어린이의 음식 신호 반응성에 대한 유전적 소인
2024년 11월 18일 업데이트: Diane Gilbert-Diamond, Trustees of Dartmouth College
소아의 과식 및 비만과 유전적 요인, 음식단서, 자기조절과의 관계 원문보기 KCI 원문보기 인용
이 연구는 어린이의 유전적 요인, 음식 신호 관련 신경 반응성, 자기 조절 능력, 배고픔 없는 식사(EAH), 지방 증가 사이의 연관성을 평가합니다.
연구 개요
상세 설명
조사관은 유전적 요인, 음식 신호 관련 신경 반응성, 음식 신호에 대한 반응으로 배고픔이 없을 때 식사(EAH), 어린이의 지방 증가 사이의 연관성을 평가할 것입니다. 그들은 또한 자율 규제 능력이 이러한 연관성을 수정하는지 여부를 결정할 것입니다. 구체적으로 탐색된 유전적 요인에는 FTO, MC4R, 도파민성 경로와 관련된 유전자의 다형성, 게놈 차원의 비만 관련 유전자좌에서 구축된 복합 유전적 위험 점수가 포함됩니다.
[2020년 3월 14일]: COVID-19 전염병으로 인해 연구 모집이 일시적으로 중단되었습니다.
연구 유형
중재적
등록 (실제)
189
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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New Hampshire
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Lebanon, New Hampshire, 미국, 03756
- Dartmouth-Hitchcock
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
8년 (어린이)
건강한 자원 봉사자를 받아들입니다
예
설명
포함 기준:
- 영어 유창성
- 모든 연구 방문에 참여할 의향
제외 기준:
- 관련 음식 알레르기 또는 식이 제한
- 신체 안팎의 금속
- 밀실 공포증
- 정신 및 신경 장애
- 연구의 친척
- 식욕 또는 주의력을 변화시키는 약물 또는 장애
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 방지
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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활성 비교기: 음식 광고 및 fMRI
FMRI 스캔 중 음식 광고에 노출
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연령에 적합한 TV 프로그램에 삽입된 식품 광고에 노출
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가짜 비교기: 비식품 광고 및 fMRI
FMRI 스캔 중 비식품 광고에 노출
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연령에 적합한 TV 프로그램에 삽입된 비식품 광고에 노출
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활성 비교기: 음식 광고 및 TV 쇼
연령에 적합한 TV 프로그램에 삽입된 음식 광고에 노출
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연령에 적합한 TV 프로그램에 삽입된 식품 광고에 노출
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가짜 비교기: 비식품 광고 및 TV 쇼
연령에 적합한 TV 프로그램에 삽입된 비식품 광고에 노출
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연령에 적합한 TV 프로그램에 삽입된 비식품 광고에 노출
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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음식 신호 관련 신경 활동
기간: 기준선
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FMRI 스캔 중 혈중 산소 수준 의존적 반응의 차이로 측정한 음식 대 비음식 단서에 대한 뇌 보상 영역의 활성화.
조사관은 FTO, MC4R의 다형성과 차등 신경 활동의 유전적 위험 점수 사이의 연관성을 조사할 것입니다.
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기준선
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배고픔이 없을 때 음식 단서와 관련된 식사(EAH)
기간: 기준선, 2주, 4주
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행동 세션에서 음식과 비음식 신호 노출에 대한 반응으로 소비된 kcal의 차이.
수사관은 음식 대 비 음식 단서에 대한 반응의 차등 신경 활동이 EAH와 어떻게 관련되는지 조사할 것입니다.
조사관은 또한 자가 조절 능력이 차등 신경 활동과 EAH 사이의 연관성을 감소시키는지 여부를 평가할 것입니다.
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기준선, 2주, 4주
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BMI의 변화
기간: 기준선, 1년 후속 조치
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Center for Disease Control 2000 Growth Reference Curves에 따른 BMI z-점수의 차이는 기준선과 후속 조치에서 평가되었습니다.
조사관은 유전적 요인(FTO, MC4R의 다형성, 유전적 비만 위험 점수), 음식 신호 관련 신경 활동 및 BMI 변화에 따른 EAH 사이의 연관성을 평가할 것입니다.
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기준선, 1년 후속 조치
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
협력자
수사관
- 수석 연구원: Diane Gilbert-Diamond, ScD, Dartmouth-Hitchcock Medical Center
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
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