Mental Rotation and Motor Imagery Training in Multiple Sclerosis
2026年8月5日 更新者：Ramazan KURUL、Abant Izzet Baysal University
Mental Rotation and Motor Imagery Training for Upper-Extremity Function in Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of sequential laterality, motor imagery, and mental rotation training in individuals with relapsing-remitting multiple sclerosis.
Both groups received conventional physiotherapy, while the intervention group received structured cognitive-motor training and the control group received active visual-attention training.
調査の概要
状態
完了
詳細な説明
Fifty-four participants were randomly assigned to the intervention or control group.
Both groups received 45-minute sessions three times per week for six weeks.
Mental rotation ability was the primary outcome, while upper-extremity function, manual ability, motor imagery, grip strength, dexterity, and information-processing speed were assessed as secondary outcomes.
Assessments were performed before and after the intervention by a researcher blinded to group allocation.
研究の種類
介入
入学 (実際)
54
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Bolu、トルコ（Türkiye）、14100
- Abant Izzet Baysal University Faculty of Health Science
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
いいえ
説明
Inclusion Criteria:
- Diagnosed with definite relapsing-remitting multiple sclerosis by a neurologist according to the revised McDonald criteria
- Not experiencing an acute MS relapse
- Mini Mental State Examination score ≥24
- No clinical MS relapse within the previous 3 months
- No corticosteroid treatment for an MS relapse within the previous 3 months
- Expanded Disability Status Scale score between 1.5 and 6.0
- Modified Ashworth Scale score ≤2
- Sufficient communication ability to understand visual and verbal instructions and follow the training protocol
- Able to attend at least 80% of the planned sessions
- Able to complete the Movement Imagery Questionnaire-3
Exclusion Criteria:
- Any medication change within the previous 3 months
- Uncorrected severe visual or hearing impairment
- A communication disorder preventing the perception of or response to the visual and verbal stimuli used in the study
- Participation in another structured upper-extremity rehabilitation program or interventional study during the study period
- Presence of an additional neurological disorder
- Advanced sensory loss or proprioceptive impairment that could affect participation in the intervention
- Botulinum toxin injection within the previous 3 months
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Multicomponent rotation training
Participants received 30 minutes of conventional physiotherapy and 15 minutes of sequential laterality, motor imagery, and mental rotation training, three times per week for six weeks.
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Participants received 30 minutes of conventional physiotherapy followed by 15 minutes of structured training, three times per week for six weeks.
The training progressed sequentially through laterality recognition, motor imagery, and mental rotation.
Laterality training involved identifying right- and left-hand images.
Motor imagery training involved imagining the hand positions and movements shown in the images without performing an observable movement.
Mental rotation training involved mentally rotating figures and selecting the correct response.
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偽コンパレータ：Sham training
Participants received 30 minutes of conventional physiotherapy and 15 minutes of active visual-attention training using neutral objects, colors, shapes, and symbols, three times per week for six weeks.
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Participants received 30 minutes of conventional physiotherapy followed by 15 minutes of active visual-attention control training, three times per week for six weeks.
The training included images of neutral objects, colors, geometric shapes, and symbols that did not depict body parts.
Participants classified the images according to color, shape, size, position, or similarity and difference.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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The Purdue Spatial Visualization Test
時間枠：Baseline and immediately after the 6-week intervention.
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The Purdue Spatial Visualization Test a widely used mental rotation tests, consists of 30 three-dimensional spatial perception questions.
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Baseline and immediately after the 6-week intervention.
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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The Symbol Digit Modalities Test
時間枠：Baseline and immediately after the 6-week intervention.
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The Symbol Digit Modalities Test is a widely used assessment tool for measuring information-processing speed in patients with MS.
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Baseline and immediately after the 6-week intervention.
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Nine-Hole Peg Test
時間枠：Baseline and immediately after the 6-week intervention.
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In the Nine-Hole Peg Test, nine wooden pegs were placed into a wooden board containing nine holes using one hand.
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Baseline and immediately after the 6-week intervention.
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Kinesthetic and Visual Imagery Questionnaire
時間枠：Baseline and immediately after the 6-week intervention.
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Motor imagery ability was evaluated and scored using 20 items examining movements of different body parts in a sitting position, with two subscales assessing kinesthetic and visual imagery abilities.
The total score ranges from 10 to 50, with each subscale ranging from 5 to 25.
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Baseline and immediately after the 6-week intervention.
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Grip Strength
時間枠：Baseline and immediately after the 6-week intervention
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Grip strength was assessed using a Jamar hand dynamometer.
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Baseline and immediately after the 6-week intervention
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Abilhand
時間枠：Baseline and immediately after the 6-week intervention.
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Abilhand is a patient-reported scale used to determine the perceived level of difficulty individuals experience when using their hands during activities of daily living.
The Abilhand total raw score ranges from 0 to 46, with higher scores indicating better self-perceived manual ability in performing daily bimanual activities.
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Baseline and immediately after the 6-week intervention.
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The Action Research Arm Test (ARAT)
時間枠：Baseline and immediately after the 6-week intervention.
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The Action Research Arm Test was used to evaluate upper extremity functional capacity and consists of four subdomains: grasp, grip, pinch, and gross movement.
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Baseline and immediately after the 6-week intervention.
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- 主任研究者：Enes Tayyip Benli, phd、Abant Izzet Baysal University
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2024年2月15日
一次修了 (実際)
2026年1月15日
研究の完了 (実際)
2026年2月15日
試験登録日
最初に提出
2026年7月30日
QC基準を満たした最初の提出物
2026年8月5日
最初の投稿 (実際)
2026年8月6日
学習記録の更新
投稿された最後の更新 (実際)
2026年8月6日
QC基準を満たした最後の更新が送信されました
2026年8月5日
最終確認日
2026年8月1日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- AIBU-FTR-BENLI-010
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
いいえ
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
いいえ
米国FDA規制機器製品の研究
いいえ
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