Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area (POG-C)
Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and executive functions. Many studies describe the supplementary motor area syndrome resulting from lesions in this area. News managements for LGGs consisting in intraoperative mapping in awake patients reduce significantly neurological disorders and increase also the overall survival . However, the literature does not provide data concerning motor and cognitive functions in a long term and their consequences in the quality of life of patients.
Objective : The aim of our research project is to identify whether there are some motor or neurocognitive deficit in the short and the long term in a population of patients who have medical story of LGG resection in the supplementary motor area.
調査の概要
詳細な説明
研究の種類
入学 (実際)
連絡先と場所
研究場所
-
-
-
Tours、フランス、37044
- University Hospital
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- 18 years of age or older
- Have a history of low-grade diffuse glioma resection
- Visiting the University Hospital for a follow-up neurosurgical consultation
- Underwent awake surgery
Exclusion Criteria:
- Presence of cognitive disorders that do not allow the proposed test battery to be performed
- Under guardianship or curatorship
- Opposition to the participation to the research
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
|
Case
patients with a history of surgical removal of diffuse low grade glioma located in the supplementary motor area
|
motor and neuropsychological test battery
|
|
Control
patients with a history of surgical removal of diffuse low-grade glioma located in another brain area
|
motor and neuropsychological test battery
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
motor tests in the case group - 400 point assessment
時間枠：inclusion visit
|
analysis of the scores obtained at the tests 4 tests :
|
inclusion visit
|
|
neuropsychological tests in the case group
時間枠：inclusion visit
|
analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values |
inclusion visit
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
motor tests in the control group - 400 point assessment
時間枠：inclusion visit
|
analysis of the scores obtained at the tests 4 tests :
|
inclusion visit
|
|
neuropsychological tests in the control group
時間枠：inclusion visit
|
analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values |
inclusion visit
|
|
Brain MRI
時間枠：inclusion visit
|
Analysis of the location of diffuse low-grade gliomas
|
inclusion visit
|
|
Brain MRI
時間枠：inclusion visit
|
Analysis of the lesion volume of diffuse low-grade gliomas
|
inclusion visit
|
|
quality of life self-questionnaire carried out at home : sickness Impact Profile
時間枠：inclusion visit
|
analysis of the results obtained 136 questions with responses True or False Minimum value = 0 Maximum value = 136 136/136 means that the quality of life is very negatively affected
|
inclusion visit
|
|
fatigue self-questionnaire carried out at home : fatigue Impact Scale (FIS)
時間枠：inclusion visit
|
analysis of the results obtained 40 questions with responses
|
inclusion visit
|
協力者と研究者
捜査官
- 主任研究者：Ilyess ZEMMOURA、University Hospital, Tours
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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