トラウマ後の健康に対するポジティブな記憶への治療的焦点の影響の調査
心的外傷後ストレス障害の新しい治療法の検討と改良: ポジティブ メモリー テクニック (PPMT) の処理
心的外傷後ストレス障害 (PTSD) は、健康に壊滅的な影響を及ぼします。 証拠に基づく PTSD 介入は、個人と社会の健康に対する PTSD の実質的な負担に対処します。しかし、これらの介入を受けている何人かの人は脱落し、すべての人が PTSD 症状の改善を経験するわけではありません。 さらに、これらの現在の PTSD 介入は、主にトラウマの記憶を対象としています。 特に、増加する証拠は、PTSDの症状がポジティブな記憶のコード化と検索の困難にも関連していることを示唆しています.
したがって、提案された研究では、ポジティブ メモリーのナレーションと詳細化に焦点を当てた新しい PTSD テクニック - ポジティブ メモリー テクニック (PPMT) の処理の効果とその根底にあるターゲットを調べます。 方法論的に、70 人の個人が、この研究のために PPMT 対支持カウンセリング (SC) に無作為に割り当てられます。
提案された研究の目的には、(1) PTSD 症状の重症度とストレス システムの調節不全 (すなわち、唾液アルファ アミラーゼ [sAA] とコルチゾールの覚醒) に対する PPMT の影響を調べることが含まれます。 (2) PPMT の効果の根底にあるメカニズムを調べる。 （3）PPMTの改良。 PPMT アームは、PTSD の重症度と sAA/コルチゾール比の大幅な減少を報告すると仮定されています。 さらに、PPMT 関連の改善された感情が、研究群 (PPMT 対 SC) と PTSD 重症度の変化との関連を仲介すると仮定されます。 最後に、PPMT の実現可能性、形式、および内容に関するフィードバックを調査参加者から得て、PPMT を改良します。
提案された研究は、PTSD介入においてポジティブな記憶を対象とすることの潜在的な重要性に関する予備的な証拠に貢献する可能性があります。
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Texas
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Denton、Texas、アメリカ、76203
- University of North Texas
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
説明
包含基準:
- 18～65歳
- -インフォームドコンセントを提供する意思がある/できる
- 過去 1 か月の DSM-5 心的外傷後ストレス障害 (PTSD) の診断
- 英語の実務知識
除外基準:
- 積極的な自殺の意図または試み
- 活動性精神病
- 現在メンタルヘルス治療を受けている（過去3か月）
- 精神科の薬の服用量の変化（過去3ヶ月）
- 現在妊娠中
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
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アクティブコンパレータ：ポジティブ メモリー テクニックの処理 (PPMT)
参加者は、PPMT 療法マニュアルに概説されている治療手順に従って、PTSD の 60 分間の正記憶処理法 (PPMT) セッションを 5 回受けます。
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PPMT は、ポジティブな記憶の特定と処理に焦点を当てた 5 つのセッションで構成されています。
セッション 1-5 では、参加者は 1 つの肯定的な記憶の詳細を語り、肯定的な記憶を処理して、肯定的な価値、影響、強み、思考を引き出します。
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アクティブコンパレータ：サポートカウンセリング（SC）
参加者は、60 分間の支持カウンセリング (SC) セッションを 5 回受けます。
SC には、毎日のモニタリング ダイアリーの説明と、現在の問題と懸念事項の調査が含まれます。
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SC は、毎週実施される 5 セッションのアクティブで非特異的な治療であり、毎日のモニタリング ダイアリーのディスカッションと、現在の問題や懸念事項の調査が含まれます。
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Baseline
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Baseline
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Week 1 post-baseline during therapy session
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Week 1 post-baseline during therapy session
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Week 2 post-baseline during therapy session
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Week 2 post-baseline during therapy session
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Week 3 post-baseline during therapy session
|
The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Week 3 post-baseline during therapy session
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Week 4 post-baseline during therapy session
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Week 4 post-baseline during therapy session
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：Week 5 post-baseline during therapy session
|
The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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Week 5 post-baseline during therapy session
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：1 week after the last therapy session, at week 6 post-baseline
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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1 week after the last therapy session, at week 6 post-baseline
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Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) Scores
時間枠：3-months posttreatment completion, at week 18 post-baseline
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The 20-item self-report PTSD Checklist for DSM-5 (PCL-5) assessed past-week posttraumatic stress disorder (PTSD) severity.
Response options ranged from 0 (not at all) to 4 (extremely), with the possible range being from 0 to 80. Higher scores indicate more PTSD symptom severity.
