alimentares se relacionará com EAH.
Os investigadores também avaliarão se a capacidade autorregulatória diminui esta associação entre atividade neural diferencial e EAH.
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Linha de base, 2 semanas, 4 semanas
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Mudança no IMC
Prazo: Linha de base, acompanhamento de 1 ano
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Diferença entre o escore z do IMC de acordo com as curvas de referência de crescimento do Center for DiseaSe Control 2000 avaliadas no início do estudo e no acompanhamento.
Os investigadores avaliarão as associações entre fatores genéticos (polimorfismos em FTO, MC4R; e um escore de risco de obesidade genética), atividade neural relacionada a estímulos alimentares e EAH com mudança no IMC.
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Linha de base, acompanhamento de 1 ano
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Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Diane Gilbert-Diamond, ScD, Dartmouth-Hitchcock Medical Center
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
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LifeLines Cohort Study; Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gadin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JRB, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, van 't Hooft FM, Vinkhuyzen AAE, Westra HJ, Zheng W, Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrieres J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Illig T, Jacobs KB, Jarvelin MR, Jockel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJP, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Marchand LL, Lehtimaki T, Lyssenko V, Mannisto S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PAF, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PEH, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tonjes A, Tregouet DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Volker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, Marz W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njolstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Perusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJF, Speliotes EK. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.
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Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
10 de janeiro de 2019
Conclusão Primária (Real)
27 de março de 2024
Conclusão do estudo (Real)
27 de março de 2024
Datas de inscrição no estudo
Enviado pela primeira vez
4 de dezembro de 2018
Enviado pela primeira vez que atendeu aos critérios de CQ
4 de dezembro de 2018
Primeira postagem (Real)
6 de dezembro de 2018
Atualizações de registro de estudo
Última Atualização Postada (Real)
21 de novembro de 2024
Última atualização enviada que atendeu aos critérios de controle de qualidade
18 de novembro de 2024
Última verificação
1 de novembro de 2024
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- D19064
- 1R01HD092604 (Concessão/Contrato do NIH dos EUA)
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
NÃO
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Não
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .