Lasten geneettinen taipumus ruokareaktiivisuuteen
maanantai 18. marraskuuta 2024 päivittänyt: Diane Gilbert-Diamond, Trustees of Dartmouth College
Geneettisten tekijöiden, ruokamerkkien ja itsesääntelyn suhde lasten liialliseen kulutukseen ja lihavuuteen
Tässä tutkimuksessa arvioidaan geneettisten tekijöiden, ravintoon liittyvän hermoston reaktiivisuuden, itsesäätelykyvyn, syömisen ilman nälkää (EAH) ja lasten lihavuuden lisääntymisen välisiä yhteyksiä.
Tutkimuksen yleiskatsaus
Tila
Valmis
Ehdot
Interventio / Hoito
Yksityiskohtainen kuvaus
Tutkijat arvioivat geneettisten tekijöiden, ruokiin liittyvän hermoston reaktiivisuuden, syömisen ilman nälkää (EAH) vastauksena ruokavihjeisiin ja lasten lihavuuden lisääntymisen välisiä yhteyksiä. He myös määrittävät, muuttaako itsesääntelykyky näitä yhdistyksiä. Erityisesti tutkittuihin geneettisiin tekijöihin kuuluvat FTO, MC4R, dopaminergisiin reitteihin osallistuvien geenien polymorfismit ja yhdistelmä geneettinen riskipisteet, jotka on rakennettu genominlaajuisista liikalihavuuteen liittyvistä lokuksista.
[3/14/2020]: Opintoihin rekrytointi keskeytetty väliaikaisesti COVID-19-pandemian vuoksi
Opintotyyppi
Interventio
Ilmoittautuminen (Todellinen)
189
Vaihe
- Ei sovellettavissa
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskelupaikat
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New Hampshire
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Lebanon, New Hampshire, Yhdysvallat, 03756
- Dartmouth-Hitchcock
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Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
8 vuotta - 12 vuotta (Lapsi)
Hyväksyy terveitä vapaaehtoisia
Joo
Kuvaus
Sisällyttämiskriteerit:
- Englannin sujuvuus
- Halukkuus osallistua kaikkiin opintovierailuihin
Poissulkemiskriteerit:
- Asiaankuuluvat ruoka-aineallergiat tai ruokavaliorajoitukset
- Metallia rungossa tai sen päällä
- Klaustrofobia
- Psykiatriset ja neurologiset häiriöt
- Sukulainen tutkimuksessa
- Ruokahalua tai huomiota muuttavat lääkkeet tai häiriöt
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Ennaltaehkäisy
- Jako: Satunnaistettu
- Inventiomalli: Crossover-tehtävä
- Naamiointi: Yksittäinen
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
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Active Comparator: Ruokamainokset ja fMRI
Altistuminen ruokamainoksille fMRI-skannauksen aikana
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Altistuminen ruokamainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Huijausvertailija: Muut kuin ruokamainokset ja fMRI
Altistuminen non food -mainoksille fMRI-skannauksen aikana
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Altistuminen ei-elintarvikemainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Active Comparator: Ruokamainokset ja TV-ohjelma
Altistuminen ruokamainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Altistuminen ruokamainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Huijausvertailija: Muut kuin ruokamainokset ja TV-ohjelma
Altistuminen ei-elintarvikemainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Altistuminen ei-elintarvikemainoksille, jotka on upotettu ikään sopivaan TV-ohjelmaan
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Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
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Ruokavihjeisiin liittyvä hermotoiminta
Aikaikkuna: Perustaso
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Aktivaatio aivojen palkitsemisalueilla vasteena ruokaan verrattuna ei-ruokaan, mitattuna eroilla veren happitasosta riippuvaisessa vasteessa fMRI-skannausten aikana.
Tutkijat tutkivat FTO:n ja MC4R:n polymorfismien välisiä assosiaatioita sekä geneettisen riskin pisteytystä differentiaalisen hermotoiminnan kanssa.
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Perustaso
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Ruokavalioon liittyvä syöminen nälän poissa ollessa (EAH)
Aikaikkuna: Perustaso, 2 viikkoa, 4 viikkoa
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Ero kcal-arvoissa, jotka kulutettiin vasteena ruoaksi verrattuna altistumiseen muuhun kuin ruokaan käyttäytymisjaksojen aikana.
Tutkijat tutkivat, kuinka hermoston erilainen aktiivisuus vasteena ruokaan verrattuna muihin vihjeisiin liittyy EAH:hen.
Tutkijat arvioivat myös, vähentääkö itsesäätelykyky tätä yhteyttä differentiaalisen hermotoiminnan ja EAH:n välillä.
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Perustaso, 2 viikkoa, 4 viikkoa
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Muutos BMI:ssä
Aikaikkuna: Lähtötilanne, 1 vuoden seuranta
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Ero BMI:n z-pisteiden välillä Center for DiseaSe Control 2000 Growth Reference -käyrien mukaan arvioituna lähtötilanteessa ja seurannassa.
Tutkijat arvioivat geneettisten tekijöiden (polymorfismit FTO:ssa, MC4R:ssä ja geneettisen liikalihavuuden riskipisteen), ruokaan liittyvän hermotoiminnan ja EAH:n välisiä yhteyksiä BMI:n muutokseen.
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Lähtötilanne, 1 vuoden seuranta
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Yhteistyökumppanit ja tutkijat
Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.
Sponsori
Yhteistyökumppanit
Tutkijat
- Päätutkija: Diane Gilbert-Diamond, ScD, Dartmouth-Hitchcock Medical Center
Julkaisuja ja hyödyllisiä linkkejä
Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.
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Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.
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Muita asiaankuuluvia MeSH-ehtoja
Muut tutkimustunnusnumerot
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