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3-months posttreatment completion, at week 18 post-baseline
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Awakening Salivary Alpha Amylase to Cortisol Ratio
時間枠：3 times each day for 2 consecutive days prior to first therapy session
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Via a passive drool procedure, participants provided 3 whole saliva samples each day for 2 consecutive days both prior to PPMT/SC: (1) immediately upon awakening, (2) 30 minutes post-awakening, and (3) 60 minutes post-awakening.
For each marker, for each day, area under the curve with respect to ground (AUCg) was calculated.
The two-day average AUCg of sAA was then divided by the two-day average AUCg of cortisol to create the ratio variable.
Higher sAA/cortisol ratio indicates greater stress system dysregulation and sympathetic nervous system dominance.
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3 times each day for 2 consecutive days prior to first therapy session
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Awakening Salivary Alpha Amylase to Cortisol Ratio
時間枠：3 times each day for 2 consecutive days after the last therapy session
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Via a passive drool procedure, participants provided 3 whole saliva samples each day for 2 consecutive days one week following PPMT/SC: (1) immediately upon awakening, (2) 30 minutes post-awakening, and (3) 60 minutes post-awakening.
For each marker, for each day, area under the curve with respect to ground (AUCg) was calculated.
The two-day average AUCg of sAA was then divided by the two-day average AUCg of cortisol to create the ratio variable.
Higher sAA/cortisol ratio indicates greater stress system dysregulation and sympathetic nervous system dominance.
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3 times each day for 2 consecutive days after the last therapy session
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Positive and Negative Affect Schedule
時間枠：Baseline
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Baseline
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Positive and Negative Affect Schedule
時間枠：Week 1 post-baseline during therapy session
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Week 1 post-baseline during therapy session
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Positive and Negative Affect Schedule
時間枠：Week 2 post-baseline during therapy session
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Week 2 post-baseline during therapy session
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Positive and Negative Affect Schedule
時間枠：Week 3 post-baseline during therapy session
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Week 3 post-baseline during therapy session
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Positive and Negative Affect Schedule
時間枠：Week 4 post-baseline during therapy session
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Week 4 post-baseline during therapy session
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Positive and Negative Affect Schedule
時間枠：Week 5 post-baseline during therapy session
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The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
Week 5 post-baseline during therapy session
|
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Positive and Negative Affect Schedule
時間枠：1 week after the last therapy session, at week 6 post-baseline
|
The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
1 week after the last therapy session, at week 6 post-baseline
|
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Positive and Negative Affect Schedule
時間枠：3-months posttreatment completion, at week 18 post-baseline
|
The 20-item Positive and Negative Affect Schedule (PANAS) examined past-week positive and negative affect levels. There were 10 items for each of the PANAS-Positive and PANAS-Negative subscales, which measure past-week positive and negative affect respectively. Response options ranged from 1 (not at all/very slightly) to 5 (extremely), with the possible range being from 10 to 50 for each subscale. Higher scores mean more self-reported positive affect and negative affect for the PANAS-Positive and PANAS-Negative subscales respectively. |
3-months posttreatment completion, at week 18 post-baseline
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協力者と研究者
捜査官
- 主任研究者：Ateka Contractor, PHD、University of North Texas Health Science Center
出版物と役立つリンク
一般刊行物
- Contractor AA, Blumenthal H, Rosenfield D, Shea MT, Taylor DJ, Fentem A, Vingren JL. Study protocol and rationale for a pilot randomized clinical trial comparing processing of positive memories technique with supportive counseling for PTSD. Contemp Clin Trials. 2024 Mar;138:107455. doi: 10.1016/j.cct.2024.107455. Epub 2024 Jan 20.
- Rodenbaugh MM, Almeida I, Solakoglu L, Jin L, Contractor AA. Client and therapist experiences with the Processing of Positive Memories Technique (PPMT) in a randomized controlled trial: insights for protocol refinement. Eur J Psychotraumatol. 2026 Dec;17(1):2692887. doi: 10.1080/20008066.2026.2692887. Epub 2026 Jul 29.
- Contractor AA, Rosenfield D, Almeida IM, Wang S, Taylor DJ, Weiss NH, Shea MT. Comparison of the processing of positive memories technique and supportive counseling for posttraumatic stress disorder: A randomized controlled trial. Behav Res Ther. 2026 Aug;203:105087. doi: 10.1016/j.brat.2026.105087. Epub 2026 May 19.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- R15MH129773-01A1 (米国 NIH グラント/契約)
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
米国で製造され、米国から輸出された製品。
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