Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area (POG-C)
Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and executive functions. Many studies describe the supplementary motor area syndrome resulting from lesions in this area. News managements for LGGs consisting in intraoperative mapping in awake patients reduce significantly neurological disorders and increase also the overall survival . However, the literature does not provide data concerning motor and cognitive functions in a long term and their consequences in the quality of life of patients.
Objective : The aim of our research project is to identify whether there are some motor or neurocognitive deficit in the short and the long term in a population of patients who have medical story of LGG resection in the supplementary motor area.
研究概览
详细说明
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
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Tours、法国、37044
- University Hospital
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- 18 years of age or older
- Have a history of low-grade diffuse glioma resection
- Visiting the University Hospital for a follow-up neurosurgical consultation
- Underwent awake surgery
Exclusion Criteria:
- Presence of cognitive disorders that do not allow the proposed test battery to be performed
- Under guardianship or curatorship
- Opposition to the participation to the research
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Case
patients with a history of surgical removal of diffuse low grade glioma located in the supplementary motor area
|
motor and neuropsychological test battery
|
|
Control
patients with a history of surgical removal of diffuse low-grade glioma located in another brain area
|
motor and neuropsychological test battery
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
motor tests in the case group - 400 point assessment
大体时间：inclusion visit
|
analysis of the scores obtained at the tests 4 tests :
|
inclusion visit
|
|
neuropsychological tests in the case group
大体时间：inclusion visit
|
analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values |
inclusion visit
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
motor tests in the control group - 400 point assessment
大体时间：inclusion visit
|
analysis of the scores obtained at the tests 4 tests :
|
inclusion visit
|
|
neuropsychological tests in the control group
大体时间：inclusion visit
|
analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values |
inclusion visit
|
|
Brain MRI
大体时间：inclusion visit
|
Analysis of the location of diffuse low-grade gliomas
|
inclusion visit
|
|
Brain MRI
大体时间：inclusion visit
|
Analysis of the lesion volume of diffuse low-grade gliomas
|
inclusion visit
|
|
quality of life self-questionnaire carried out at home : sickness Impact Profile
大体时间：inclusion visit
|
analysis of the results obtained 136 questions with responses True or False Minimum value = 0 Maximum value = 136 136/136 means that the quality of life is very negatively affected
|
inclusion visit
|
|
fatigue self-questionnaire carried out at home : fatigue Impact Scale (FIS)
大体时间：inclusion visit
|
analysis of the results obtained 40 questions with responses
|
inclusion visit
|
合作者和调查者
调查人员
- 首席研究员：Ilyess ZEMMOURA、University Hospital, Tours
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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