Генетическая предрасположенность к реакции на пищевые сигналы у детей
18 ноября 2024 г. обновлено: Diane Gilbert-Diamond, Trustees of Dartmouth College
Связь генетических факторов, пищевых сигналов и саморегуляции с избыточным потреблением и ожирением у детей
В этом исследовании оцениваются связи между генетическими факторами, нервной реактивностью, связанной с пищевыми сигналами, способностью к саморегуляции, питанием при отсутствии голода (EAH) и ожирением у детей.
Обзор исследования
Статус
Завершенный
Условия
Вмешательство/лечение
Подробное описание
Исследователи оценят связь между генетическими факторами, нейронной реактивностью, связанной с пищевыми сигналами, приемом пищи при отсутствии голода (EAH) в ответ на пищевые сигналы и увеличением ожирения у детей. Они также определят, изменяет ли способность саморегулирования эти ассоциации. В частности, изученные генетические факторы включают FTO, MC4R, полиморфизмы в генах, участвующих в дофаминергических путях, а также комплексный показатель генетического риска, построенный на основе полногеномных локусов, связанных с ожирением.
[14.03.2020]: Набор участников исследования временно приостановлен из-за пандемии COVID-19.
Тип исследования
Интервенционный
Регистрация (Действительный)
189
Фаза
- Непригодный
Контакты и местонахождение
В этом разделе приведены контактные данные лиц, проводящих исследование, и информация о том, где проводится это исследование.
Места учебы
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New Hampshire
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Lebanon, New Hampshire, Соединенные Штаты, 03756
- Dartmouth-Hitchcock
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Критерии участия
Исследователи ищут людей, которые соответствуют определенному описанию, называемому критериям приемлемости. Некоторыми примерами этих критериев являются общее состояние здоровья человека или предшествующее лечение.
Критерии приемлемости
Возраст, подходящий для обучения
От 8 лет до 12 лет (Ребенок)
Принимает здоровых добровольцев
Да
Описание
Критерии включения:
- свободное владение английским языком
- Готовность участвовать во всех учебных визитах
Критерий исключения:
- Соответствующая пищевая аллергия или диетические ограничения.
- Металл внутри или на корпусе
- Клаустрофобия
- Психиатрические и неврологические расстройства
- Родственник в исследовании
- Лекарства или расстройства, изменяющие аппетит или внимание
Учебный план
В этом разделе представлена подробная информация о плане исследования, в том числе о том, как планируется исследование и что оно измеряет.
Как устроено исследование?
Детали дизайна
- Основная цель: Профилактика
- Распределение: Рандомизированный
- Интервенционная модель: Назначение кроссовера
- Маскировка: Одинокий
Оружие и интервенции
Группа участников / Армия |
Вмешательство/лечение |
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Активный компаратор: Реклама продуктов питания и фМРТ
Воздействие рекламы продуктов питания во время МРТ-сканирования
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Просмотр рекламы продуктов питания, встроенной в телепрограмму, соответствующую возрасту
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Фальшивый компаратор: Реклама непродовольственных товаров и фМРТ
Воздействие рекламы непродовольственных товаров во время МРТ-сканирования
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Просмотр рекламы непродовольственных товаров, встроенной в телепрограмму, соответствующую возрасту
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Активный компаратор: Реклама еды и телешоу
Просмотр рекламы продуктов питания, встроенной в телепрограмму, соответствующую возрасту
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Просмотр рекламы продуктов питания, встроенной в телепрограмму, соответствующую возрасту
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Фальшивый компаратор: Непродовольственная реклама и телешоу
Просмотр рекламы непродовольственных товаров, встроенной в телепрограмму, соответствующую возрасту
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Просмотр рекламы непродовольственных товаров, встроенной в телепрограмму, соответствующую возрасту
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Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
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Нервная активность, связанная с пищевыми сигналами
Временное ограничение: Базовый уровень
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Активация областей вознаграждения мозга в ответ на пищевые и непищевые сигналы, что измеряется по различиям в реакции, зависящей от уровня кислорода в крови, во время сканирования фМРТ.
Исследователи изучат ассоциации между полиморфизмами FTO, MC4R, а также оценку генетического риска с дифференциальной нейронной активностью.
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Базовый уровень
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Еда, связанная с пищевыми сигналами, при отсутствии голода (EAH)
Временное ограничение: Исходный уровень, 2 недели, 4 недели
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Разница в потреблении ккал в ответ на воздействие пищевых и непищевых сигналов на поведенческих сессиях.
Исследователи изучат, как дифференциальная нейронная активность в ответ на пищевые и непищевые сигналы будет связана с EAH.
Исследователи также оценят, уменьшает ли способность к саморегуляции эту связь между дифференциальной нейронной активностью и ЭАГ.
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Исходный уровень, 2 недели, 4 недели
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Изменение ИМТ
Временное ограничение: Исходный уровень, наблюдение через 1 год
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Разница между z-показателем ИМТ в соответствии с эталонными кривыми роста Центра контроля заболеваний 2000 года, оцененными на исходном уровне и в последующем.
Исследователи оценят связь между генетическими факторами (полиморфизмами в FTO, MC4R и показателем генетического риска ожирения), нейронной активностью, связанной с пищевыми сигналами, и ЭАГ с изменением ИМТ.
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Исходный уровень, наблюдение через 1 год
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Соавторы и исследователи
Здесь вы найдете людей и организации, участвующие в этом исследовании.
Спонсор
Соавторы
Следователи
- Главный следователь: Diane Gilbert-Diamond, ScD, Dartmouth-Hitchcock Medical Center
Публикации и полезные ссылки
Лицо, ответственное за внесение сведений об исследовании, добровольно предоставляет эти публикации. Это может быть что угодно, связанное с исследованием.
Общие публикации
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Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.
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Даты записи исследования
Эти даты отслеживают ход отправки отчетов об исследованиях и сводных результатов на сайт ClinicalTrials.gov. Записи исследований и сообщаемые результаты проверяются Национальной медицинской библиотекой (NLM), чтобы убедиться, что они соответствуют определенным стандартам контроля качества, прежде чем публиковать их на общедоступном веб-сайте.
Изучение основных дат
Начало исследования (Действительный)
10 января 2019 г.
Первичное завершение (Действительный)
27 марта 2024 г.
Завершение исследования (Действительный)
27 марта 2024 г.
Даты регистрации исследования
Первый отправленный
4 декабря 2018 г.
Впервые представлено, что соответствует критериям контроля качества
4 декабря 2018 г.
Первый опубликованный (Действительный)
6 декабря 2018 г.
Обновления учебных записей
Последнее опубликованное обновление (Действительный)
21 ноября 2024 г.
Последнее отправленное обновление, отвечающее критериям контроля качества
18 ноября 2024 г.
Последняя проверка
1 ноября 2024 г.
Дополнительная информация
Термины, связанные с этим исследованием
Ключевые слова
Дополнительные соответствующие термины MeSH
Другие идентификационные номера исследования
- D19064
- 1R01HD092604 (Грант/контракт NIH США)
Планирование данных отдельных участников (IPD)
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НЕТ
Информация о лекарствах и устройствах, исследовательские документы
Изучает лекарственный продукт, регулируемый FDA США.
Нет
Изучает продукт устройства, регулируемый Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов США.
Нет
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .